Morphological analysis of ventricular septal defect by echocardiography for prediction of aortic regurgitation in pediatric population
Abstract Ventricular septal defects (VSD) are the most common congenital heart diseases in children. Among them, perimembranous VSD (pm-VSD) have a higher risk of complications, including aortic valve prolapse and aortic regurgitation (AR). The aim of our study was to assess echocardiographic criter...
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| Format: | Article |
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Nature Portfolio
2023-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-32940-7 |
| _version_ | 1797836442999717888 |
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| author | Fedoua El Louali Floriane Soler Virginie Fouilloux Morgane Evin Caroline Ovaert |
| author_facet | Fedoua El Louali Floriane Soler Virginie Fouilloux Morgane Evin Caroline Ovaert |
| author_sort | Fedoua El Louali |
| collection | DOAJ |
| description | Abstract Ventricular septal defects (VSD) are the most common congenital heart diseases in children. Among them, perimembranous VSD (pm-VSD) have a higher risk of complications, including aortic valve prolapse and aortic regurgitation (AR). The aim of our study was to assess echocardiographic criteria associated with AR during follow-up of pm-VSD. Forty children with restrictive pm-VSD, followed-up in our unit and who underwent a workable echocardiographic evaluation between 2015 and 2019 were included and retrospectively analyzed. The propensity score was used to match 15 patients with AR to 15 patients without AR. Median age was 2.2 year [1.4–5.7]. Median weight was 14 kg [9.9–20.3]. Aortic annulus z-score, Valsalva sinus z-score, sinotubular junction z-score, valve prolapse and commissure commitment were significantly different between the two groups (p = 0.047, p = 0.001, p = 0.010, p = 0.007, p < 0.001 respectively). Aortic root dilatation, aortic valve prolapse and commissure commitment to a perimembranous VSD are associated to aortic regurgitation. |
| first_indexed | 2024-04-09T15:10:06Z |
| format | Article |
| id | doaj.art-d21adbb3a799479baeb6529749e2f0dc |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T15:10:06Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d21adbb3a799479baeb6529749e2f0dc2023-04-30T11:17:19ZengNature PortfolioScientific Reports2045-23222023-04-011311710.1038/s41598-023-32940-7Morphological analysis of ventricular septal defect by echocardiography for prediction of aortic regurgitation in pediatric populationFedoua El Louali0Floriane Soler1Virginie Fouilloux2Morgane Evin3Caroline Ovaert4Pediatric and Congenital Cardiology Department, La Timone Hospital, Assistance Publique – Hôpitaux de MarseillePediatric and Congenital Cardiology Department, La Timone Hospital, Assistance Publique – Hôpitaux de MarseillePediatric and Congenital Cardiology Department, La Timone Hospital, Assistance Publique – Hôpitaux de MarseilleLaboratory of Biomechanics and Application, UMRT24, Gustave Eiffel University, Aix Marseille UniversityPediatric and Congenital Cardiology Department, La Timone Hospital, Assistance Publique – Hôpitaux de MarseilleAbstract Ventricular septal defects (VSD) are the most common congenital heart diseases in children. Among them, perimembranous VSD (pm-VSD) have a higher risk of complications, including aortic valve prolapse and aortic regurgitation (AR). The aim of our study was to assess echocardiographic criteria associated with AR during follow-up of pm-VSD. Forty children with restrictive pm-VSD, followed-up in our unit and who underwent a workable echocardiographic evaluation between 2015 and 2019 were included and retrospectively analyzed. The propensity score was used to match 15 patients with AR to 15 patients without AR. Median age was 2.2 year [1.4–5.7]. Median weight was 14 kg [9.9–20.3]. Aortic annulus z-score, Valsalva sinus z-score, sinotubular junction z-score, valve prolapse and commissure commitment were significantly different between the two groups (p = 0.047, p = 0.001, p = 0.010, p = 0.007, p < 0.001 respectively). Aortic root dilatation, aortic valve prolapse and commissure commitment to a perimembranous VSD are associated to aortic regurgitation.https://doi.org/10.1038/s41598-023-32940-7 |
| spellingShingle | Fedoua El Louali Floriane Soler Virginie Fouilloux Morgane Evin Caroline Ovaert Morphological analysis of ventricular septal defect by echocardiography for prediction of aortic regurgitation in pediatric population Scientific Reports |
| title | Morphological analysis of ventricular septal defect by echocardiography for prediction of aortic regurgitation in pediatric population |
| title_full | Morphological analysis of ventricular septal defect by echocardiography for prediction of aortic regurgitation in pediatric population |
| title_fullStr | Morphological analysis of ventricular septal defect by echocardiography for prediction of aortic regurgitation in pediatric population |
| title_full_unstemmed | Morphological analysis of ventricular septal defect by echocardiography for prediction of aortic regurgitation in pediatric population |
| title_short | Morphological analysis of ventricular septal defect by echocardiography for prediction of aortic regurgitation in pediatric population |
| title_sort | morphological analysis of ventricular septal defect by echocardiography for prediction of aortic regurgitation in pediatric population |
| url | https://doi.org/10.1038/s41598-023-32940-7 |
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