The association of serum RANKL levels with disease activity and hematological parameters in Syrian patients with rheumatoid arthritis
Our study aims to detect whether the serum RANKL could be a novel potential biomarker for activity and diagnosis of rheumatoid arthritis (RA). It included fifty-eight of RA patients and thirty of equal age and sex matched controls. Disease activity was determined by using DAS28-ESR. Serum Levels of...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
|
| Series: | Biochemistry and Biophysics Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S240558082200173X |
| _version_ | 1828338240303661056 |
|---|---|
| author | Rama Hussein Imad Aboukhamis |
| author_facet | Rama Hussein Imad Aboukhamis |
| author_sort | Rama Hussein |
| collection | DOAJ |
| description | Our study aims to detect whether the serum RANKL could be a novel potential biomarker for activity and diagnosis of rheumatoid arthritis (RA). It included fifty-eight of RA patients and thirty of equal age and sex matched controls. Disease activity was determined by using DAS28-ESR. Serum Levels of RANKL were assayed by ELISA and compared with parameters such as ESR, CRP, Rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibodies (ACPA). The serum RANKL levels were higher in RA patients compared to controls. There was an increase in its levels mean among post-menopausal patients compared to post-menopausal healthy group. RANKL levels were also higher in ACPA positive patients than ACPA negative. Our study found a correlation between RANKL levels and some parameters: DAS28, ACPA, CRP, and symptom duration. There was a moderate inverse correlation between RANKL levels and BMD. By ROC curve, our results displayed that the best cut-off value of RANKL was 178.99 pg/ml (sensitivity 79.31%; specificity 90%) to differentiate between RA patients and controls. In conclusion, elevated serum RANKL can be used as an indicator of disease activity and a diagnostic new biomarker in patients with early RA. |
| first_indexed | 2024-04-13T22:26:12Z |
| format | Article |
| id | doaj.art-d22b8ef69a944025addc3255c0fe5e3f |
| institution | Directory Open Access Journal |
| issn | 2405-5808 |
| language | English |
| last_indexed | 2024-04-13T22:26:12Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj.art-d22b8ef69a944025addc3255c0fe5e3f2022-12-22T02:27:04ZengElsevierBiochemistry and Biophysics Reports2405-58082022-12-0132101373The association of serum RANKL levels with disease activity and hematological parameters in Syrian patients with rheumatoid arthritisRama Hussein0Imad Aboukhamis1Department of Microbiology, Hematology and Immunology, Faculty of Pharmacy, Damascus University, Syria; Corresponding author.Department of Microbiology, Hematology and Immunology, Faculty of Pharmacy, Damascus University, Syria; Department of Hematology and Immunology, Faculty of Pharmacy, Damascus University, SyriaOur study aims to detect whether the serum RANKL could be a novel potential biomarker for activity and diagnosis of rheumatoid arthritis (RA). It included fifty-eight of RA patients and thirty of equal age and sex matched controls. Disease activity was determined by using DAS28-ESR. Serum Levels of RANKL were assayed by ELISA and compared with parameters such as ESR, CRP, Rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibodies (ACPA). The serum RANKL levels were higher in RA patients compared to controls. There was an increase in its levels mean among post-menopausal patients compared to post-menopausal healthy group. RANKL levels were also higher in ACPA positive patients than ACPA negative. Our study found a correlation between RANKL levels and some parameters: DAS28, ACPA, CRP, and symptom duration. There was a moderate inverse correlation between RANKL levels and BMD. By ROC curve, our results displayed that the best cut-off value of RANKL was 178.99 pg/ml (sensitivity 79.31%; specificity 90%) to differentiate between RA patients and controls. In conclusion, elevated serum RANKL can be used as an indicator of disease activity and a diagnostic new biomarker in patients with early RA.http://www.sciencedirect.com/science/article/pii/S240558082200173XRheumatoid arthritisSerum RANKLDisease activityParameters |
| spellingShingle | Rama Hussein Imad Aboukhamis The association of serum RANKL levels with disease activity and hematological parameters in Syrian patients with rheumatoid arthritis Biochemistry and Biophysics Reports Rheumatoid arthritis Serum RANKL Disease activity Parameters |
| title | The association of serum RANKL levels with disease activity and hematological parameters in Syrian patients with rheumatoid arthritis |
| title_full | The association of serum RANKL levels with disease activity and hematological parameters in Syrian patients with rheumatoid arthritis |
| title_fullStr | The association of serum RANKL levels with disease activity and hematological parameters in Syrian patients with rheumatoid arthritis |
| title_full_unstemmed | The association of serum RANKL levels with disease activity and hematological parameters in Syrian patients with rheumatoid arthritis |
| title_short | The association of serum RANKL levels with disease activity and hematological parameters in Syrian patients with rheumatoid arthritis |
| title_sort | association of serum rankl levels with disease activity and hematological parameters in syrian patients with rheumatoid arthritis |
| topic | Rheumatoid arthritis Serum RANKL Disease activity Parameters |
| url | http://www.sciencedirect.com/science/article/pii/S240558082200173X |
| work_keys_str_mv | AT ramahussein theassociationofserumrankllevelswithdiseaseactivityandhematologicalparametersinsyrianpatientswithrheumatoidarthritis AT imadaboukhamis theassociationofserumrankllevelswithdiseaseactivityandhematologicalparametersinsyrianpatientswithrheumatoidarthritis AT ramahussein associationofserumrankllevelswithdiseaseactivityandhematologicalparametersinsyrianpatientswithrheumatoidarthritis AT imadaboukhamis associationofserumrankllevelswithdiseaseactivityandhematologicalparametersinsyrianpatientswithrheumatoidarthritis |