Cytokine Pathways and Investigational Target Therapies in Hidradenitis Suppurativa
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease affecting areas with a high density of apocrine glands and characterized by subcutaneous nodules that may evolve into fistulas with pus secretion. Methods: The aim of this review is to investigate all current knowledge...
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| Format: | Article |
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MDPI AG
2020-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/22/8436 |
| _version_ | 1797548361623011328 |
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| author | Ester Del Duca Paola Morelli Luigi Bennardo Cosimo Di Raimondo Steven Paul Nisticò |
| author_facet | Ester Del Duca Paola Morelli Luigi Bennardo Cosimo Di Raimondo Steven Paul Nisticò |
| author_sort | Ester Del Duca |
| collection | DOAJ |
| description | Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease affecting areas with a high density of apocrine glands and characterized by subcutaneous nodules that may evolve into fistulas with pus secretion. Methods: The aim of this review is to investigate all current knowledge on cytokine regulation in the pathogenesis of HS. A systematic literature research using the words “cytokine”, “interleukin”, “pathway”, and “hidradenitis suppurativa” was performed in PubMed/Medline and Scopus/Embase databases. A search of the clinicaltrials.gov website for interventional recruiting and completed trials including the term “hidradenitis suppurativa” was also performed up to August 2020. We will discuss the pathogenetic role of various cytokines in HS and potential therapeutic targets for this debilitating disease. Results: The pathophysiology underlying this complex condition has not been clearly defined. An upregulation of various cytokines, such as tumor necrosis factor alpha (TNF-α), interleukin (IL)-1, IL-17, IL-23, and other molecules seems to be related to this inflammatory condition. Various cells, such as lymphocytes T Helper 1 and 17 and keratinocytes seem to be involved in the genesis of this condition. Conclusions: Several future studies and clinical trials are necessary in order to have new knowledge about HS and to properly treat this complex condition. |
| first_indexed | 2024-03-10T14:58:17Z |
| format | Article |
| id | doaj.art-d21e19588bc5457da4521b735a368319 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:58:17Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d21e19588bc5457da4521b735a3683192023-11-20T20:26:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-012122843610.3390/ijms21228436Cytokine Pathways and Investigational Target Therapies in Hidradenitis SuppurativaEster Del Duca0Paola Morelli1Luigi Bennardo2Cosimo Di Raimondo3Steven Paul Nisticò4Department of Health Science, University of Catanzaro Magna Graecia, 88100 Catanzaro, ItalyDepartment of Health Science, University of Catanzaro Magna Graecia, 88100 Catanzaro, ItalyDepartment of Health Science, University of Catanzaro Magna Graecia, 88100 Catanzaro, ItalyDepartment of Dermatology, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Health Science, University of Catanzaro Magna Graecia, 88100 Catanzaro, ItalyBackground: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease affecting areas with a high density of apocrine glands and characterized by subcutaneous nodules that may evolve into fistulas with pus secretion. Methods: The aim of this review is to investigate all current knowledge on cytokine regulation in the pathogenesis of HS. A systematic literature research using the words “cytokine”, “interleukin”, “pathway”, and “hidradenitis suppurativa” was performed in PubMed/Medline and Scopus/Embase databases. A search of the clinicaltrials.gov website for interventional recruiting and completed trials including the term “hidradenitis suppurativa” was also performed up to August 2020. We will discuss the pathogenetic role of various cytokines in HS and potential therapeutic targets for this debilitating disease. Results: The pathophysiology underlying this complex condition has not been clearly defined. An upregulation of various cytokines, such as tumor necrosis factor alpha (TNF-α), interleukin (IL)-1, IL-17, IL-23, and other molecules seems to be related to this inflammatory condition. Various cells, such as lymphocytes T Helper 1 and 17 and keratinocytes seem to be involved in the genesis of this condition. Conclusions: Several future studies and clinical trials are necessary in order to have new knowledge about HS and to properly treat this complex condition.https://www.mdpi.com/1422-0067/21/22/8436hidradenitis suppurativacytokineinterleukin |
| spellingShingle | Ester Del Duca Paola Morelli Luigi Bennardo Cosimo Di Raimondo Steven Paul Nisticò Cytokine Pathways and Investigational Target Therapies in Hidradenitis Suppurativa International Journal of Molecular Sciences hidradenitis suppurativa cytokine interleukin |
| title | Cytokine Pathways and Investigational Target Therapies in Hidradenitis Suppurativa |
| title_full | Cytokine Pathways and Investigational Target Therapies in Hidradenitis Suppurativa |
| title_fullStr | Cytokine Pathways and Investigational Target Therapies in Hidradenitis Suppurativa |
| title_full_unstemmed | Cytokine Pathways and Investigational Target Therapies in Hidradenitis Suppurativa |
| title_short | Cytokine Pathways and Investigational Target Therapies in Hidradenitis Suppurativa |
| title_sort | cytokine pathways and investigational target therapies in hidradenitis suppurativa |
| topic | hidradenitis suppurativa cytokine interleukin |
| url | https://www.mdpi.com/1422-0067/21/22/8436 |
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