Consanguinity and congenital heart disease in offspring
Background Congenital heart disease (CHD) is a common congenital abnormality in children. Consanguineous marriage has been identified as a risk factor of CHD. There was an autosomal recessive pattern of inheritance seen in children with some forms of congenital heart disease. Objective To assess t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2018-04-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/999 |
| _version_ | 1818156225989181440 |
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| author | Aris Fazeriandy Muhammad Ali Johannes H. Saing Tina Christina L. Tobing Rizky Adriansyah |
| author_facet | Aris Fazeriandy Muhammad Ali Johannes H. Saing Tina Christina L. Tobing Rizky Adriansyah |
| author_sort | Aris Fazeriandy |
| collection | DOAJ |
| description | Background Congenital heart disease (CHD) is a common congenital abnormality in children. Consanguineous marriage has been identified as a risk factor of CHD. There was an autosomal recessive pattern of inheritance seen in children with some forms of congenital heart disease.
Objective To assess the possible association between consanguineous marriage and congenital heart disease incidence in the offspring.
Methods A case-control study was conducted from March to May 2016 on pediatric patients at H. Adam Malik General Hospital, Medan. Subjects were allocated into two groups, 100 children with CHD in the case group, and the rest in the control group. Data were analyzed using Chi-square and logistic regression tests. In the present study, P value less than 0.05 was considered statistically significant.
Results In the case group, 14 patients (14%) were born of consanguineous marriages. In the control group, only 5 patients (5%) were born of consanguineous marriages. There was a significant association between consanguineous marriage and CHD (OR 1.551; 95%CI 1.138 to 2.113). Based on the result of multivariate analysis, consanguineous marriage was a risk factor for CHD in offspring (Wald=4.525; P=0.033).
Conclusion Consanguineous marriage is a risk factor for CHD in offspring. |
| first_indexed | 2024-12-11T14:54:55Z |
| format | Article |
| id | doaj.art-d2281447f6f34fa5bb2c658a6b9c2cde |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-11T14:54:55Z |
| publishDate | 2018-04-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-d2281447f6f34fa5bb2c658a6b9c2cde2022-12-22T01:01:21ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2018-04-0158275910.14238/pi58.2.2018.75-9999Consanguinity and congenital heart disease in offspringAris Fazeriandy0Muhammad Ali1Johannes H. Saing2Tina Christina L. Tobing3Rizky Adriansyah4Department of Child Health, University of Sumatera Utara Medical School/H. Adam Malik Hospital, Medan, North SumateraDepartment of Child Health, University of Sumatera Utara Medical School/H. Adam Malik Hospital, Medan, North SumateraDepartment of Child Health, University of Sumatera Utara Medical School/H. Adam Malik Hospital, Medan, North SumateraDepartment of Child Health, University of Sumatera Utara Medical School/H. Adam Malik Hospital, Medan, North SumateraDepartment of Child Health, University of Sumatera Utara Medical School/H. Adam Malik Hospital, Medan, North SumateraBackground Congenital heart disease (CHD) is a common congenital abnormality in children. Consanguineous marriage has been identified as a risk factor of CHD. There was an autosomal recessive pattern of inheritance seen in children with some forms of congenital heart disease. Objective To assess the possible association between consanguineous marriage and congenital heart disease incidence in the offspring. Methods A case-control study was conducted from March to May 2016 on pediatric patients at H. Adam Malik General Hospital, Medan. Subjects were allocated into two groups, 100 children with CHD in the case group, and the rest in the control group. Data were analyzed using Chi-square and logistic regression tests. In the present study, P value less than 0.05 was considered statistically significant. Results In the case group, 14 patients (14%) were born of consanguineous marriages. In the control group, only 5 patients (5%) were born of consanguineous marriages. There was a significant association between consanguineous marriage and CHD (OR 1.551; 95%CI 1.138 to 2.113). Based on the result of multivariate analysis, consanguineous marriage was a risk factor for CHD in offspring (Wald=4.525; P=0.033). Conclusion Consanguineous marriage is a risk factor for CHD in offspring.https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/999consanguineous marriagecongenital heart diseasechildren |
| spellingShingle | Aris Fazeriandy Muhammad Ali Johannes H. Saing Tina Christina L. Tobing Rizky Adriansyah Consanguinity and congenital heart disease in offspring Paediatrica Indonesiana consanguineous marriage congenital heart disease children |
| title | Consanguinity and congenital heart disease in offspring |
| title_full | Consanguinity and congenital heart disease in offspring |
| title_fullStr | Consanguinity and congenital heart disease in offspring |
| title_full_unstemmed | Consanguinity and congenital heart disease in offspring |
| title_short | Consanguinity and congenital heart disease in offspring |
| title_sort | consanguinity and congenital heart disease in offspring |
| topic | consanguineous marriage congenital heart disease children |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/999 |
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