Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients
Abstract Background Chagas disease is caused by Trypanosoma cruzi, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fe...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2015-01-01
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| Series: | Parasites & Vectors |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13071-015-0632-9 |
| _version_ | 1797811916941295616 |
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| author | Jailson FB Querido María G Echeverría Gerardo A Marti Rita Medina Costa María L Susevich Jorge E Rabinovich Aydee Copa Nair A Montaño Lineth Garcia Marisol Cordova Faustino Torrico Rubén Sánchez-Eugenia Lissete Sánchez-Magraner Xabier Muñiz-Trabudua Ibai López-Marijuan Gabriela S Rozas-Dennis Patricio Diosque Ana M de Castro Carlos Robello Julio S Rodríguez Jaime Altcheh Paz M Salazar-Schettino Marta I Bucio Bertha Espinoza Diego MA Guérin Marcelo Sousa Silva |
| author_facet | Jailson FB Querido María G Echeverría Gerardo A Marti Rita Medina Costa María L Susevich Jorge E Rabinovich Aydee Copa Nair A Montaño Lineth Garcia Marisol Cordova Faustino Torrico Rubén Sánchez-Eugenia Lissete Sánchez-Magraner Xabier Muñiz-Trabudua Ibai López-Marijuan Gabriela S Rozas-Dennis Patricio Diosque Ana M de Castro Carlos Robello Julio S Rodríguez Jaime Altcheh Paz M Salazar-Schettino Marta I Bucio Bertha Espinoza Diego MA Guérin Marcelo Sousa Silva |
| author_sort | Jailson FB Querido |
| collection | DOAJ |
| description | Abstract Background Chagas disease is caused by Trypanosoma cruzi, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fecal-oral route and, as it happens with T. cruzi, the infected insects release the virus when defecating during or after blood uptake. Methods In this work, we analysed the occurrence of anti-TrV antibodies in human sera from Chagas disease endemic and non-endemic countries, and developed a mathematical model to estimate the transmission probability of TrV from insects to man, which ranged between 0.00053 and 0.0015. Results Our results confirm that people with Chagas disease living in Bolivia, Argentina and Mexico have been exposed to TrV, and that TrV is unable to replicate in human hosts. Conclusions We presented the first experimental evidence of antibodies against TrV structural proteins in human sera. |
| first_indexed | 2024-03-13T07:30:54Z |
| format | Article |
| id | doaj.art-d2308c1eaf9a470c857b19ff7b86d5fe |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-03-13T07:30:54Z |
| publishDate | 2015-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj.art-d2308c1eaf9a470c857b19ff7b86d5fe2023-06-04T11:08:23ZengBMCParasites & Vectors1756-33052015-01-01811910.1186/s13071-015-0632-9Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patientsJailson FB Querido0María G Echeverría1Gerardo A Marti2Rita Medina Costa3María L Susevich4Jorge E Rabinovich5Aydee Copa6Nair A Montaño7Lineth Garcia8Marisol Cordova9Faustino Torrico10Rubén Sánchez-Eugenia11Lissete Sánchez-Magraner12Xabier Muñiz-Trabudua13Ibai López-Marijuan14Gabriela S Rozas-Dennis15Patricio Diosque16Ana M de Castro17Carlos Robello18Julio S Rodríguez19Jaime Altcheh20Paz M Salazar-Schettino21Marta I Bucio22Bertha Espinoza23Diego MA Guérin24Marcelo Sousa Silva25Centre for Malaria and Tropical Diseases, Instituto de Higiene e Medicina Tropical, Universidade Nova de LisboaCátedra de Virología, Facultad de Ciencias Veterinarias Universidad Nacional de La Plata (UNLP-CONICET)Centro de Estudios Parasitológicos y de Vectores (CEPAVE-CCT- La Plata -CONICET - UNLP)Centre for Malaria and Tropical Diseases, Instituto de Higiene e Medicina Tropical, Universidade Nova de LisboaCátedra de Virología, Facultad de Ciencias Veterinarias Universidad Nacional de La Plata (UNLP-CONICET)Centro de Estudios Parasitológicos y de Vectores (CEPAVE-CCT- La Plata -CONICET - UNLP)Laboratorio de Biología Molecular IIBISMED, Facultad de Medicina, Universidad Mayor de San SimónLaboratorio de Biología Molecular IIBISMED, Facultad de Medicina, Universidad Mayor de San SimónLaboratorio de Biología Molecular IIBISMED, Facultad de Medicina, Universidad Mayor de San SimónFacultad de Medicina, Universidad Mayor de San SimónFacultad de Medicina, Universidad Mayor de San SimónUnidad de Biofísica (UBF, CSIC, UPV-EHU)Unidad de Biofísica (UBF, CSIC, UPV-EHU)Unidad de Biofísica (UBF, CSIC, UPV-EHU)Unidad de Biofísica (UBF, CSIC, UPV-EHU)Departamento de Biología, Bioquímica y Farmacia, and Grupo Biofísica, Departamento de Física, Universidad Nacional del SurUnidad de Epidemiología Molecular del Instituto de Patología Experimental, Facultad de Ciencias de la Salud, Universidad Nacional de SaltaInstituto de Patologia Tropical e Saúde Pública, Universidade Federal de GoiásUnidad de Biología Molecular Instituto Pasteur de MontevideoCENPALAB, Delegación CIMTAParasitologia-Chagas, Hospital de Niños R. GutierrezDepartamento de Microbiología y Parasitología, Facultad de Medicina (LBP-DMP-FM), Universidad Nacional Autónoma de MéxicoDepartamento de Microbiología y Parasitología, Facultad de Medicina (LBP-DMP-FM), Universidad Nacional Autónoma de MéxicoDepartamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Autónoma de MéxicoUnidad de Biofísica (UBF, CSIC, UPV-EHU)Centre for Malaria and Tropical Diseases, Instituto de Higiene e Medicina Tropical, Universidade Nova de LisboaAbstract Background Chagas disease is caused by Trypanosoma cruzi, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fecal-oral route and, as it happens with T. cruzi, the infected insects release the virus when defecating during or after blood uptake. Methods In this work, we analysed the occurrence of anti-TrV antibodies in human sera from Chagas disease endemic and non-endemic countries, and developed a mathematical model to estimate the transmission probability of TrV from insects to man, which ranged between 0.00053 and 0.0015. Results Our results confirm that people with Chagas disease living in Bolivia, Argentina and Mexico have been exposed to TrV, and that TrV is unable to replicate in human hosts. Conclusions We presented the first experimental evidence of antibodies against TrV structural proteins in human sera.https://doi.org/10.1186/s13071-015-0632-9Triatoma virusDicistroviridaeTrypanosoma cruziTriatominesChagas diseaseMathematical model |
| spellingShingle | Jailson FB Querido María G Echeverría Gerardo A Marti Rita Medina Costa María L Susevich Jorge E Rabinovich Aydee Copa Nair A Montaño Lineth Garcia Marisol Cordova Faustino Torrico Rubén Sánchez-Eugenia Lissete Sánchez-Magraner Xabier Muñiz-Trabudua Ibai López-Marijuan Gabriela S Rozas-Dennis Patricio Diosque Ana M de Castro Carlos Robello Julio S Rodríguez Jaime Altcheh Paz M Salazar-Schettino Marta I Bucio Bertha Espinoza Diego MA Guérin Marcelo Sousa Silva Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients Parasites & Vectors Triatoma virus Dicistroviridae Trypanosoma cruzi Triatomines Chagas disease Mathematical model |
| title | Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients |
| title_full | Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients |
| title_fullStr | Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients |
| title_full_unstemmed | Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients |
| title_short | Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients |
| title_sort | seroprevalence of triatoma virus dicistroviridae cripaviridae antibodies in chagas disease patients |
| topic | Triatoma virus Dicistroviridae Trypanosoma cruzi Triatomines Chagas disease Mathematical model |
| url | https://doi.org/10.1186/s13071-015-0632-9 |
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