Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia

Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia

Abstract Background Mixed lineage leukemia (MLL) gene translocations are found in ~75 % infant and 10 % adult acute leukemia, showing a poor prognosis. Lysine-specific demethylase 1 (LSD1) has recently been implicated to be a drug target for this subtype of leukemia. More studies using potent LSD1 i...

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Bibliographic Details
Main Authors: Zizhen Feng, Yuan Yao, Chao Zhou, Fengju Chen, Fangrui Wu, Liping Wei, Wei Liu, Shuo Dong, Michele Redell, Qianxing Mo, Yongcheng Song
Format: Article
Language:English
Published: BMC 2016-03-01
Series:Journal of Hematology & Oncology
Subjects:
MLL-rearranged leukemia
Lysine-specific demethylase 1
Enzyme inhibitor
Drug discovery
Leukemia therapeutics
Online Access:http://link.springer.com/article/10.1186/s13045-016-0252-7

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