Adherence to and Persistence with Adalimumab Therapy among Swedish Patients with Crohn’s Disease
Objectives: (1) to determine the adherence and persistence rates of adalimumab therapy among Swedish patients with Crohn’s disease (CD), and (2) to compare self-administration devices to predict the medication adherence and persistence. Methods: We conducted a retrospective analysis of the Swedish N...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Pharmacy |
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| Online Access: | https://www.mdpi.com/2226-4787/10/4/87 |
| _version_ | 1797408401233281024 |
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| author | Yifei Liu Joakim Söderberg Jingdong Chao |
| author_facet | Yifei Liu Joakim Söderberg Jingdong Chao |
| author_sort | Yifei Liu |
| collection | DOAJ |
| description | Objectives: (1) to determine the adherence and persistence rates of adalimumab therapy among Swedish patients with Crohn’s disease (CD), and (2) to compare self-administration devices to predict the medication adherence and persistence. Methods: We conducted a retrospective analysis of the Swedish National Board of Health and Welfare database during a unique time period, when both the pen and the syringe were available. The pen was proposed to indicate a larger extent of internal control, according to health locus of control. Medication adherence was defined as a medication possession ratio (MPR) ≥ 0.8. A patient was considered nonpersistent if the time between any two dispensing records, minus the days of supply dispensed exceeded 180 days. The predictors of adherence were evaluated using a logistic regression, and the predictors of persistence were evaluated using a Cox proportional hazards model. Results: Among the 1083 patients studied, 89% were adherent and 77% were persistent. The patients using the pen and the patients treated in gastroenterology centers were more likely to be adherent and less likely to be nonpersistent. Conclusions: The adherence rate to adalimumab therapy was 89% and the one-year persistence rate was 70%. The pen and treatment in a gastroenterology center had a positive impact on the adherence and persistence among Swedish patients with CD. |
| first_indexed | 2024-03-09T03:57:57Z |
| format | Article |
| id | doaj.art-d22bc4325a964b449b24b7138dba238b |
| institution | Directory Open Access Journal |
| issn | 2226-4787 |
| language | English |
| last_indexed | 2024-03-09T03:57:57Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmacy |
| spelling | doaj.art-d22bc4325a964b449b24b7138dba238b2023-12-03T14:18:21ZengMDPI AGPharmacy2226-47872022-07-011048710.3390/pharmacy10040087Adherence to and Persistence with Adalimumab Therapy among Swedish Patients with Crohn’s DiseaseYifei Liu0Joakim Söderberg1Jingdong Chao2Division of Pharmacy Practice and Administration, The University of Missouri–Kansas City School of Pharmacy, Kansas City, MO 64108, USAHealth Solutions, 118 26 Stockholm, SwedenRegeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USAObjectives: (1) to determine the adherence and persistence rates of adalimumab therapy among Swedish patients with Crohn’s disease (CD), and (2) to compare self-administration devices to predict the medication adherence and persistence. Methods: We conducted a retrospective analysis of the Swedish National Board of Health and Welfare database during a unique time period, when both the pen and the syringe were available. The pen was proposed to indicate a larger extent of internal control, according to health locus of control. Medication adherence was defined as a medication possession ratio (MPR) ≥ 0.8. A patient was considered nonpersistent if the time between any two dispensing records, minus the days of supply dispensed exceeded 180 days. The predictors of adherence were evaluated using a logistic regression, and the predictors of persistence were evaluated using a Cox proportional hazards model. Results: Among the 1083 patients studied, 89% were adherent and 77% were persistent. The patients using the pen and the patients treated in gastroenterology centers were more likely to be adherent and less likely to be nonpersistent. Conclusions: The adherence rate to adalimumab therapy was 89% and the one-year persistence rate was 70%. The pen and treatment in a gastroenterology center had a positive impact on the adherence and persistence among Swedish patients with CD.https://www.mdpi.com/2226-4787/10/4/87medication adherencemedication persistencehealth locus of controladalimumab |
| spellingShingle | Yifei Liu Joakim Söderberg Jingdong Chao Adherence to and Persistence with Adalimumab Therapy among Swedish Patients with Crohn’s Disease Pharmacy medication adherence medication persistence health locus of control adalimumab |
| title | Adherence to and Persistence with Adalimumab Therapy among Swedish Patients with Crohn’s Disease |
| title_full | Adherence to and Persistence with Adalimumab Therapy among Swedish Patients with Crohn’s Disease |
| title_fullStr | Adherence to and Persistence with Adalimumab Therapy among Swedish Patients with Crohn’s Disease |
| title_full_unstemmed | Adherence to and Persistence with Adalimumab Therapy among Swedish Patients with Crohn’s Disease |
| title_short | Adherence to and Persistence with Adalimumab Therapy among Swedish Patients with Crohn’s Disease |
| title_sort | adherence to and persistence with adalimumab therapy among swedish patients with crohn s disease |
| topic | medication adherence medication persistence health locus of control adalimumab |
| url | https://www.mdpi.com/2226-4787/10/4/87 |
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