Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent adverse effect of neurotoxic anticancer medicines. It leads to autonomic and somatic system dysfunction and decreases the patient’s quality of life. This side effect eventually causes chemotherapy non-compliance. Patients are prompted t...
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| Format: | Article |
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MDPI AG
2016-09-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/9/1252 |
| _version_ | 1818196481463549952 |
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| author | Gihyun Lee Sun Kwang Kim |
| author_facet | Gihyun Lee Sun Kwang Kim |
| author_sort | Gihyun Lee |
| collection | DOAJ |
| description | Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent adverse effect of neurotoxic anticancer medicines. It leads to autonomic and somatic system dysfunction and decreases the patient’s quality of life. This side effect eventually causes chemotherapy non-compliance. Patients are prompted to seek alternative treatment options since there is no conventional remedy for CIPN. A range of medicinal herbs have multifarious effects, and they have shown some evidence of efficacy in various neurological and immunological diseases. While CIPN has multiple mechanisms of neurotoxicity, these phytomedicines might offer neuronal protection or regeneration with the multiple targets in CIPN. Thus far, researchers have investigated the therapeutic benefits of several herbs, herbal formulas, and phytochemicals in preventing the onset and progress of CIPN in animals and humans. Here, we summarize current knowledge regarding the role of phytochemicals, herb extracts, and herbal formulas in alleviating CIPN. |
| first_indexed | 2024-12-12T01:34:46Z |
| format | Article |
| id | doaj.art-d221bbc6e61a4f1496ff5a2abc260815 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-12T01:34:46Z |
| publishDate | 2016-09-01 |
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| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d221bbc6e61a4f1496ff5a2abc2608152022-12-22T00:42:53ZengMDPI AGMolecules1420-30492016-09-01219125210.3390/molecules21091252molecules21091252Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral NeuropathyGihyun Lee0Sun Kwang Kim1Department of Physiology, College of Korean Medicine, Kyung Hee University, 26 Kyunghee-daero, Dongdaemoon-gu, Seoul 02447, KoreaDepartment of Physiology, College of Korean Medicine, Kyung Hee University, 26 Kyunghee-daero, Dongdaemoon-gu, Seoul 02447, KoreaChemotherapy-induced peripheral neuropathy (CIPN) is a frequent adverse effect of neurotoxic anticancer medicines. It leads to autonomic and somatic system dysfunction and decreases the patient’s quality of life. This side effect eventually causes chemotherapy non-compliance. Patients are prompted to seek alternative treatment options since there is no conventional remedy for CIPN. A range of medicinal herbs have multifarious effects, and they have shown some evidence of efficacy in various neurological and immunological diseases. While CIPN has multiple mechanisms of neurotoxicity, these phytomedicines might offer neuronal protection or regeneration with the multiple targets in CIPN. Thus far, researchers have investigated the therapeutic benefits of several herbs, herbal formulas, and phytochemicals in preventing the onset and progress of CIPN in animals and humans. Here, we summarize current knowledge regarding the role of phytochemicals, herb extracts, and herbal formulas in alleviating CIPN.http://www.mdpi.com/1420-3049/21/9/1252phytochemicalmedicinal herbchemotherapy-induced peripheral neuropathy |
| spellingShingle | Gihyun Lee Sun Kwang Kim Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy Molecules phytochemical medicinal herb chemotherapy-induced peripheral neuropathy |
| title | Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy |
| title_full | Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy |
| title_fullStr | Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy |
| title_full_unstemmed | Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy |
| title_short | Therapeutic Effects of Phytochemicals and Medicinal Herbs on Chemotherapy-Induced Peripheral Neuropathy |
| title_sort | therapeutic effects of phytochemicals and medicinal herbs on chemotherapy induced peripheral neuropathy |
| topic | phytochemical medicinal herb chemotherapy-induced peripheral neuropathy |
| url | http://www.mdpi.com/1420-3049/21/9/1252 |
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