Association between COX-2 rs2745557 polymorphism and prostate cancer risk: a systematic review and meta-analysis
<p>Abstract</p> <p>Background</p> <p>Evidence is accumulating that chronic inflammation may have an important role in prostate cancer (PCa). The COX-2 polymorphism rs2745557 (+202 C/T) has been extensively investigated as a potential risk factor for PCa, but the results...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-03-01
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| Series: | BMC Immunology |
| Online Access: | http://www.biomedcentral.com/1471-2172/13/14 |
| _version_ | 1818058865205313536 |
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| author | Zhang Hongtuan Xu Yong Zhang Zhihong Liu Ranlu Ma Baojie |
| author_facet | Zhang Hongtuan Xu Yong Zhang Zhihong Liu Ranlu Ma Baojie |
| author_sort | Zhang Hongtuan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Evidence is accumulating that chronic inflammation may have an important role in prostate cancer (PCa). The COX-2 polymorphism rs2745557 (+202 C/T) has been extensively investigated as a potential risk factor for PCa, but the results have thus far been inconclusive. This meta-analysis was performed to derive a more precise estimation of the association.</p> <p>Methods</p> <p>A comprehensive search was conducted to identify all case-control studies of COX-2 rs2745557 polymorphism and PCa risk. We used odds ratios (ORs) to assess the strength of the association, and 95% confidence intervals (CIs) give a sense of the precision of the estimate. Statistical analyses were performed by Review Manage, version 5.0 and Stata 10.0.</p> <p>Results</p> <p>A total of 8 available studies were considered in the present meta-analysis, with 11356 patients and 11641 controls for rs2745557. When all groups were pooled, there was no evidence that rs2745557 had significant association with PCa under co-dominant, recessive, over-dominant, and allelic models. However, our analysis suggested that rs2745557 was associated with a lower PCa risk under dominant model in overall population (OR = 0.85, 95%CI = 0.74-0.97, P = 0.02). When stratifying for race, there was a significant association between rs2745557 polymorphism and lower PCa risk in dominant model comparison in the subgroup of Caucasians (OR = 0.86, 95%CI = 0.75-0.99, P = 0.04), but not in co-dominant, recessive, over-dominant and allelic comparisons.</p> <p>Conclusion</p> <p>Based on our meta-analysis, COX-2 rs2745557 was associated with a lower PCa risk under dominant model in Caucasians.</p> |
| first_indexed | 2024-12-10T13:07:25Z |
| format | Article |
| id | doaj.art-d224ef09664546bc9711ab7faf2a430d |
| institution | Directory Open Access Journal |
| issn | 1471-2172 |
| language | English |
| last_indexed | 2024-12-10T13:07:25Z |
| publishDate | 2012-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Immunology |
| spelling | doaj.art-d224ef09664546bc9711ab7faf2a430d2022-12-22T01:47:48ZengBMCBMC Immunology1471-21722012-03-011311410.1186/1471-2172-13-14Association between COX-2 rs2745557 polymorphism and prostate cancer risk: a systematic review and meta-analysisZhang HongtuanXu YongZhang ZhihongLiu RanluMa Baojie<p>Abstract</p> <p>Background</p> <p>Evidence is accumulating that chronic inflammation may have an important role in prostate cancer (PCa). The COX-2 polymorphism rs2745557 (+202 C/T) has been extensively investigated as a potential risk factor for PCa, but the results have thus far been inconclusive. This meta-analysis was performed to derive a more precise estimation of the association.</p> <p>Methods</p> <p>A comprehensive search was conducted to identify all case-control studies of COX-2 rs2745557 polymorphism and PCa risk. We used odds ratios (ORs) to assess the strength of the association, and 95% confidence intervals (CIs) give a sense of the precision of the estimate. Statistical analyses were performed by Review Manage, version 5.0 and Stata 10.0.</p> <p>Results</p> <p>A total of 8 available studies were considered in the present meta-analysis, with 11356 patients and 11641 controls for rs2745557. When all groups were pooled, there was no evidence that rs2745557 had significant association with PCa under co-dominant, recessive, over-dominant, and allelic models. However, our analysis suggested that rs2745557 was associated with a lower PCa risk under dominant model in overall population (OR = 0.85, 95%CI = 0.74-0.97, P = 0.02). When stratifying for race, there was a significant association between rs2745557 polymorphism and lower PCa risk in dominant model comparison in the subgroup of Caucasians (OR = 0.86, 95%CI = 0.75-0.99, P = 0.04), but not in co-dominant, recessive, over-dominant and allelic comparisons.</p> <p>Conclusion</p> <p>Based on our meta-analysis, COX-2 rs2745557 was associated with a lower PCa risk under dominant model in Caucasians.</p>http://www.biomedcentral.com/1471-2172/13/14 |
| spellingShingle | Zhang Hongtuan Xu Yong Zhang Zhihong Liu Ranlu Ma Baojie Association between COX-2 rs2745557 polymorphism and prostate cancer risk: a systematic review and meta-analysis BMC Immunology |
| title | Association between COX-2 rs2745557 polymorphism and prostate cancer risk: a systematic review and meta-analysis |
| title_full | Association between COX-2 rs2745557 polymorphism and prostate cancer risk: a systematic review and meta-analysis |
| title_fullStr | Association between COX-2 rs2745557 polymorphism and prostate cancer risk: a systematic review and meta-analysis |
| title_full_unstemmed | Association between COX-2 rs2745557 polymorphism and prostate cancer risk: a systematic review and meta-analysis |
| title_short | Association between COX-2 rs2745557 polymorphism and prostate cancer risk: a systematic review and meta-analysis |
| title_sort | association between cox 2 rs2745557 polymorphism and prostate cancer risk a systematic review and meta analysis |
| url | http://www.biomedcentral.com/1471-2172/13/14 |
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