Circadian Functioning and Quality of Life in Substance Use Disorder Patients With and Without Comorbid Major Depressive Disorder
Aim: Although a relationship between circadian disruption and development of several psychiatric disorders, such as major depressive disorder (MDD) and substance use disorder (SUD), has been observed, knowledge on this area is scarce yet. Therefore, this study aims to analyze the circadian functioni...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.750500/full |
| _version_ | 1819143753806381056 |
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| author | Iman Hashemzadeh Julia E. Marquez-Arrico Kosar Hashemzadeh José Francisco Navarro Ana Adan Ana Adan |
| author_facet | Iman Hashemzadeh Julia E. Marquez-Arrico Kosar Hashemzadeh José Francisco Navarro Ana Adan Ana Adan |
| author_sort | Iman Hashemzadeh |
| collection | DOAJ |
| description | Aim: Although a relationship between circadian disruption and development of several psychiatric disorders, such as major depressive disorder (MDD) and substance use disorder (SUD), has been observed, knowledge on this area is scarce yet. Therefore, this study aims to analyze the circadian functioning and quality of life (QOL) in SUD patients with and without comorbid MDD, two highly prevalent clinical entities with difficult therapeutic management.Methods: One hundred sixty-three male patients under treatment, 81 with SUD and 82 with SUD comorbid major depressive disorder (SUD + MDD), were evaluated. For the circadian functioning assessment, we calculated Social Jet Lag (SJL) and used the reduced Morningness–Eveningness Questionnaire (rMEQ) and the Pittsburgh Sleep Quality Index (PSQI). QOL was measured using the shortened version of the World Health Organization's Quality of Life Questionnaire (WHOQOL-BREF). We collected sociodemographic and clinical variables to evaluate their possible influence on the circadian functioning. Intergroup differences among the variables were examined by different analyses of covariance (ANCOVA and MANCOVA). The possible relationships of quantitative clinical variables with rMEQ, PSQI, and WHOQOL-BREF were explored using bivariate correlation analysis.Results: Lower SJL appears in the SUD + MDD group compared with SUD. The intermediate-type was more prevalent in the SUD group, while a higher percentage of morning-type patients was found in the SUD + MDD. Sleep quality (including latency and daytime dysfunction) was worse for SUD + MDD patients than for SUD even after controlling age and age of SUD onset variables. Last, QOL was poorer in patients with SUD + MDD and, for them, psychological health had a negative relationship with SJL and severity of depression.Conclusions: Our data support and extend previous findings indicating that SUD + MDD is associated with worse clinical characteristics, more sleep problems, and poorer QOL than SUD patients. These results underline the importance of a precise assessment of these measurements in future studies conducted in SUD patients with/without MDD comorbidity that could be considered from a therapeutic point of view. |
| first_indexed | 2024-12-22T12:31:15Z |
| format | Article |
| id | doaj.art-d23d32998a4146338481a83e71fb5bdc |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-22T12:31:15Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-d23d32998a4146338481a83e71fb5bdc2022-12-21T18:25:39ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-10-011210.3389/fpsyt.2021.750500750500Circadian Functioning and Quality of Life in Substance Use Disorder Patients With and Without Comorbid Major Depressive DisorderIman Hashemzadeh0Julia E. Marquez-Arrico1Kosar Hashemzadeh2José Francisco Navarro3Ana Adan4Ana Adan5Department of Clinical Psychology and Psychobiology, School of Psychology, University of Barcelona, Barcelona, SpainDepartment of Clinical Psychology and Psychobiology, School of Psychology, University of Barcelona, Barcelona, SpainDepartment of Psychology, Fasa Branch, Islamic Azad University, Fasa, IranDepartment of Psychobiology, School of Psychology, University of Málaga, Málaga, SpainDepartment of Clinical Psychology and Psychobiology, School of Psychology, University of Barcelona, Barcelona, SpainInstitute of Neurosciences, University of Barcelona, Barcelona, SpainAim: Although a relationship between circadian disruption and development of several psychiatric disorders, such as major depressive disorder (MDD) and substance use disorder (SUD), has been observed, knowledge on this area is scarce yet. Therefore, this study aims to analyze the circadian functioning and quality of life (QOL) in SUD patients with and without comorbid MDD, two highly prevalent clinical entities with difficult therapeutic management.Methods: One hundred sixty-three male patients under treatment, 81 with SUD and 82 with SUD comorbid major depressive disorder (SUD + MDD), were evaluated. For the circadian functioning assessment, we calculated Social Jet Lag (SJL) and used the reduced Morningness–Eveningness Questionnaire (rMEQ) and the Pittsburgh Sleep Quality Index (PSQI). QOL was measured using the shortened version of the World Health Organization's Quality of Life Questionnaire (WHOQOL-BREF). We collected sociodemographic and clinical variables to evaluate their possible influence on the circadian functioning. Intergroup differences among the variables were examined by different analyses of covariance (ANCOVA and MANCOVA). The possible relationships of quantitative clinical variables with rMEQ, PSQI, and WHOQOL-BREF were explored using bivariate correlation analysis.Results: Lower SJL appears in the SUD + MDD group compared with SUD. The intermediate-type was more prevalent in the SUD group, while a higher percentage of morning-type patients was found in the SUD + MDD. Sleep quality (including latency and daytime dysfunction) was worse for SUD + MDD patients than for SUD even after controlling age and age of SUD onset variables. Last, QOL was poorer in patients with SUD + MDD and, for them, psychological health had a negative relationship with SJL and severity of depression.Conclusions: Our data support and extend previous findings indicating that SUD + MDD is associated with worse clinical characteristics, more sleep problems, and poorer QOL than SUD patients. These results underline the importance of a precise assessment of these measurements in future studies conducted in SUD patients with/without MDD comorbidity that could be considered from a therapeutic point of view.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.750500/fullsubstance use disordermajor depressive disorderdual disorderquality of lifecircadian rhythmsleep quality |
| spellingShingle | Iman Hashemzadeh Julia E. Marquez-Arrico Kosar Hashemzadeh José Francisco Navarro Ana Adan Ana Adan Circadian Functioning and Quality of Life in Substance Use Disorder Patients With and Without Comorbid Major Depressive Disorder Frontiers in Psychiatry substance use disorder major depressive disorder dual disorder quality of life circadian rhythm sleep quality |
| title | Circadian Functioning and Quality of Life in Substance Use Disorder Patients With and Without Comorbid Major Depressive Disorder |
| title_full | Circadian Functioning and Quality of Life in Substance Use Disorder Patients With and Without Comorbid Major Depressive Disorder |
| title_fullStr | Circadian Functioning and Quality of Life in Substance Use Disorder Patients With and Without Comorbid Major Depressive Disorder |
| title_full_unstemmed | Circadian Functioning and Quality of Life in Substance Use Disorder Patients With and Without Comorbid Major Depressive Disorder |
| title_short | Circadian Functioning and Quality of Life in Substance Use Disorder Patients With and Without Comorbid Major Depressive Disorder |
| title_sort | circadian functioning and quality of life in substance use disorder patients with and without comorbid major depressive disorder |
| topic | substance use disorder major depressive disorder dual disorder quality of life circadian rhythm sleep quality |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.750500/full |
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