Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling
Immune cells contribute to adverse remodeling following myocardial infarction. Here the authors show in mice and pigs that CD8+ lymphocytes release Granzyme B in the infarcted heart leading to cardiomyocyte death, enhanced inflammation and deterioration of cardiac function.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21737-9 |
| _version_ | 1818435815396605952 |
|---|---|
| author | Icia Santos-Zas Jeremie Lemarié Ivana Zlatanova Marine Cachanado Jean-Christophe Seghezzi Hakim Benamer Pascal Goube Marie Vandestienne Raphael Cohen Maya Ezzo Vincent Duval Yujiao Zhang Jin-Bo Su Alain Bizé Lucien Sambin Philippe Bonnin Maxime Branchereau Christophe Heymes Corinne Tanchot José Vilar Clement Delacroix Jean-Sebastien Hulot Clement Cochain Patrick Bruneval Nicolas Danchin Alain Tedgui Ziad Mallat Tabassome Simon Bijan Ghaleh Jean-Sébastien Silvestre Hafid Ait-Oufella |
| author_facet | Icia Santos-Zas Jeremie Lemarié Ivana Zlatanova Marine Cachanado Jean-Christophe Seghezzi Hakim Benamer Pascal Goube Marie Vandestienne Raphael Cohen Maya Ezzo Vincent Duval Yujiao Zhang Jin-Bo Su Alain Bizé Lucien Sambin Philippe Bonnin Maxime Branchereau Christophe Heymes Corinne Tanchot José Vilar Clement Delacroix Jean-Sebastien Hulot Clement Cochain Patrick Bruneval Nicolas Danchin Alain Tedgui Ziad Mallat Tabassome Simon Bijan Ghaleh Jean-Sébastien Silvestre Hafid Ait-Oufella |
| author_sort | Icia Santos-Zas |
| collection | DOAJ |
| description | Immune cells contribute to adverse remodeling following myocardial infarction. Here the authors show in mice and pigs that CD8+ lymphocytes release Granzyme B in the infarcted heart leading to cardiomyocyte death, enhanced inflammation and deterioration of cardiac function. |
| first_indexed | 2024-12-14T16:58:53Z |
| format | Article |
| id | doaj.art-d22cf22ea4844f0bb37075c442f362fe |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T16:58:53Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d22cf22ea4844f0bb37075c442f362fe2022-12-21T22:53:53ZengNature PortfolioNature Communications2041-17232021-03-0112111310.1038/s41467-021-21737-9Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodelingIcia Santos-Zas0Jeremie Lemarié1Ivana Zlatanova2Marine Cachanado3Jean-Christophe Seghezzi4Hakim Benamer5Pascal Goube6Marie Vandestienne7Raphael Cohen8Maya Ezzo9Vincent Duval10Yujiao Zhang11Jin-Bo Su12Alain Bizé13Lucien Sambin14Philippe Bonnin15Maxime Branchereau16Christophe Heymes17Corinne Tanchot18José Vilar19Clement Delacroix20Jean-Sebastien Hulot21Clement Cochain22Patrick Bruneval23Nicolas Danchin24Alain Tedgui25Ziad Mallat26Tabassome Simon27Bijan Ghaleh28Jean-Sébastien Silvestre29Hafid Ait-Oufella30Université de Paris, PARCC, INSERMUniversité de Paris, PARCC, INSERMUniversité de Paris, PARCC, INSERMAssistance Publique-Hôpitaux de Paris, APHP.SU; Department of Clinical Pharmacology and Clinical Research Platform (URCEST-CRB-CRC-EST), Hôpital Saint AntoineService de cardiologie, Centre Hospitalier de CompiegneService de cardiologie, Institut Cardiovasculaire Paris SudService de cardiologie, Centre Hospitalier de CorbeilUniversité de Paris, PARCC, INSERMUniversité de Paris, PARCC, INSERMUniversité de Paris, PARCC, INSERMUniversité de Paris, PARCC, INSERMUniversité de Paris, PARCC, INSERMInserm U955-IMRB, Equipe 03, UPEC, Ecole Nationale Vétérinaire d’AlfortInserm U955-IMRB, Equipe 03, UPEC, Ecole Nationale Vétérinaire d’AlfortInserm U955-IMRB, Equipe 03, UPEC, Ecole Nationale Vétérinaire d’AlfortInserm U965, Department of Physiology, Assistance Publique Hôpitaux de ParisInserm U1048-Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), université Paul SabatierInserm U1048-Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), université Paul SabatierUniversité de Paris, PARCC, INSERMUniversité de Paris, PARCC, INSERMUniversité de Paris, PARCC, INSERMUniversité de Paris, PARCC, INSERMInstitute of Experimental Biomedicine, University Hospital WürzburgUniversité de Paris, PARCC, INSERMService de cardiologie, Hôpital Europeen G. Pompidou, Assistance Publique, Hôpitaux de ParisUniversité de Paris, PARCC, INSERMUniversité de Paris, PARCC, INSERMAssistance Publique-Hôpitaux de Paris, APHP.SU; Department of Clinical Pharmacology and Clinical Research Platform (URCEST-CRB-CRC-EST), Hôpital Saint AntoineInserm U955-IMRB, Equipe 03, UPEC, Ecole Nationale Vétérinaire d’AlfortUniversité de Paris, PARCC, INSERMUniversité de Paris, PARCC, INSERMImmune cells contribute to adverse remodeling following myocardial infarction. Here the authors show in mice and pigs that CD8+ lymphocytes release Granzyme B in the infarcted heart leading to cardiomyocyte death, enhanced inflammation and deterioration of cardiac function.https://doi.org/10.1038/s41467-021-21737-9 |
| spellingShingle | Icia Santos-Zas Jeremie Lemarié Ivana Zlatanova Marine Cachanado Jean-Christophe Seghezzi Hakim Benamer Pascal Goube Marie Vandestienne Raphael Cohen Maya Ezzo Vincent Duval Yujiao Zhang Jin-Bo Su Alain Bizé Lucien Sambin Philippe Bonnin Maxime Branchereau Christophe Heymes Corinne Tanchot José Vilar Clement Delacroix Jean-Sebastien Hulot Clement Cochain Patrick Bruneval Nicolas Danchin Alain Tedgui Ziad Mallat Tabassome Simon Bijan Ghaleh Jean-Sébastien Silvestre Hafid Ait-Oufella Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling Nature Communications |
| title | Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling |
| title_full | Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling |
| title_fullStr | Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling |
| title_full_unstemmed | Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling |
| title_short | Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling |
| title_sort | cytotoxic cd8 t cells promote granzyme b dependent adverse post ischemic cardiac remodeling |
| url | https://doi.org/10.1038/s41467-021-21737-9 |
| work_keys_str_mv | AT iciasantoszas cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT jeremielemarie cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT ivanazlatanova cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT marinecachanado cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT jeanchristopheseghezzi cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT hakimbenamer cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT pascalgoube cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT marievandestienne cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT raphaelcohen cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT mayaezzo cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT vincentduval cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT yujiaozhang cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT jinbosu cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT alainbize cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT luciensambin cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT philippebonnin cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT maximebranchereau cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT christopheheymes cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT corinnetanchot cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT josevilar cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT clementdelacroix cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT jeansebastienhulot cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT clementcochain cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT patrickbruneval cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT nicolasdanchin cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT alaintedgui cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT ziadmallat cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT tabassomesimon cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT bijanghaleh cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT jeansebastiensilvestre cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling AT hafidaitoufella cytotoxiccd8tcellspromotegranzymebdependentadversepostischemiccardiacremodeling |