Targeting Cartilage Degradation in Osteoarthritis
Osteoarthritis is a common, degenerative joint disease with significant socio-economic impact worldwide. There are currently no disease-modifying drugs available to treat the disease, making this an important area of pharmaceutical research. In this review, we assessed approaches being explored to d...
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| Natura: | Articolo |
| Lingua: | English |
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MDPI AG
2021-02-01
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| Serie: | Pharmaceuticals |
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| Accesso online: | https://www.mdpi.com/1424-8247/14/2/126 |
| _version_ | 1827602942197235712 |
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| author | Oliver McClurg Ryan Tinson Linda Troeberg |
| author_facet | Oliver McClurg Ryan Tinson Linda Troeberg |
| author_sort | Oliver McClurg |
| collection | DOAJ |
| description | Osteoarthritis is a common, degenerative joint disease with significant socio-economic impact worldwide. There are currently no disease-modifying drugs available to treat the disease, making this an important area of pharmaceutical research. In this review, we assessed approaches being explored to directly inhibit metalloproteinase-mediated cartilage degradation and to counteract cartilage damage by promoting growth factor-driven repair. Metalloproteinase-blocking antibodies are discussed, along with recent clinical trials on FGF18 and Wnt pathway inhibitors. We also considered dendrimer-based approaches being developed to deliver and retain such therapeutics in the joint environment. These may reduce systemic side effects while improving local half-life and concentration. Development of such targeted anabolic therapies would be of great benefit in the osteoarthritis field. |
| first_indexed | 2024-03-09T05:28:42Z |
| format | Article |
| id | doaj.art-d21d3d0fa34445a1b62ff1829c253e07 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T05:28:42Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-d21d3d0fa34445a1b62ff1829c253e072023-12-03T12:34:58ZengMDPI AGPharmaceuticals1424-82472021-02-0114212610.3390/ph14020126Targeting Cartilage Degradation in OsteoarthritisOliver McClurg0Ryan Tinson1Linda Troeberg2Norwich Medical School, University of East Anglia, Bob Champion Research and Education Building, Rosalind Franklin Road, Norwich NR4 7UQ, UKNorwich Medical School, University of East Anglia, Bob Champion Research and Education Building, Rosalind Franklin Road, Norwich NR4 7UQ, UKNorwich Medical School, University of East Anglia, Bob Champion Research and Education Building, Rosalind Franklin Road, Norwich NR4 7UQ, UKOsteoarthritis is a common, degenerative joint disease with significant socio-economic impact worldwide. There are currently no disease-modifying drugs available to treat the disease, making this an important area of pharmaceutical research. In this review, we assessed approaches being explored to directly inhibit metalloproteinase-mediated cartilage degradation and to counteract cartilage damage by promoting growth factor-driven repair. Metalloproteinase-blocking antibodies are discussed, along with recent clinical trials on FGF18 and Wnt pathway inhibitors. We also considered dendrimer-based approaches being developed to deliver and retain such therapeutics in the joint environment. These may reduce systemic side effects while improving local half-life and concentration. Development of such targeted anabolic therapies would be of great benefit in the osteoarthritis field.https://www.mdpi.com/1424-8247/14/2/126osteoarthritiscartilagemetalloproteinasetargeting |
| spellingShingle | Oliver McClurg Ryan Tinson Linda Troeberg Targeting Cartilage Degradation in Osteoarthritis Pharmaceuticals osteoarthritis cartilage metalloproteinase targeting |
| title | Targeting Cartilage Degradation in Osteoarthritis |
| title_full | Targeting Cartilage Degradation in Osteoarthritis |
| title_fullStr | Targeting Cartilage Degradation in Osteoarthritis |
| title_full_unstemmed | Targeting Cartilage Degradation in Osteoarthritis |
| title_short | Targeting Cartilage Degradation in Osteoarthritis |
| title_sort | targeting cartilage degradation in osteoarthritis |
| topic | osteoarthritis cartilage metalloproteinase targeting |
| url | https://www.mdpi.com/1424-8247/14/2/126 |
| work_keys_str_mv | AT olivermcclurg targetingcartilagedegradationinosteoarthritis AT ryantinson targetingcartilagedegradationinosteoarthritis AT lindatroeberg targetingcartilagedegradationinosteoarthritis |