Tumor Cell‐Intrinsic CD96 Mediates Chemoresistance and Cancer Stemness by Regulating Mitochondrial Fatty Acid β‐Oxidation

Tumor Cell‐Intrinsic CD96 Mediates Chemoresistance and Cancer Stemness by Regulating Mitochondrial Fatty Acid β‐Oxidation

Abstract Targeting CD96 that originates in immune cells has shown potential for cancer therapy. However, the role of intrinsic CD96 in solid tumor cells remains unknown. Here, it is found that CD96 is frequently expressed in tumor cells from clinical breast cancer samples and is correlated with poor...

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Bibliographic Details
Main Authors: Jiang Li, Qidong Xia, Can Di, Chunni Li, Hang Si, Boxuan Zhou, Shubin Yu, Yihong Li, Jingying Huang, Yiwen Lu, Min Huang, Huixin Liang, Xinwei Liu, Qiyi Zhao
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:Advanced Science
Subjects:
cancer stem cells
CD96
chemoresistance
fatty acid β‐oxidation
mitochondrial remodeling
Online Access:https://doi.org/10.1002/advs.202202956

Internet

https://doi.org/10.1002/advs.202202956

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