Clinical characteristics of Guillain–Barre syndrome in COVID-19: a systematic review and meta-analysis of observational studies
Abstract Background Guillain–Barre syndrome (GBS) is a complication that occurs in patients with Coronavirus Disease (COVID-19) infection. The spectrum of symptoms varies from mild to severe symptoms, even death. The study aimed to compare the clinical manifestations in GBS patients with and without...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-03-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-023-00633-7 |
| _version_ | 1827974729400582144 |
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| author | I Gusti Agung Ayu Andra Yusari Putu Gede Sudira Dewa Putu Gde Purwa Samatra |
| author_facet | I Gusti Agung Ayu Andra Yusari Putu Gede Sudira Dewa Putu Gde Purwa Samatra |
| author_sort | I Gusti Agung Ayu Andra Yusari |
| collection | DOAJ |
| description | Abstract Background Guillain–Barre syndrome (GBS) is a complication that occurs in patients with Coronavirus Disease (COVID-19) infection. The spectrum of symptoms varies from mild to severe symptoms, even death. The study aimed to compare the clinical manifestations in GBS patients with and without COVID-19 comorbidity. Results A systematic review and meta-analysis of cohort and cross-sectional studies was conducted comparing the characteristics and course of GBS disease in the COVID-19 positive and COVID-19 negative groups. Four articles were selected with a total sample of 61 COVID-19 positive and 110 COVID-19 negative GBS patients. Based on clinical manifestations, COVID-19 infection increased the likelihood of tetraparesis (OR: 2.54; 95% CI 1.12–5.74; p = 0.03) and the presence of facial nerve involvement (OR: 2.34; 95% CI 1.00–5.47; p = 0.05). Demyelinating type GBS or AIDP was more common in the COVID-19 positive group (OR: 2.32; 95% CI 1.16–4.61; p = 0.02). COVID-19 in GBS significantly increased the need for intensive care (OR: 3.32; 95% CI 1.48–7.46; p = 0.004) and the use of mechanical ventilation (OR: 2.42; 95% CI 1.00–5.86; p = 0.05). Conclusions GBS following COVID-19 infection showed more severe variations in clinical characteristics compared to the group of GBS patients without COVID-19. Early detection of GBS, especially the typical manifestations post COVID-19 infection, is very important to carry out intensive monitoring and early management before the patient's condition worsens. |
| first_indexed | 2024-04-09T19:59:03Z |
| format | Article |
| id | doaj.art-d21ed9c2a66f40008669a6b508d082f1 |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-04-09T19:59:03Z |
| publishDate | 2023-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-d21ed9c2a66f40008669a6b508d082f12023-04-03T05:20:22ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292023-03-0159111410.1186/s41983-023-00633-7Clinical characteristics of Guillain–Barre syndrome in COVID-19: a systematic review and meta-analysis of observational studiesI Gusti Agung Ayu Andra Yusari0Putu Gede Sudira1Dewa Putu Gde Purwa Samatra2Faculty of Medicine, Universitas UdayanaDepartment of Neurology, Universitas Udayana HospitalDepartment of Neurology, Faculty of Medicine, Universitas Udayana/Prof. Dr. I.G.N.G. Ngoerah General HospitalAbstract Background Guillain–Barre syndrome (GBS) is a complication that occurs in patients with Coronavirus Disease (COVID-19) infection. The spectrum of symptoms varies from mild to severe symptoms, even death. The study aimed to compare the clinical manifestations in GBS patients with and without COVID-19 comorbidity. Results A systematic review and meta-analysis of cohort and cross-sectional studies was conducted comparing the characteristics and course of GBS disease in the COVID-19 positive and COVID-19 negative groups. Four articles were selected with a total sample of 61 COVID-19 positive and 110 COVID-19 negative GBS patients. Based on clinical manifestations, COVID-19 infection increased the likelihood of tetraparesis (OR: 2.54; 95% CI 1.12–5.74; p = 0.03) and the presence of facial nerve involvement (OR: 2.34; 95% CI 1.00–5.47; p = 0.05). Demyelinating type GBS or AIDP was more common in the COVID-19 positive group (OR: 2.32; 95% CI 1.16–4.61; p = 0.02). COVID-19 in GBS significantly increased the need for intensive care (OR: 3.32; 95% CI 1.48–7.46; p = 0.004) and the use of mechanical ventilation (OR: 2.42; 95% CI 1.00–5.86; p = 0.05). Conclusions GBS following COVID-19 infection showed more severe variations in clinical characteristics compared to the group of GBS patients without COVID-19. Early detection of GBS, especially the typical manifestations post COVID-19 infection, is very important to carry out intensive monitoring and early management before the patient's condition worsens.https://doi.org/10.1186/s41983-023-00633-7Guillain–Barre syndromeCOVID-19Clinical manifestation |
| spellingShingle | I Gusti Agung Ayu Andra Yusari Putu Gede Sudira Dewa Putu Gde Purwa Samatra Clinical characteristics of Guillain–Barre syndrome in COVID-19: a systematic review and meta-analysis of observational studies The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Guillain–Barre syndrome COVID-19 Clinical manifestation |
| title | Clinical characteristics of Guillain–Barre syndrome in COVID-19: a systematic review and meta-analysis of observational studies |
| title_full | Clinical characteristics of Guillain–Barre syndrome in COVID-19: a systematic review and meta-analysis of observational studies |
| title_fullStr | Clinical characteristics of Guillain–Barre syndrome in COVID-19: a systematic review and meta-analysis of observational studies |
| title_full_unstemmed | Clinical characteristics of Guillain–Barre syndrome in COVID-19: a systematic review and meta-analysis of observational studies |
| title_short | Clinical characteristics of Guillain–Barre syndrome in COVID-19: a systematic review and meta-analysis of observational studies |
| title_sort | clinical characteristics of guillain barre syndrome in covid 19 a systematic review and meta analysis of observational studies |
| topic | Guillain–Barre syndrome COVID-19 Clinical manifestation |
| url | https://doi.org/10.1186/s41983-023-00633-7 |
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