The functions of CD4 T-helper lymphocytes in chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) has been increasingly accounted for global morbidity and mortality worldwide. Although it is partially reversible, the obstructive ventilatory schema of COPD often causes chronic inflammation that primarily affects peripheral airways, pulmonary parenchyma...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2021-12-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2021009 |
| _version_ | 1797635846534332416 |
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| author | Qin Keru Xu Baixue Pang Min Wang Hailong Yu Baofeng |
| author_facet | Qin Keru Xu Baixue Pang Min Wang Hailong Yu Baofeng |
| author_sort | Qin Keru |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) has been increasingly accounted for global morbidity and mortality worldwide. Although it is partially reversible, the obstructive ventilatory schema of COPD often causes chronic inflammation that primarily affects peripheral airways, pulmonary parenchyma, and the development of lung lymphoid follicles. Among various T-helper (Th) cell types associated with COPD, Th1, Th2 and Th17 cell numbers are increased in COPD patients, whereas Treg cell number is reduced. Here, we reviewed recent advance in understanding the roles of Th1/Th2 and Th17/Treg in the pathogenesis of COPD and discussed the potential underlying mechanism. |
| first_indexed | 2024-03-11T12:26:07Z |
| format | Article |
| id | doaj.art-d239ee904ce04602b724b6a892c69c0f |
| institution | Directory Open Access Journal |
| issn | 1672-9145 |
| language | English |
| last_indexed | 2024-03-11T12:26:07Z |
| publishDate | 2021-12-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj.art-d239ee904ce04602b724b6a892c69c0f2023-11-06T09:02:42ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452021-12-015417317810.3724/abbs.202100920d259ccThe functions of CD4 T-helper lymphocytes in chronic obstructive pulmonary diseaseQin Keru0Xu Baixue1Pang Min2Wang Hailong3Yu Baofeng4["Department of Biochemistry and Molecular Biology, School of Basic Medicine, Basic Medical Science Center, Shanxi Medical University, Jinzhong 030600, China"]["Department of Biochemistry and Molecular Biology, School of Basic Medicine, Basic Medical Science Center, Shanxi Medical University, Jinzhong 030600, China"]["Department of Pulmonary and Critical Care Medicine, the First Hospital, Shanxi Medical University, Taiyuan 030001, China"]["Department of Biochemistry and Molecular Biology, School of Basic Medicine, Basic Medical Science Center, Shanxi Medical University, Jinzhong 030600, China"]["Department of Biochemistry and Molecular Biology, School of Basic Medicine, Basic Medical Science Center, Shanxi Medical University, Jinzhong 030600, China"]Chronic obstructive pulmonary disease (COPD) has been increasingly accounted for global morbidity and mortality worldwide. Although it is partially reversible, the obstructive ventilatory schema of COPD often causes chronic inflammation that primarily affects peripheral airways, pulmonary parenchyma, and the development of lung lymphoid follicles. Among various T-helper (Th) cell types associated with COPD, Th1, Th2 and Th17 cell numbers are increased in COPD patients, whereas Treg cell number is reduced. Here, we reviewed recent advance in understanding the roles of Th1/Th2 and Th17/Treg in the pathogenesis of COPD and discussed the potential underlying mechanism.https://www.sciengine.com/doi/10.3724/abbs.2021009lymphocytechronic obstructive pulmonary diseaseinflammation |
| spellingShingle | Qin Keru Xu Baixue Pang Min Wang Hailong Yu Baofeng The functions of CD4 T-helper lymphocytes in chronic obstructive pulmonary disease Acta Biochimica et Biophysica Sinica lymphocyte chronic obstructive pulmonary disease inflammation |
| title | The functions of CD4 T-helper lymphocytes in chronic obstructive pulmonary disease |
| title_full | The functions of CD4 T-helper lymphocytes in chronic obstructive pulmonary disease |
| title_fullStr | The functions of CD4 T-helper lymphocytes in chronic obstructive pulmonary disease |
| title_full_unstemmed | The functions of CD4 T-helper lymphocytes in chronic obstructive pulmonary disease |
| title_short | The functions of CD4 T-helper lymphocytes in chronic obstructive pulmonary disease |
| title_sort | functions of cd4 t helper lymphocytes in chronic obstructive pulmonary disease |
| topic | lymphocyte chronic obstructive pulmonary disease inflammation |
| url | https://www.sciengine.com/doi/10.3724/abbs.2021009 |
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