Unfolded protein response activated by endoplasmic reticulum stress in pancreatic cancer: potential therapeutical target
Pancreatic cancer is still one of the most perilous malignant tumors with a very poor prognosis. Despite the progress in the diagnosis and treatment of pancreatic cancer, the overall 5-year survival rate after diagnosis is less than 10%. The pathogenesis of pancreatic cancer has not been fully clari...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2021-12-01
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| Series: | Frontiers in Bioscience-Landmark |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBL/26/12/10.52586/5061 |
| _version_ | 1818774553017450496 |
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| author | Di Long Kai Chen Yinmo Yang Xiaodong Tian |
| author_facet | Di Long Kai Chen Yinmo Yang Xiaodong Tian |
| author_sort | Di Long |
| collection | DOAJ |
| description | Pancreatic cancer is still one of the most perilous malignant tumors with a very poor prognosis. Despite the progress in the diagnosis and treatment of pancreatic cancer, the overall 5-year survival rate after diagnosis is less than 10%. The pathogenesis of pancreatic cancer has not been fully clarified, but multiple factors are involved. The poor efficacy of traditional therapies for pancreatic cancer is mainly related to complex tumor microenvironment. In recent years, accumulating studies have demonstrated the role of autophagy and apoptosis triggered by endoplasmic reticulum stress in pancreatic cancer. In particular, unfolded protein response is activated by endoplasmic reticulum stress and plays an important role in the modulation of complex pancreatic tumor microenvironment. Here we summarize recent progress in our understanding of the role of unfolded protein response activated by endoplasmic reticulum stress in tumorigenesis of pancreatic cancer, and highlight the potential of the cascade of unfolded protein response as therapeutic target for pancreatic cancer. |
| first_indexed | 2024-12-18T10:42:58Z |
| format | Article |
| id | doaj.art-d22992a112cc406a863e2e137a6cac7e |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-12-18T10:42:58Z |
| publishDate | 2021-12-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-d22992a112cc406a863e2e137a6cac7e2022-12-21T21:10:36ZengIMR PressFrontiers in Bioscience-Landmark2768-67012021-12-0126121689169610.52586/5061S2768-6701(21)00302-6Unfolded protein response activated by endoplasmic reticulum stress in pancreatic cancer: potential therapeutical targetDi Long0Kai Chen1Yinmo Yang2Xiaodong Tian3Department of General Surgery, Peking University First Hospital, 100034 Beijing, ChinaDepartment of General Surgery, Peking University First Hospital, 100034 Beijing, ChinaDepartment of General Surgery, Peking University First Hospital, 100034 Beijing, ChinaDepartment of General Surgery, Peking University First Hospital, 100034 Beijing, ChinaPancreatic cancer is still one of the most perilous malignant tumors with a very poor prognosis. Despite the progress in the diagnosis and treatment of pancreatic cancer, the overall 5-year survival rate after diagnosis is less than 10%. The pathogenesis of pancreatic cancer has not been fully clarified, but multiple factors are involved. The poor efficacy of traditional therapies for pancreatic cancer is mainly related to complex tumor microenvironment. In recent years, accumulating studies have demonstrated the role of autophagy and apoptosis triggered by endoplasmic reticulum stress in pancreatic cancer. In particular, unfolded protein response is activated by endoplasmic reticulum stress and plays an important role in the modulation of complex pancreatic tumor microenvironment. Here we summarize recent progress in our understanding of the role of unfolded protein response activated by endoplasmic reticulum stress in tumorigenesis of pancreatic cancer, and highlight the potential of the cascade of unfolded protein response as therapeutic target for pancreatic cancer.https://www.imrpress.com/journal/FBL/26/12/10.52586/5061endoplasmic reticulum stressunfolded protein responsepancreatic cancerapoptosis |
| spellingShingle | Di Long Kai Chen Yinmo Yang Xiaodong Tian Unfolded protein response activated by endoplasmic reticulum stress in pancreatic cancer: potential therapeutical target Frontiers in Bioscience-Landmark endoplasmic reticulum stress unfolded protein response pancreatic cancer apoptosis |
| title | Unfolded protein response activated by endoplasmic reticulum stress in pancreatic cancer: potential therapeutical target |
| title_full | Unfolded protein response activated by endoplasmic reticulum stress in pancreatic cancer: potential therapeutical target |
| title_fullStr | Unfolded protein response activated by endoplasmic reticulum stress in pancreatic cancer: potential therapeutical target |
| title_full_unstemmed | Unfolded protein response activated by endoplasmic reticulum stress in pancreatic cancer: potential therapeutical target |
| title_short | Unfolded protein response activated by endoplasmic reticulum stress in pancreatic cancer: potential therapeutical target |
| title_sort | unfolded protein response activated by endoplasmic reticulum stress in pancreatic cancer potential therapeutical target |
| topic | endoplasmic reticulum stress unfolded protein response pancreatic cancer apoptosis |
| url | https://www.imrpress.com/journal/FBL/26/12/10.52586/5061 |
| work_keys_str_mv | AT dilong unfoldedproteinresponseactivatedbyendoplasmicreticulumstressinpancreaticcancerpotentialtherapeuticaltarget AT kaichen unfoldedproteinresponseactivatedbyendoplasmicreticulumstressinpancreaticcancerpotentialtherapeuticaltarget AT yinmoyang unfoldedproteinresponseactivatedbyendoplasmicreticulumstressinpancreaticcancerpotentialtherapeuticaltarget AT xiaodongtian unfoldedproteinresponseactivatedbyendoplasmicreticulumstressinpancreaticcancerpotentialtherapeuticaltarget |