Opinion Polls and Antibody Response Dynamics of Vaccination with COVID-19 Booster Vaccines
As the third year of the global COVID-19 pandemic, vaccination remains the most effective tool against infections and symptomatic illness. Comprehension regarding immunity to SARS-CoV-2 is limited, and the durability of immune responses after vaccination is currently not clear. In this study, we ran...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/5/647 |
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| author | Yufei Wu Huanjie Li Yangyang Wang Ping Huang Yihui Xu Mingjie Xu Qianqian Zhao Yunying Zhou Jun Wang Mingyu Ji Yunshan Wang |
| author_facet | Yufei Wu Huanjie Li Yangyang Wang Ping Huang Yihui Xu Mingjie Xu Qianqian Zhao Yunying Zhou Jun Wang Mingyu Ji Yunshan Wang |
| author_sort | Yufei Wu |
| collection | DOAJ |
| description | As the third year of the global COVID-19 pandemic, vaccination remains the most effective tool against infections and symptomatic illness. Comprehension regarding immunity to SARS-CoV-2 is limited, and the durability of immune responses after vaccination is currently not clear. In this study, we randomly collected 395 questionnaires to analyze the current state of COVID-19 vaccination. At the same time, the serum of 16 individuals who had received two doses of the COVID-19 vaccine were collected at different times before and after the booster vaccination. We analyzed the dynamic changes of SARS-CoV-2 S-specific binding antibodies in serum and immunological indicators. By collecting public opinion surveys and analyzing variational trends of SARS-CoV-2 S-specific binding antibodies and immune indicators after COVID-19 booster vaccination, we endeavored to demonstrate the concerns affecting people’s booster vaccinations, as well as the frequency, timing, and necessity of COVID-19 booster vaccinations. The analysis of antibody results in 16 vaccinated volunteers showed that the antibody concentration decreased six months after the second dose and the protective effect of the virus was reduced. The third dose of COVID-19 vaccination is necessary to maintain the antibody concentration and the protective effect of the virus. The vaccination with the vaccine booster depends not only on the time interval but also on the initial concentration of the SARS-CoV-2 S-specific binding antibody before the booster. Our study has important implications for raising public awareness of vaccinating against SARS-CoV-2 and the necessity of COVID-19 booster vaccinations. |
| first_indexed | 2024-03-10T01:40:46Z |
| format | Article |
| id | doaj.art-d21a00ba0a4b4dbb982f865ef1983046 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T01:40:46Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-d21a00ba0a4b4dbb982f865ef19830462023-11-23T13:24:51ZengMDPI AGVaccines2076-393X2022-04-0110564710.3390/vaccines10050647Opinion Polls and Antibody Response Dynamics of Vaccination with COVID-19 Booster VaccinesYufei Wu0Huanjie Li1Yangyang Wang2Ping Huang3Yihui Xu4Mingjie Xu5Qianqian Zhao6Yunying Zhou7Jun Wang8Mingyu Ji9Yunshan Wang10School of Medicine, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan 250012, ChinaSchool of Medicine, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan 250012, ChinaSchool of Medicine, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan 250012, ChinaMedical Research and Laboratory Diagnostic Center, Jinan Central Hospital Affiliated Shandong First Medical University, 105 Jiefang Road, Jinan 250013, ChinaMedical Research and Laboratory Diagnostic Center, Jinan Central Hospital Affiliated Shandong First Medical University, 105 Jiefang Road, Jinan 250013, ChinaMedical Research and Laboratory Diagnostic Center, Jinan Central Hospital Affiliated Shandong First Medical University, 105 Jiefang Road, Jinan 250013, ChinaMedical Research and Laboratory Diagnostic Center, Jinan Central Hospital Affiliated Shandong First Medical University, 105 Jiefang Road, Jinan 250013, ChinaMedical Research and Laboratory Diagnostic Center, Jinan Central Hospital Affiliated Shandong First Medical University, 105 Jiefang Road, Jinan 250013, ChinaMedical Research and Laboratory Diagnostic Center, Jinan Central Hospital Affiliated Shandong First Medical University, 105 Jiefang Road, Jinan 250013, ChinaSchool of Medicine, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan 250012, ChinaSchool of Medicine, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan 250012, ChinaAs the third year of the global COVID-19 pandemic, vaccination remains the most effective tool against infections and symptomatic illness. Comprehension regarding immunity to SARS-CoV-2 is limited, and the durability of immune responses after vaccination is currently not clear. In this study, we randomly collected 395 questionnaires to analyze the current state of COVID-19 vaccination. At the same time, the serum of 16 individuals who had received two doses of the COVID-19 vaccine were collected at different times before and after the booster vaccination. We analyzed the dynamic changes of SARS-CoV-2 S-specific binding antibodies in serum and immunological indicators. By collecting public opinion surveys and analyzing variational trends of SARS-CoV-2 S-specific binding antibodies and immune indicators after COVID-19 booster vaccination, we endeavored to demonstrate the concerns affecting people’s booster vaccinations, as well as the frequency, timing, and necessity of COVID-19 booster vaccinations. The analysis of antibody results in 16 vaccinated volunteers showed that the antibody concentration decreased six months after the second dose and the protective effect of the virus was reduced. The third dose of COVID-19 vaccination is necessary to maintain the antibody concentration and the protective effect of the virus. The vaccination with the vaccine booster depends not only on the time interval but also on the initial concentration of the SARS-CoV-2 S-specific binding antibody before the booster. Our study has important implications for raising public awareness of vaccinating against SARS-CoV-2 and the necessity of COVID-19 booster vaccinations.https://www.mdpi.com/2076-393X/10/5/647COVID-19SARS-CoV-2booster vaccinesantibody response dynamics |
| spellingShingle | Yufei Wu Huanjie Li Yangyang Wang Ping Huang Yihui Xu Mingjie Xu Qianqian Zhao Yunying Zhou Jun Wang Mingyu Ji Yunshan Wang Opinion Polls and Antibody Response Dynamics of Vaccination with COVID-19 Booster Vaccines Vaccines COVID-19 SARS-CoV-2 booster vaccines antibody response dynamics |
| title | Opinion Polls and Antibody Response Dynamics of Vaccination with COVID-19 Booster Vaccines |
| title_full | Opinion Polls and Antibody Response Dynamics of Vaccination with COVID-19 Booster Vaccines |
| title_fullStr | Opinion Polls and Antibody Response Dynamics of Vaccination with COVID-19 Booster Vaccines |
| title_full_unstemmed | Opinion Polls and Antibody Response Dynamics of Vaccination with COVID-19 Booster Vaccines |
| title_short | Opinion Polls and Antibody Response Dynamics of Vaccination with COVID-19 Booster Vaccines |
| title_sort | opinion polls and antibody response dynamics of vaccination with covid 19 booster vaccines |
| topic | COVID-19 SARS-CoV-2 booster vaccines antibody response dynamics |
| url | https://www.mdpi.com/2076-393X/10/5/647 |
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