Enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposure
Methamphetamine (MA) consumption causes disruption of many biological rhythms including the sleep-wake cycle. This circadian effect is seen shortly following MA exposure and later in life following developmental MA exposure. MA phase shifts, entrains the circadian clock and can also alter the entrai...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-09-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00326/full |
| _version_ | 1819129878997368832 |
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| author | Damian Gabriel Zuloaga Ovidiu eIancu Sydney eWeber Desiree eEtzel Tessa eMarzulla Blair eStewart Charles N. Allen Jacob eRaber |
| author_facet | Damian Gabriel Zuloaga Ovidiu eIancu Sydney eWeber Desiree eEtzel Tessa eMarzulla Blair eStewart Charles N. Allen Jacob eRaber |
| author_sort | Damian Gabriel Zuloaga |
| collection | DOAJ |
| description | Methamphetamine (MA) consumption causes disruption of many biological rhythms including the sleep-wake cycle. This circadian effect is seen shortly following MA exposure and later in life following developmental MA exposure. MA phase shifts, entrains the circadian clock and can also alter the entraining effect of light by currently unknown mechanisms. We analyzed and compared immunoreactivity of the immediate early gene c-Fos, a marker of neuronal activity, to assess neuronal activation two hours following MA exposure in the light and dark phases. We used network analyses of correlation patterns derived from global brain immunoreactivity patterns of c-Fos, to infer functional connectivity between brain regions. There were five distinct patterns of neuronal activation. In several brain areas, neuronal activation following exposure to MA was stronger in the light than the dark phase, highlighting the importance of considering circadian periods of increased sensitivity to MA in defining experimental conditions and understanding the mechanisms underlying detrimental effects of MA exposure to brain function. Functional connectivity between the ventromedial hypothalamus (VMH) and other brain areas, including the paraventricular nucleus of the hypothalamus and basolateral and medial amygdala, was enhanced following MA exposure, suggesting a role for the VMH in the effects of methamphetamine on the brain. |
| first_indexed | 2024-12-22T08:50:43Z |
| format | Article |
| id | doaj.art-d231f04daae844928c223666dc407469 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-22T08:50:43Z |
| publishDate | 2015-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-d231f04daae844928c223666dc4074692022-12-21T18:31:59ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2015-09-01910.3389/fnins.2015.00326162611Enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposureDamian Gabriel Zuloaga0Ovidiu eIancu1Sydney eWeber2Desiree eEtzel3Tessa eMarzulla4Blair eStewart5Charles N. Allen6Jacob eRaber7OHSUOHSUOHSUOHSUOHSUOHSUOHSUOHSUMethamphetamine (MA) consumption causes disruption of many biological rhythms including the sleep-wake cycle. This circadian effect is seen shortly following MA exposure and later in life following developmental MA exposure. MA phase shifts, entrains the circadian clock and can also alter the entraining effect of light by currently unknown mechanisms. We analyzed and compared immunoreactivity of the immediate early gene c-Fos, a marker of neuronal activity, to assess neuronal activation two hours following MA exposure in the light and dark phases. We used network analyses of correlation patterns derived from global brain immunoreactivity patterns of c-Fos, to infer functional connectivity between brain regions. There were five distinct patterns of neuronal activation. In several brain areas, neuronal activation following exposure to MA was stronger in the light than the dark phase, highlighting the importance of considering circadian periods of increased sensitivity to MA in defining experimental conditions and understanding the mechanisms underlying detrimental effects of MA exposure to brain function. Functional connectivity between the ventromedial hypothalamus (VMH) and other brain areas, including the paraventricular nucleus of the hypothalamus and basolateral and medial amygdala, was enhanced following MA exposure, suggesting a role for the VMH in the effects of methamphetamine on the brain.http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00326/fullCircadian RhythmMethamphetaminecfosventromedial hypothalamusnetwork connectivity analysis |
| spellingShingle | Damian Gabriel Zuloaga Ovidiu eIancu Sydney eWeber Desiree eEtzel Tessa eMarzulla Blair eStewart Charles N. Allen Jacob eRaber Enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposure Frontiers in Neuroscience Circadian Rhythm Methamphetamine cfos ventromedial hypothalamus network connectivity analysis |
| title | Enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposure |
| title_full | Enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposure |
| title_fullStr | Enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposure |
| title_full_unstemmed | Enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposure |
| title_short | Enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposure |
| title_sort | enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposure |
| topic | Circadian Rhythm Methamphetamine cfos ventromedial hypothalamus network connectivity analysis |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00326/full |
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