Biodistribution and dosimetry of the GluN2B-specific NMDA receptor PET radioligand (R)-[11C]Me-NB1

Biodistribution and dosimetry of the GluN2B-specific NMDA receptor PET radioligand (R)-[11C]Me-NB1

Abstract Background The NMDA receptor (NMDAR) plays a key role in the central nervous system, e.g., for synaptic transmission. While synaptic NMDARs are thought to have protective characteristics, activation of extrasynaptic NMDARs might trigger excitotoxic processes linked to neuropsychiatric disor...

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Podrobná bibliografie
Hlavní autoři: Lucas Rischka, Matej Murgaš, Verena Pichler, Chrysoula Vraka, Ivo Rausch, Dietmar Winkler, Lukas Nics, Sazan Rasul, Leo Robert Silberbauer, Murray Bruce Reed, Godber Mathis Godbersen, Jakob Unterholzner, Patricia Handschuh, Gregor Gryglewski, Thomas Mindt, Markus Mitterhauser, Andreas Hahn, Simon Mensah Ametamey, Wolfgang Wadsak, Rupert Lanzenberger, Marcus Hacker
Médium: Článek
Jazyk:English
Vydáno: SpringerOpen 2022-08-01
Edice:EJNMMI Research
Témata:
GluN2B-subunit
NMDA receptor
PET
Dosimetry
Biodistribution
Neuropsychiatric disorders
On-line přístup:https://doi.org/10.1186/s13550-022-00925-8

Internet

https://doi.org/10.1186/s13550-022-00925-8

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