Resolving multisensory and attentional influences across cortical depth in sensory cortices
In our environment, our senses are bombarded with a myriad of signals, only a subset of which is relevant for our goals. Using sub-millimeter-resolution fMRI at 7T, we resolved BOLD-response and activation patterns across cortical depth in early sensory cortices to auditory, visual and audiovisual s...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-01-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/46856 |
| _version_ | 1818027095015555072 |
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| author | Remi Gau Pierre-Louis Bazin Robert Trampel Robert Turner Uta Noppeney |
| author_facet | Remi Gau Pierre-Louis Bazin Robert Trampel Robert Turner Uta Noppeney |
| author_sort | Remi Gau |
| collection | DOAJ |
| description | In our environment, our senses are bombarded with a myriad of signals, only a subset of which is relevant for our goals. Using sub-millimeter-resolution fMRI at 7T, we resolved BOLD-response and activation patterns across cortical depth in early sensory cortices to auditory, visual and audiovisual stimuli under auditory or visual attention. In visual cortices, auditory stimulation induced widespread inhibition irrespective of attention, whereas auditory relative to visual attention suppressed mainly central visual field representations. In auditory cortices, visual stimulation suppressed activations, but amplified responses to concurrent auditory stimuli, in a patchy topography. Critically, multisensory interactions in auditory cortices were stronger in deeper laminae, while attentional influences were greatest at the surface. These distinct depth-dependent profiles suggest that multisensory and attentional mechanisms regulate sensory processing via partly distinct circuitries. Our findings are crucial for understanding how the brain regulates information flow across senses to interact with our complex multisensory world. |
| first_indexed | 2024-12-10T04:42:27Z |
| format | Article |
| id | doaj.art-d23640f0524946d08c6d041c85d01b21 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-12-10T04:42:27Z |
| publishDate | 2020-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-d23640f0524946d08c6d041c85d01b212022-12-22T02:01:51ZengeLife Sciences Publications LtdeLife2050-084X2020-01-01910.7554/eLife.46856Resolving multisensory and attentional influences across cortical depth in sensory corticesRemi Gau0https://orcid.org/0000-0002-1535-9767Pierre-Louis Bazin1https://orcid.org/0000-0002-0141-5510Robert Trampel2Robert Turner3Uta Noppeney4Computational Neuroscience and Cognitive Robotics Centre, University of Birmingham, Birmingham, United Kingdom; Institute of Psychology, Université Catholique de Louvain, Louvain-la-Neuve, Belgium; Institute of Neuroscience, Université Catholique de Louvain, Louvain-la-Neuve, BelgiumMax Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Integrative Model-based Cognitive Neuroscience research unit, University of Amsterdam, Amsterdam, NetherlandsMax Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyMax Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United KingdomComputational Neuroscience and Cognitive Robotics Centre, University of Birmingham, Birmingham, United Kingdom; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, NetherlandsIn our environment, our senses are bombarded with a myriad of signals, only a subset of which is relevant for our goals. Using sub-millimeter-resolution fMRI at 7T, we resolved BOLD-response and activation patterns across cortical depth in early sensory cortices to auditory, visual and audiovisual stimuli under auditory or visual attention. In visual cortices, auditory stimulation induced widespread inhibition irrespective of attention, whereas auditory relative to visual attention suppressed mainly central visual field representations. In auditory cortices, visual stimulation suppressed activations, but amplified responses to concurrent auditory stimuli, in a patchy topography. Critically, multisensory interactions in auditory cortices were stronger in deeper laminae, while attentional influences were greatest at the surface. These distinct depth-dependent profiles suggest that multisensory and attentional mechanisms regulate sensory processing via partly distinct circuitries. Our findings are crucial for understanding how the brain regulates information flow across senses to interact with our complex multisensory world.https://elifesciences.org/articles/46856multisensory integrationaudiovisualprimary sensory corticesdeactivations,crossmodal attentioncortical layers |
| spellingShingle | Remi Gau Pierre-Louis Bazin Robert Trampel Robert Turner Uta Noppeney Resolving multisensory and attentional influences across cortical depth in sensory cortices eLife multisensory integration audiovisual primary sensory cortices deactivations, crossmodal attention cortical layers |
| title | Resolving multisensory and attentional influences across cortical depth in sensory cortices |
| title_full | Resolving multisensory and attentional influences across cortical depth in sensory cortices |
| title_fullStr | Resolving multisensory and attentional influences across cortical depth in sensory cortices |
| title_full_unstemmed | Resolving multisensory and attentional influences across cortical depth in sensory cortices |
| title_short | Resolving multisensory and attentional influences across cortical depth in sensory cortices |
| title_sort | resolving multisensory and attentional influences across cortical depth in sensory cortices |
| topic | multisensory integration audiovisual primary sensory cortices deactivations, crossmodal attention cortical layers |
| url | https://elifesciences.org/articles/46856 |
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