Long-term channelrhodopsin-2 (ChR2) expression can induce abnormal axonal morphology and targeting in cerebral cortex

Long-term channelrhodopsin-2 (ChR2) expression can induce abnormal axonal morphology and targeting in cerebral cortex

Long-term expression of optogenetic proteins including channelrhodopsin-2 (ChR2) is widely used to study neural circuit function, but whether ChR2 expression itself perturbs circuits is not known. We expressed a common construct, CAG::ChR2(H134R)-EYFP-WPRE, in L2/3 pyramidal cells in rat somatosens...

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Bibliographic Details
Main Authors: Toshio eMiyashita, Yu R Shao, Jason eChung, Olivia ePourzia, Dan eFeldman
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-01-01
Series:Frontiers in Neural Circuits
Subjects:
optogenetics
circuit
in utero electroporation
axon development
axonal malformation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00008/full

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