Acute toxicity study of Dermabin
The problem of improving the therapy of patients with psoriasis and psoriatic arthritis still remains to be one of the most pressing in the up-to-date dermatology, despite a considerable number of the available and newly appeared medications. The aim of research. The purpose of our study was to...
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| Format: | Article |
| Language: | English |
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Zaporozhye State Medical University
2017-04-01
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| Series: | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| Subjects: | |
| Online Access: | http://pharmed.zsmu.edu.ua/article/view/93456/90551 |
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| author | V. L. Karbovskyy I. A. Shevchuk O. V. Kurkina T. Ye. Makovska |
| author_facet | V. L. Karbovskyy I. A. Shevchuk O. V. Kurkina T. Ye. Makovska |
| author_sort | V. L. Karbovskyy |
| collection | DOAJ |
| description | The problem of improving the therapy of patients with psoriasis and psoriatic arthritis still remains to be one of the most pressing in the up-to-date dermatology, despite a considerable number of the available and newly appeared medications.
The aim of research. The purpose of our study was to explore the safety of Dermabin use in experiments on animals.
Materials and methods. The studies of drug Dermabin acute toxicity under the conditions of its single epicutaneous application at a dose of 3300mg/kg (betamethasone – 1.65 mg/kg, salicylic acid – 100 mg/kg) or single intragastric administration at a dose of 20000 mg/kg (betamethasone – 10 mg/kg, salicylic acid – 600 mg/kg) were carried out on 40 sexually mature rats of both sexes and 40 sexually mature mice of both sexes. The effect of drug Dermabin was evaluated by the following indicators: a) lethality (term animal deaths in each groups, daily); b) toxicity (daily), including irritation, edema and hyperemia in the area of application; c) body weight changes (days 0, 4, 7 and 14); d) macroscopic examination of innards and calculation of their mass coefficients (14 days).
Results. The study results showed that both during the epicutaneous application and intragastric administration of drug Dermabin, signs of intoxication in rats and mice were not revealed. The application of drug Dermabin has no effect on body weight dynamics, integrative indicators of functional status of the animals and a relative mass of their innards.
Conclusions. The study shows that LD50 for Dermabin drug while epicutaneously application and intragastrically administration to rats and mice is beyond the limits of 15000 mg/kg. According to toxicological classification of substances, drug Dermabin belongs to V class of toxicity – practically nontoxic substances. |
| first_indexed | 2024-12-10T16:40:40Z |
| format | Article |
| id | doaj.art-d22776149c944abc9aa6837748e5a8eb |
| institution | Directory Open Access Journal |
| issn | 2306-8094 2409-2932 |
| language | English |
| last_indexed | 2024-12-10T16:40:40Z |
| publishDate | 2017-04-01 |
| publisher | Zaporozhye State Medical University |
| record_format | Article |
| series | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| spelling | doaj.art-d22776149c944abc9aa6837748e5a8eb2022-12-22T01:41:15ZengZaporozhye State Medical UniversityAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki2306-80942409-29322017-04-01111612010.14739/2409-2932.2017.1.93456Acute toxicity study of DermabinV. L. KarbovskyyI. A. ShevchukO. V. KurkinaT. Ye. MakovskaThe problem of improving the therapy of patients with psoriasis and psoriatic arthritis still remains to be one of the most pressing in the up-to-date dermatology, despite a considerable number of the available and newly appeared medications. The aim of research. The purpose of our study was to explore the safety of Dermabin use in experiments on animals. Materials and methods. The studies of drug Dermabin acute toxicity under the conditions of its single epicutaneous application at a dose of 3300mg/kg (betamethasone – 1.65 mg/kg, salicylic acid – 100 mg/kg) or single intragastric administration at a dose of 20000 mg/kg (betamethasone – 10 mg/kg, salicylic acid – 600 mg/kg) were carried out on 40 sexually mature rats of both sexes and 40 sexually mature mice of both sexes. The effect of drug Dermabin was evaluated by the following indicators: a) lethality (term animal deaths in each groups, daily); b) toxicity (daily), including irritation, edema and hyperemia in the area of application; c) body weight changes (days 0, 4, 7 and 14); d) macroscopic examination of innards and calculation of their mass coefficients (14 days). Results. The study results showed that both during the epicutaneous application and intragastric administration of drug Dermabin, signs of intoxication in rats and mice were not revealed. The application of drug Dermabin has no effect on body weight dynamics, integrative indicators of functional status of the animals and a relative mass of their innards. Conclusions. The study shows that LD50 for Dermabin drug while epicutaneously application and intragastrically administration to rats and mice is beyond the limits of 15000 mg/kg. According to toxicological classification of substances, drug Dermabin belongs to V class of toxicity – practically nontoxic substances.http://pharmed.zsmu.edu.ua/article/view/93456/90551psoriasisdermatosisDermabinacute toxicity |
| spellingShingle | V. L. Karbovskyy I. A. Shevchuk O. V. Kurkina T. Ye. Makovska Acute toxicity study of Dermabin Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki psoriasis dermatosis Dermabin acute toxicity |
| title | Acute toxicity study of Dermabin |
| title_full | Acute toxicity study of Dermabin |
| title_fullStr | Acute toxicity study of Dermabin |
| title_full_unstemmed | Acute toxicity study of Dermabin |
| title_short | Acute toxicity study of Dermabin |
| title_sort | acute toxicity study of dermabin |
| topic | psoriasis dermatosis Dermabin acute toxicity |
| url | http://pharmed.zsmu.edu.ua/article/view/93456/90551 |
| work_keys_str_mv | AT vlkarbovskyy acutetoxicitystudyofdermabin AT iashevchuk acutetoxicitystudyofdermabin AT ovkurkina acutetoxicitystudyofdermabin AT tyemakovska acutetoxicitystudyofdermabin |