From Viral Infection to Autoimmune Reaction: Exploring the Link between Human Herpesvirus 6 and Autoimmune Diseases
The complexity of autoimmunity initiation has been the subject of many studies. Both genetic and environmental factors are essential in autoimmunity development. Among others, environmental factors include infectious agents. HHV-6 is a ubiquitous human pathogen with a high global prevalence. It has...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/12/2/362 |
| _version_ | 1797297438569005056 |
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| author | Liba Sokolovska Maksims Cistjakovs Asnate Matroze Modra Murovska Alina Sultanova |
| author_facet | Liba Sokolovska Maksims Cistjakovs Asnate Matroze Modra Murovska Alina Sultanova |
| author_sort | Liba Sokolovska |
| collection | DOAJ |
| description | The complexity of autoimmunity initiation has been the subject of many studies. Both genetic and environmental factors are essential in autoimmunity development. Among others, environmental factors include infectious agents. HHV-6 is a ubiquitous human pathogen with a high global prevalence. It has several properties suggestive of its contribution to autoimmunity development. HHV-6 has a broad cell tropism, the ability to establish latency with subsequent reactivation and persistence, and a range of immunomodulation capabilities. Studies have implicated HHV-6 in a plethora of autoimmune diseases—endocrine, neurological, connective tissue, and others—with some studies even proposing possible autoimmunity induction mechanisms. HHV-6 can be frequently found in autoimmunity-affected tissues and lesions; it has been found to infect autoimmune-pathology-relevant cells and influence immune responses and signaling. This review highlights some of the most well-known autoimmune conditions to which HHV-6 has been linked, like multiple sclerosis and autoimmune thyroiditis, and summarizes the data on HHV-6 involvement in autoimmunity development. |
| first_indexed | 2024-03-07T22:21:15Z |
| format | Article |
| id | doaj.art-d2283a0f36a249ed9f40e3a1553c2bf7 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-07T22:21:15Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-d2283a0f36a249ed9f40e3a1553c2bf72024-02-23T15:28:20ZengMDPI AGMicroorganisms2076-26072024-02-0112236210.3390/microorganisms12020362From Viral Infection to Autoimmune Reaction: Exploring the Link between Human Herpesvirus 6 and Autoimmune DiseasesLiba Sokolovska0Maksims Cistjakovs1Asnate Matroze2Modra Murovska3Alina Sultanova4Institute of Microbiology and Virology, Riga Stradins University, LV-1067 Riga, LatviaInstitute of Microbiology and Virology, Riga Stradins University, LV-1067 Riga, LatviaFaculty of Residency, Riga Stradins University, LV-1007 Riga, LatviaInstitute of Microbiology and Virology, Riga Stradins University, LV-1067 Riga, LatviaInstitute of Microbiology and Virology, Riga Stradins University, LV-1067 Riga, LatviaThe complexity of autoimmunity initiation has been the subject of many studies. Both genetic and environmental factors are essential in autoimmunity development. Among others, environmental factors include infectious agents. HHV-6 is a ubiquitous human pathogen with a high global prevalence. It has several properties suggestive of its contribution to autoimmunity development. HHV-6 has a broad cell tropism, the ability to establish latency with subsequent reactivation and persistence, and a range of immunomodulation capabilities. Studies have implicated HHV-6 in a plethora of autoimmune diseases—endocrine, neurological, connective tissue, and others—with some studies even proposing possible autoimmunity induction mechanisms. HHV-6 can be frequently found in autoimmunity-affected tissues and lesions; it has been found to infect autoimmune-pathology-relevant cells and influence immune responses and signaling. This review highlights some of the most well-known autoimmune conditions to which HHV-6 has been linked, like multiple sclerosis and autoimmune thyroiditis, and summarizes the data on HHV-6 involvement in autoimmunity development.https://www.mdpi.com/2076-2607/12/2/362HHV-6human herpesvirus 6autoimmunityautoimmune diseasemultiple sclerosissystemic sclerosis |
| spellingShingle | Liba Sokolovska Maksims Cistjakovs Asnate Matroze Modra Murovska Alina Sultanova From Viral Infection to Autoimmune Reaction: Exploring the Link between Human Herpesvirus 6 and Autoimmune Diseases Microorganisms HHV-6 human herpesvirus 6 autoimmunity autoimmune disease multiple sclerosis systemic sclerosis |
| title | From Viral Infection to Autoimmune Reaction: Exploring the Link between Human Herpesvirus 6 and Autoimmune Diseases |
| title_full | From Viral Infection to Autoimmune Reaction: Exploring the Link between Human Herpesvirus 6 and Autoimmune Diseases |
| title_fullStr | From Viral Infection to Autoimmune Reaction: Exploring the Link between Human Herpesvirus 6 and Autoimmune Diseases |
| title_full_unstemmed | From Viral Infection to Autoimmune Reaction: Exploring the Link between Human Herpesvirus 6 and Autoimmune Diseases |
| title_short | From Viral Infection to Autoimmune Reaction: Exploring the Link between Human Herpesvirus 6 and Autoimmune Diseases |
| title_sort | from viral infection to autoimmune reaction exploring the link between human herpesvirus 6 and autoimmune diseases |
| topic | HHV-6 human herpesvirus 6 autoimmunity autoimmune disease multiple sclerosis systemic sclerosis |
| url | https://www.mdpi.com/2076-2607/12/2/362 |
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