Lactoferrin and Nanotechnology: The Potential for Cancer Treatment
Lactoferrin (Lf)—a glycoprotein of the transferrin family—has been investigated as a promising molecule with diverse applications, including infection inhibition, anti-inflammation, antioxidant properties and immune modulation. Along with that, Lf was found to inhibit the growth of cancerous tumors....
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/5/1362 |
| _version_ | 1827740426269884416 |
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| author | Tuan Hiep Tran Phuong Thi Thu Tran Duy Hieu Truong |
| author_facet | Tuan Hiep Tran Phuong Thi Thu Tran Duy Hieu Truong |
| author_sort | Tuan Hiep Tran |
| collection | DOAJ |
| description | Lactoferrin (Lf)—a glycoprotein of the transferrin family—has been investigated as a promising molecule with diverse applications, including infection inhibition, anti-inflammation, antioxidant properties and immune modulation. Along with that, Lf was found to inhibit the growth of cancerous tumors. Owing to unique properties such as iron-binding and positive charge, Lf could interrupt the cancer cell membrane or influence the apoptosis pathway. In addition, being a common mammalian excretion, Lf offers is promising in terms of targeting delivery or the diagnosis of cancer. Recently, nanotechnology significantly enhanced the therapeutic index of natural glycoproteins such as Lf. Therefore, in the context of this review, the understanding of Lf is summarized and followed by different strategies of nano-preparation, including inorganic nanoparticles, lipid-based nanoparticles and polymer-based nanoparticles in cancer management. At the end of the study, the potential future applications are discussed to pave the way for translating Lf into actual usage. |
| first_indexed | 2024-03-11T03:24:46Z |
| format | Article |
| id | doaj.art-d21a6901f5084d58b66dd1b6d4bf6e8b |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T03:24:46Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-d21a6901f5084d58b66dd1b6d4bf6e8b2023-11-18T02:50:30ZengMDPI AGPharmaceutics1999-49232023-04-01155136210.3390/pharmaceutics15051362Lactoferrin and Nanotechnology: The Potential for Cancer TreatmentTuan Hiep Tran0Phuong Thi Thu Tran1Duy Hieu Truong2Faculty of Pharmacy, Phenikaa University, Yen Nghia, Ha Dong, Hanoi 12116, VietnamDepartment of Life Sciences, University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 10000, VietnamBac Ly Ward, Dong Hoi City 510000, VietnamLactoferrin (Lf)—a glycoprotein of the transferrin family—has been investigated as a promising molecule with diverse applications, including infection inhibition, anti-inflammation, antioxidant properties and immune modulation. Along with that, Lf was found to inhibit the growth of cancerous tumors. Owing to unique properties such as iron-binding and positive charge, Lf could interrupt the cancer cell membrane or influence the apoptosis pathway. In addition, being a common mammalian excretion, Lf offers is promising in terms of targeting delivery or the diagnosis of cancer. Recently, nanotechnology significantly enhanced the therapeutic index of natural glycoproteins such as Lf. Therefore, in the context of this review, the understanding of Lf is summarized and followed by different strategies of nano-preparation, including inorganic nanoparticles, lipid-based nanoparticles and polymer-based nanoparticles in cancer management. At the end of the study, the potential future applications are discussed to pave the way for translating Lf into actual usage.https://www.mdpi.com/1999-4923/15/5/1362lactoferrinnanoparticlescancertargetingtherapy |
| spellingShingle | Tuan Hiep Tran Phuong Thi Thu Tran Duy Hieu Truong Lactoferrin and Nanotechnology: The Potential for Cancer Treatment Pharmaceutics lactoferrin nanoparticles cancer targeting therapy |
| title | Lactoferrin and Nanotechnology: The Potential for Cancer Treatment |
| title_full | Lactoferrin and Nanotechnology: The Potential for Cancer Treatment |
| title_fullStr | Lactoferrin and Nanotechnology: The Potential for Cancer Treatment |
| title_full_unstemmed | Lactoferrin and Nanotechnology: The Potential for Cancer Treatment |
| title_short | Lactoferrin and Nanotechnology: The Potential for Cancer Treatment |
| title_sort | lactoferrin and nanotechnology the potential for cancer treatment |
| topic | lactoferrin nanoparticles cancer targeting therapy |
| url | https://www.mdpi.com/1999-4923/15/5/1362 |
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