Circulatory resistin levels in inflammatory bowel disease: a systematic review and meta-analysis
Abstract Background Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic relapsing-remitting systemic disease of the gastrointestinal tract with rising incidence. Studies have shown that adipocytes play a crucial role in patients with IBD by acti...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-024-03199-7 |
| _version_ | 1797259248225222656 |
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| author | Amir Hossein Behnoush Seyede Parmis Maroufi Tara Reshadmanesh Yasmin Mohtasham Kia Mitra Norouzi Seyedeh Mina Mohammadi Aleksandra Klisic Amirmohammad Khalaji |
| author_facet | Amir Hossein Behnoush Seyede Parmis Maroufi Tara Reshadmanesh Yasmin Mohtasham Kia Mitra Norouzi Seyedeh Mina Mohammadi Aleksandra Klisic Amirmohammad Khalaji |
| author_sort | Amir Hossein Behnoush |
| collection | DOAJ |
| description | Abstract Background Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic relapsing-remitting systemic disease of the gastrointestinal tract with rising incidence. Studies have shown that adipocytes play a crucial role in patients with IBD by actively participating in systemic immune responses. The present study was designed to investigate the correlation between the circulatory levels of resistin, as an adipokine, and active and remission phases of IBD in comparison with healthy controls. Methods Relevant articles were retrieved from PubMed, Embase, the Web of Science, and Scopus from inception until June 2023. Estimation of the standardized mean difference (SMD) and 95% confidence interval (CI) for comparison of plasma/serum resistin levels between IBD patients, patients in remission, and healthy controls were conducted through random-effect meta-analysis. Results A total of 19 studies were included, assessing 1836 cases. Meta-analysis indicated that generally, serum/plasma resistin levels were higher in IBD patients in comparison with healthy controls (SMD 1.33, 95% CI 0.58 to 2.08, p-value < 0.01). This was true for each of the UC and CD separate analyses, as well. Moreover, it was shown that higher serum/plasma resistin levels were detected in the active phase of IBD than in the remission phase (SMD 1.04, 95% CI 0.65 to 1.42, p-value = 0.01). Finally, higher serum/plasma resistin levels were found in the remission phase compared to healthy controls (SMD 0.60, 95% CI 0.15 to 1.06, p-value < 0.01). Conclusion The results of this systematic review and meta-analysis support the conclusion that circulating resistin levels are increased in IBD (both UC and CD). Also, higher resistin levels were recorded in the remission phase of IBD in comparison with healthy controls. This indicates that further studies may provide valuable insights into the role of resistin in the pathogenesis of IBD. |
| first_indexed | 2024-04-24T23:06:24Z |
| format | Article |
| id | doaj.art-d21954fe5fa34b13b67b2fa65a294320 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-04-24T23:06:24Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-d21954fe5fa34b13b67b2fa65a2943202024-03-17T12:28:00ZengBMCBMC Gastroenterology1471-230X2024-03-0124111310.1186/s12876-024-03199-7Circulatory resistin levels in inflammatory bowel disease: a systematic review and meta-analysisAmir Hossein Behnoush0Seyede Parmis Maroufi1Tara Reshadmanesh2Yasmin Mohtasham Kia3Mitra Norouzi4Seyedeh Mina Mohammadi5Aleksandra Klisic6Amirmohammad Khalaji7School of Medicine, Tehran University of Medical SciencesNeurosurgical Research Network, Universal Scientific Education and Research Network, Tehran University of Medical SciencesStudent Research Center, School of Medicine, Zanjan University of Medical ScienceSchool of Medicine, Iran University of Medical SciencesFaculty of Life Sciences and Biotechnology, Shahid Beheshti UniversityIslamic Azad University Tehran Faculty of MedicineFaculty of Medicine, University of MontenegroSchool of Medicine, Tehran University of Medical SciencesAbstract Background Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic relapsing-remitting systemic disease of the gastrointestinal tract with rising incidence. Studies have shown that adipocytes play a crucial role in patients with IBD by actively participating in systemic immune responses. The present study was designed to investigate the correlation between the circulatory levels of resistin, as an adipokine, and active and remission phases of IBD in comparison with healthy controls. Methods Relevant articles were retrieved from PubMed, Embase, the Web of Science, and Scopus from inception until June 2023. Estimation of the standardized mean difference (SMD) and 95% confidence interval (CI) for comparison of plasma/serum resistin levels between IBD patients, patients in remission, and healthy controls were conducted through random-effect meta-analysis. Results A total of 19 studies were included, assessing 1836 cases. Meta-analysis indicated that generally, serum/plasma resistin levels were higher in IBD patients in comparison with healthy controls (SMD 1.33, 95% CI 0.58 to 2.08, p-value < 0.01). This was true for each of the UC and CD separate analyses, as well. Moreover, it was shown that higher serum/plasma resistin levels were detected in the active phase of IBD than in the remission phase (SMD 1.04, 95% CI 0.65 to 1.42, p-value = 0.01). Finally, higher serum/plasma resistin levels were found in the remission phase compared to healthy controls (SMD 0.60, 95% CI 0.15 to 1.06, p-value < 0.01). Conclusion The results of this systematic review and meta-analysis support the conclusion that circulating resistin levels are increased in IBD (both UC and CD). Also, higher resistin levels were recorded in the remission phase of IBD in comparison with healthy controls. This indicates that further studies may provide valuable insights into the role of resistin in the pathogenesis of IBD.https://doi.org/10.1186/s12876-024-03199-7Inflammatory Bowel DiseaseUlcerative ColitisCrohnResistinSystematic ReviewMeta-analysis |
| spellingShingle | Amir Hossein Behnoush Seyede Parmis Maroufi Tara Reshadmanesh Yasmin Mohtasham Kia Mitra Norouzi Seyedeh Mina Mohammadi Aleksandra Klisic Amirmohammad Khalaji Circulatory resistin levels in inflammatory bowel disease: a systematic review and meta-analysis BMC Gastroenterology Inflammatory Bowel Disease Ulcerative Colitis Crohn Resistin Systematic Review Meta-analysis |
| title | Circulatory resistin levels in inflammatory bowel disease: a systematic review and meta-analysis |
| title_full | Circulatory resistin levels in inflammatory bowel disease: a systematic review and meta-analysis |
| title_fullStr | Circulatory resistin levels in inflammatory bowel disease: a systematic review and meta-analysis |
| title_full_unstemmed | Circulatory resistin levels in inflammatory bowel disease: a systematic review and meta-analysis |
| title_short | Circulatory resistin levels in inflammatory bowel disease: a systematic review and meta-analysis |
| title_sort | circulatory resistin levels in inflammatory bowel disease a systematic review and meta analysis |
| topic | Inflammatory Bowel Disease Ulcerative Colitis Crohn Resistin Systematic Review Meta-analysis |
| url | https://doi.org/10.1186/s12876-024-03199-7 |
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