Plasma Cytokine Levels and Cytokine Genetic Polymorphisms in Patients with Metastatic Breast Cancer Receiving High-Dose Chemotherapy
Differences in the baseline levels of serum cytokines or in single-nucleotide polymorphisms (SNPs) in cytokine genes may be useful to predict outcomes for patients being treated for metastatic breast cancer. We have measured the plasma levels and characterized individual SNPs for IL-1RA, IL-1β, IL-2...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Immuno |
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| Online Access: | https://www.mdpi.com/2673-5601/3/1/2 |
| _version_ | 1797611129408585728 |
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| author | Robert Lafrenie Mary Bewick Carly Buckner Michael Conlon |
| author_facet | Robert Lafrenie Mary Bewick Carly Buckner Michael Conlon |
| author_sort | Robert Lafrenie |
| collection | DOAJ |
| description | Differences in the baseline levels of serum cytokines or in single-nucleotide polymorphisms (SNPs) in cytokine genes may be useful to predict outcomes for patients being treated for metastatic breast cancer. We have measured the plasma levels and characterized individual SNPs for IL-1RA, IL-1β, IL-2, IL-6 and TNFα in 130 patients with metastatic breast cancer treated with high-dose chemotherapy. Patients were treated with high-dose cyclophosphamide (Group 1, 74 patients) or high-dose paclitaxel-containing regimens (Group 2, 56 patients). A high plasma level of IL-1RA and a SNP in the IL-1RA gene indicated a better prognosis for patients in Group 1 (but not Group 2). However, the level of plasma IL-1RA did not correlate with the SNP genotype. A high plasma level of IL-6 or TNFα indicated a poorer outcome for patients in Group 1 although the SNP genotypes for the IL-6 and TNFα SNPs were not associated with differences in outcome. The plasma levels of IL-1β and IL-2 and the genotype of the IL-1β SNPs did not indicate differences in outcome. Although, individually, plasma levels of cytokine or “risk” SNP genotypes may not indicate outcome, in combination there was an increased trend to predict outcome for patients treated with high-dose cyclophosphamide but not high-dose paclitaxel. These results suggest that the immune cytokines may be useful as prognostic biomarkers in the treatment of patients with metastatic breast cancer treated with different types of chemotherapy. |
| first_indexed | 2024-03-11T06:24:28Z |
| format | Article |
| id | doaj.art-d22224d0eb10401bb5742db494a72ca8 |
| institution | Directory Open Access Journal |
| issn | 2673-5601 |
| language | English |
| last_indexed | 2024-03-11T06:24:28Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Immuno |
| spelling | doaj.art-d22224d0eb10401bb5742db494a72ca82023-11-17T11:43:08ZengMDPI AGImmuno2673-56012023-01-0131163410.3390/immuno3010002Plasma Cytokine Levels and Cytokine Genetic Polymorphisms in Patients with Metastatic Breast Cancer Receiving High-Dose ChemotherapyRobert Lafrenie0Mary Bewick1Carly Buckner2Michael Conlon3Health Sciences North Research Institute, Sudbury, ON P3E 2H3, CanadaHealth Sciences North Research Institute, Sudbury, ON P3E 2H3, CanadaHealth Sciences North Research Institute, Sudbury, ON P3E 2H3, CanadaHealth Sciences North Research Institute, Sudbury, ON P3E 2H3, CanadaDifferences in the baseline levels of serum cytokines or in single-nucleotide polymorphisms (SNPs) in cytokine genes may be useful to predict outcomes for patients being treated for metastatic breast cancer. We have measured the plasma levels and characterized individual SNPs for IL-1RA, IL-1β, IL-2, IL-6 and TNFα in 130 patients with metastatic breast cancer treated with high-dose chemotherapy. Patients were treated with high-dose cyclophosphamide (Group 1, 74 patients) or high-dose paclitaxel-containing regimens (Group 2, 56 patients). A high plasma level of IL-1RA and a SNP in the IL-1RA gene indicated a better prognosis for patients in Group 1 (but not Group 2). However, the level of plasma IL-1RA did not correlate with the SNP genotype. A high plasma level of IL-6 or TNFα indicated a poorer outcome for patients in Group 1 although the SNP genotypes for the IL-6 and TNFα SNPs were not associated with differences in outcome. The plasma levels of IL-1β and IL-2 and the genotype of the IL-1β SNPs did not indicate differences in outcome. Although, individually, plasma levels of cytokine or “risk” SNP genotypes may not indicate outcome, in combination there was an increased trend to predict outcome for patients treated with high-dose cyclophosphamide but not high-dose paclitaxel. These results suggest that the immune cytokines may be useful as prognostic biomarkers in the treatment of patients with metastatic breast cancer treated with different types of chemotherapy.https://www.mdpi.com/2673-5601/3/1/2breast cancerinterleukin-1 receptor antagonistcytokineschemotherapyprognosis |
| spellingShingle | Robert Lafrenie Mary Bewick Carly Buckner Michael Conlon Plasma Cytokine Levels and Cytokine Genetic Polymorphisms in Patients with Metastatic Breast Cancer Receiving High-Dose Chemotherapy Immuno breast cancer interleukin-1 receptor antagonist cytokines chemotherapy prognosis |
| title | Plasma Cytokine Levels and Cytokine Genetic Polymorphisms in Patients with Metastatic Breast Cancer Receiving High-Dose Chemotherapy |
| title_full | Plasma Cytokine Levels and Cytokine Genetic Polymorphisms in Patients with Metastatic Breast Cancer Receiving High-Dose Chemotherapy |
| title_fullStr | Plasma Cytokine Levels and Cytokine Genetic Polymorphisms in Patients with Metastatic Breast Cancer Receiving High-Dose Chemotherapy |
| title_full_unstemmed | Plasma Cytokine Levels and Cytokine Genetic Polymorphisms in Patients with Metastatic Breast Cancer Receiving High-Dose Chemotherapy |
| title_short | Plasma Cytokine Levels and Cytokine Genetic Polymorphisms in Patients with Metastatic Breast Cancer Receiving High-Dose Chemotherapy |
| title_sort | plasma cytokine levels and cytokine genetic polymorphisms in patients with metastatic breast cancer receiving high dose chemotherapy |
| topic | breast cancer interleukin-1 receptor antagonist cytokines chemotherapy prognosis |
| url | https://www.mdpi.com/2673-5601/3/1/2 |
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