The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells
The paper gives the results of studying the genes of epidermal growth factor receptor (EGFR) and topoisomerase IIα (TOP IIα) in patients with triple-negative breast cancer (BC). It is suggested that the lack of EGFR gene amplification might serve as a factor of good prognosis. TOP IIα gene amplifica...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2014-08-01
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| Series: | Опухоли женской репродуктивной системы |
| Subjects: | |
| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/266 |
| _version_ | 1797876105769648128 |
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| author | D. A. Karseladze I. V. Poddubnaya A. I. Karseladze |
| author_facet | D. A. Karseladze I. V. Poddubnaya A. I. Karseladze |
| author_sort | D. A. Karseladze |
| collection | DOAJ |
| description | The paper gives the results of studying the genes of epidermal growth factor receptor (EGFR) and topoisomerase IIα (TOP IIα) in patients with triple-negative breast cancer (BC). It is suggested that the lack of EGFR gene amplification might serve as a factor of good prognosis. TOP IIα gene amplification usually occurs in the tumors responsive to chemotherapy including anthracycline drugs. The altered status of the above genes should be interpreted in the context of aneusomy of chromosomes 7 and 17, on which they are located. No association was found between the pattern of EGFR and TOP IIα gene abnormalities and the basaloid phenotype of BC. |
| first_indexed | 2024-04-10T01:58:01Z |
| format | Article |
| id | doaj.art-d226a0ab29b949969f7a5c70b7014236 |
| institution | Directory Open Access Journal |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| last_indexed | 2024-04-10T01:58:01Z |
| publishDate | 2014-08-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj.art-d226a0ab29b949969f7a5c70b70142362023-03-13T08:44:33ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272014-08-0104333910.17650/1994-4098-2010-0-4-33-39282The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cellsD. A. Karseladze0I. V. Poddubnaya1A. I. Karseladze2ГУ РОНЦ им. Н.Н. Блохина РАМНКафедра онкологии ГОУ ДПО РМАПО РосздраваОтдел патологической анатомии опухолей человека ГУ РОНЦ им. Н.Н. Блохина РАМН, МоскваThe paper gives the results of studying the genes of epidermal growth factor receptor (EGFR) and topoisomerase IIα (TOP IIα) in patients with triple-negative breast cancer (BC). It is suggested that the lack of EGFR gene amplification might serve as a factor of good prognosis. TOP IIα gene amplification usually occurs in the tumors responsive to chemotherapy including anthracycline drugs. The altered status of the above genes should be interpreted in the context of aneusomy of chromosomes 7 and 17, on which they are located. No association was found between the pattern of EGFR and TOP IIα gene abnormalities and the basaloid phenotype of BC.https://ojrs.abvpress.ru/ojrs/article/view/266тройной негативный рак молочной железытопоизомераза iiαрецептор эпидермального фактора ростаанеусомия хромосом 7 и 17 |
| spellingShingle | D. A. Karseladze I. V. Poddubnaya A. I. Karseladze The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells Опухоли женской репродуктивной системы тройной негативный рак молочной железы топоизомераза iiα рецептор эпидермального фактора роста анеусомия хромосом 7 и 17 |
| title | The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells |
| title_full | The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells |
| title_fullStr | The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells |
| title_full_unstemmed | The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells |
| title_short | The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells |
| title_sort | status of epidermal growth factor receptor and topoisomerase iiα genes in triple negative breast cancer cells |
| topic | тройной негативный рак молочной железы топоизомераза iiα рецептор эпидермального фактора роста анеусомия хромосом 7 и 17 |
| url | https://ojrs.abvpress.ru/ojrs/article/view/266 |
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