Persistent representation of the environment in the hippocampus
Summary: In the hippocampus, environmental changes elicit rearrangement of active neuronal ensembles or remapping of place cells. However, it remains elusive how the brain ensures a consistent representation of a certain environment itself despite salient events occurring there. Here, we longitudina...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124722018939 |
| _version_ | 1828065360424730624 |
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| author | Kyogo S. Kobayashi Naoki Matsuo |
| author_facet | Kyogo S. Kobayashi Naoki Matsuo |
| author_sort | Kyogo S. Kobayashi |
| collection | DOAJ |
| description | Summary: In the hippocampus, environmental changes elicit rearrangement of active neuronal ensembles or remapping of place cells. However, it remains elusive how the brain ensures a consistent representation of a certain environment itself despite salient events occurring there. Here, we longitudinally tracked calcium dynamics of dorsal hippocampal CA1 neurons in mice subjected to contextual fear conditioning and extinction training. Overall population activities were significantly changed by fear conditioning and were responsive to footshocks and freezing. However, a small subset of neurons, termed environment cells, were consistently active in a specific environment irrespective of experiences. A decoder modeling study showed that these cells, but not place cells, were able to predict the environment to which the mouse was exposed. Environment cells might underlie the constancy of cognition for distinct environments across time and events. Additionally, our study highlights the functional heterogeneity of cells in the hippocampus. |
| first_indexed | 2024-04-10T23:13:45Z |
| format | Article |
| id | doaj.art-d226008da21c4985bb8e801a8be9a51f |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-10T23:13:45Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-d226008da21c4985bb8e801a8be9a51f2023-01-13T04:16:08ZengElsevierCell Reports2211-12472023-01-01421111989Persistent representation of the environment in the hippocampusKyogo S. Kobayashi0Naoki Matsuo1Department of Biology, Faculty of Science, Kyushu University, Fukuoka 819-0395, Japan; Corresponding authorDepartment of Biology, Faculty of Science, Kyushu University, Fukuoka 819-0395, Japan; Corresponding authorSummary: In the hippocampus, environmental changes elicit rearrangement of active neuronal ensembles or remapping of place cells. However, it remains elusive how the brain ensures a consistent representation of a certain environment itself despite salient events occurring there. Here, we longitudinally tracked calcium dynamics of dorsal hippocampal CA1 neurons in mice subjected to contextual fear conditioning and extinction training. Overall population activities were significantly changed by fear conditioning and were responsive to footshocks and freezing. However, a small subset of neurons, termed environment cells, were consistently active in a specific environment irrespective of experiences. A decoder modeling study showed that these cells, but not place cells, were able to predict the environment to which the mouse was exposed. Environment cells might underlie the constancy of cognition for distinct environments across time and events. Additionally, our study highlights the functional heterogeneity of cells in the hippocampus.http://www.sciencedirect.com/science/article/pii/S2211124722018939CP: Neuroscience |
| spellingShingle | Kyogo S. Kobayashi Naoki Matsuo Persistent representation of the environment in the hippocampus Cell Reports CP: Neuroscience |
| title | Persistent representation of the environment in the hippocampus |
| title_full | Persistent representation of the environment in the hippocampus |
| title_fullStr | Persistent representation of the environment in the hippocampus |
| title_full_unstemmed | Persistent representation of the environment in the hippocampus |
| title_short | Persistent representation of the environment in the hippocampus |
| title_sort | persistent representation of the environment in the hippocampus |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124722018939 |
| work_keys_str_mv | AT kyogoskobayashi persistentrepresentationoftheenvironmentinthehippocampus AT naokimatsuo persistentrepresentationoftheenvironmentinthehippocampus |