| Summary: | A novel 4-chloro-6-(chloromethyl)-1-methyl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidine was prepared by a rational and short two-step synthesis from commercially available ethyl 5-amino-1-methyl-1<i>H</i>-pyrazole-4-carboxylate via 6-(chloromethyl)-1-methyl-1,5-dihydro-4<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-4-one. The structure of the synthesized compounds was established by elemental analysis, high-resolution mass-spectrometry, <sup>1</sup>H, <sup>13</sup>C-NMR and IR spectroscopy and mass-spectrometry. 4-Chloro-6-(chloromethyl)-1-methyl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidine is a convenient intermediate for various disubstituted 1-methyl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidines, which may be of interest as substances with useful pharmacological properties.
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