Interleukin-27 and Its Diverse Effects on Bacterial Infections
Innate and adaptive immune responses against pathogens are known to be carefully orchestrated by specific cytokines that initiate and down regulate immune cell functions from the initial infection through tissue repair and homeostasis. However, some cytokines, including interleukin-27, are expressed...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-05-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.678515/full |
| _version_ | 1819042085950455808 |
|---|---|
| author | Yugo Morita Yugo Morita Elysia A. Masters Elysia A. Masters Edward M. Schwarz Edward M. Schwarz Edward M. Schwarz Gowrishankar Muthukrishnan Gowrishankar Muthukrishnan |
| author_facet | Yugo Morita Yugo Morita Elysia A. Masters Elysia A. Masters Edward M. Schwarz Edward M. Schwarz Edward M. Schwarz Gowrishankar Muthukrishnan Gowrishankar Muthukrishnan |
| author_sort | Yugo Morita |
| collection | DOAJ |
| description | Innate and adaptive immune responses against pathogens are known to be carefully orchestrated by specific cytokines that initiate and down regulate immune cell functions from the initial infection through tissue repair and homeostasis. However, some cytokines, including interleukin-27, are expressed at multiple phases of the infection, such that their pro and anti-inflammatory functions have been difficult to interpret. As elucidation of specific cytokine functions throughout infection is central to our understanding of protective vs. susceptible immunity and return to homeostasis vs. prolonged inflammation leading to septic shock, here we review the literature on IL-27 signaling and the various functions of this heterodimeric ligand member of the IL-12 cytokine family. Canonically, IL-27 is produced by antigen-presenting cells, and is thought of as an immunostimulatory cytokine due to its capacity to induce Th1 differentiation. However, many studies have also identified various immunosuppressive effects of IL-27 signaling, including suppression of Th17 differentiation and induction of co-inhibitory receptors on T cells. Thus, the exact role of IL-27 in the context of infectious diseases remains a topic of debate and active research. Additionally, as recent interest has focused on clinical management of acute vs. chronic infections, and life-threatening “cytokine storm” from sepsis, we propose a hypothetical model to explain the biphasic role of IL-27 during the early and late phases of immune responses to reconcile its known pro and anti-inflammatory functions, which could be therapeutically regulated to improve patient outcomes of infection. |
| first_indexed | 2024-12-21T09:35:17Z |
| format | Article |
| id | doaj.art-d22d3a273b9740549ea86f4252201e7a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T09:35:17Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d22d3a273b9740549ea86f4252201e7a2022-12-21T19:08:39ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-05-011210.3389/fimmu.2021.678515678515Interleukin-27 and Its Diverse Effects on Bacterial InfectionsYugo Morita0Yugo Morita1Elysia A. Masters2Elysia A. Masters3Edward M. Schwarz4Edward M. Schwarz5Edward M. Schwarz6Gowrishankar Muthukrishnan7Gowrishankar Muthukrishnan8Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, United StatesDepartment of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, NY, United StatesCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, United StatesDepartment of Biomedical Engineering, University of Rochester Medical Center, Rochester, NY, United StatesCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, United StatesDepartment of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, NY, United StatesDepartment of Biomedical Engineering, University of Rochester Medical Center, Rochester, NY, United StatesCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, United StatesDepartment of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, NY, United StatesInnate and adaptive immune responses against pathogens are known to be carefully orchestrated by specific cytokines that initiate and down regulate immune cell functions from the initial infection through tissue repair and homeostasis. However, some cytokines, including interleukin-27, are expressed at multiple phases of the infection, such that their pro and anti-inflammatory functions have been difficult to interpret. As elucidation of specific cytokine functions throughout infection is central to our understanding of protective vs. susceptible immunity and return to homeostasis vs. prolonged inflammation leading to septic shock, here we review the literature on IL-27 signaling and the various functions of this heterodimeric ligand member of the IL-12 cytokine family. Canonically, IL-27 is produced by antigen-presenting cells, and is thought of as an immunostimulatory cytokine due to its capacity to induce Th1 differentiation. However, many studies have also identified various immunosuppressive effects of IL-27 signaling, including suppression of Th17 differentiation and induction of co-inhibitory receptors on T cells. Thus, the exact role of IL-27 in the context of infectious diseases remains a topic of debate and active research. Additionally, as recent interest has focused on clinical management of acute vs. chronic infections, and life-threatening “cytokine storm” from sepsis, we propose a hypothetical model to explain the biphasic role of IL-27 during the early and late phases of immune responses to reconcile its known pro and anti-inflammatory functions, which could be therapeutically regulated to improve patient outcomes of infection.https://www.frontiersin.org/articles/10.3389/fimmu.2021.678515/fullcytokine signalingbacteriasepsisbacterial infectionIL-27 cytokine |
| spellingShingle | Yugo Morita Yugo Morita Elysia A. Masters Elysia A. Masters Edward M. Schwarz Edward M. Schwarz Edward M. Schwarz Gowrishankar Muthukrishnan Gowrishankar Muthukrishnan Interleukin-27 and Its Diverse Effects on Bacterial Infections Frontiers in Immunology cytokine signaling bacteria sepsis bacterial infection IL-27 cytokine |
| title | Interleukin-27 and Its Diverse Effects on Bacterial Infections |
| title_full | Interleukin-27 and Its Diverse Effects on Bacterial Infections |
| title_fullStr | Interleukin-27 and Its Diverse Effects on Bacterial Infections |
| title_full_unstemmed | Interleukin-27 and Its Diverse Effects on Bacterial Infections |
| title_short | Interleukin-27 and Its Diverse Effects on Bacterial Infections |
| title_sort | interleukin 27 and its diverse effects on bacterial infections |
| topic | cytokine signaling bacteria sepsis bacterial infection IL-27 cytokine |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.678515/full |
| work_keys_str_mv | AT yugomorita interleukin27anditsdiverseeffectsonbacterialinfections AT yugomorita interleukin27anditsdiverseeffectsonbacterialinfections AT elysiaamasters interleukin27anditsdiverseeffectsonbacterialinfections AT elysiaamasters interleukin27anditsdiverseeffectsonbacterialinfections AT edwardmschwarz interleukin27anditsdiverseeffectsonbacterialinfections AT edwardmschwarz interleukin27anditsdiverseeffectsonbacterialinfections AT edwardmschwarz interleukin27anditsdiverseeffectsonbacterialinfections AT gowrishankarmuthukrishnan interleukin27anditsdiverseeffectsonbacterialinfections AT gowrishankarmuthukrishnan interleukin27anditsdiverseeffectsonbacterialinfections |