Receptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune Diseases
As a critical molecule in the onset and sustainment of inflammatory response, the receptor for advanced glycation end products (RAGE) has a variety of ligands, such as advanced glycation end products (AGEs), S100/calcium granule protein, and high-mobility group protein 1 (HMGB1). Recently, an increa...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/15/4922 |
| _version_ | 1827625053524590592 |
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| author | Qing Yue Yu Song Zi Liu Lin Zhang Ling Yang Jinlong Li |
| author_facet | Qing Yue Yu Song Zi Liu Lin Zhang Ling Yang Jinlong Li |
| author_sort | Qing Yue |
| collection | DOAJ |
| description | As a critical molecule in the onset and sustainment of inflammatory response, the receptor for advanced glycation end products (RAGE) has a variety of ligands, such as advanced glycation end products (AGEs), S100/calcium granule protein, and high-mobility group protein 1 (HMGB1). Recently, an increasing number studies have shown that RAGE ligand binding can initiate the intracellular signal cascade, affect intracellular signal transduction, stimulate the release of cytokines, and play a vital role in the occurrence and development of immune-related diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and Alzheimer’s disease. In addition, other RAGE signaling pathways can play crucial roles in life activities, such as inflammation, apoptosis, autophagy, and endoplasmic reticulum stress. Therefore, the strategy of targeted intervention in the RAGE signaling pathway may have significant therapeutic potential, attracting increasing attention. In this paper, through the systematic induction and analysis of RAGE-related signaling pathways and their regulatory mechanisms in immune-related diseases, we provide theoretical clues for the follow-up targeted intervention of RAGE-mediated diseases. |
| first_indexed | 2024-03-09T12:21:13Z |
| format | Article |
| id | doaj.art-d221c244d261451a8ce01d97a6ede896 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T12:21:13Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
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| series | Molecules |
| spelling | doaj.art-d221c244d261451a8ce01d97a6ede8962023-11-30T22:40:56ZengMDPI AGMolecules1420-30492022-08-012715492210.3390/molecules27154922Receptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune DiseasesQing Yue0Yu Song1Zi Liu2Lin Zhang3Ling Yang4Jinlong Li5Hebei Key Laboratory for Organ Fibrosis Research, School of Public Health, North China University of Science and Technology, Tangshan 063210, ChinaHebei Key Laboratory for Organ Fibrosis Research, School of Public Health, North China University of Science and Technology, Tangshan 063210, ChinaHebei Key Laboratory for Organ Fibrosis Research, School of Public Health, North China University of Science and Technology, Tangshan 063210, ChinaDepartment of Internal Medicine Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu 241002, ChinaHebei Key Laboratory for Organ Fibrosis Research, School of Public Health, North China University of Science and Technology, Tangshan 063210, ChinaHebei Key Laboratory for Organ Fibrosis Research, School of Public Health, North China University of Science and Technology, Tangshan 063210, ChinaAs a critical molecule in the onset and sustainment of inflammatory response, the receptor for advanced glycation end products (RAGE) has a variety of ligands, such as advanced glycation end products (AGEs), S100/calcium granule protein, and high-mobility group protein 1 (HMGB1). Recently, an increasing number studies have shown that RAGE ligand binding can initiate the intracellular signal cascade, affect intracellular signal transduction, stimulate the release of cytokines, and play a vital role in the occurrence and development of immune-related diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and Alzheimer’s disease. In addition, other RAGE signaling pathways can play crucial roles in life activities, such as inflammation, apoptosis, autophagy, and endoplasmic reticulum stress. Therefore, the strategy of targeted intervention in the RAGE signaling pathway may have significant therapeutic potential, attracting increasing attention. In this paper, through the systematic induction and analysis of RAGE-related signaling pathways and their regulatory mechanisms in immune-related diseases, we provide theoretical clues for the follow-up targeted intervention of RAGE-mediated diseases.https://www.mdpi.com/1420-3049/27/15/4922advanced glycation end-product receptorimmunehigh-mobility group protein 1nuclear factor kappa-B |
| spellingShingle | Qing Yue Yu Song Zi Liu Lin Zhang Ling Yang Jinlong Li Receptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune Diseases Molecules advanced glycation end-product receptor immune high-mobility group protein 1 nuclear factor kappa-B |
| title | Receptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune Diseases |
| title_full | Receptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune Diseases |
| title_fullStr | Receptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune Diseases |
| title_full_unstemmed | Receptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune Diseases |
| title_short | Receptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune Diseases |
| title_sort | receptor for advanced glycation end products rage a pivotal hub in immune diseases |
| topic | advanced glycation end-product receptor immune high-mobility group protein 1 nuclear factor kappa-B |
| url | https://www.mdpi.com/1420-3049/27/15/4922 |
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