Biological Activities of <i>Sargassum</i> Algae Mediated ZnO and Co Doped ZnO Nanoparticles as Enhanced Antioxidant and Anti-Diabetic Agents
Brown macroalgae (BMG) were used as carriers for ZnO (ZnO/BMG) and cobalt-doped ZnO (Co-ZnO/BMG) via facile microwave-assisted hydrothermal synthesis. The multifunctional structures of synthesized composites were evaluated as enhanced antioxidant and anti-diabetic agents based on the synergistic eff...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/9/3692 |
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| author | Hassan Ahmed Rudayni Abdelrahman M. Rabie Malak Aladwani Lina M. Alneghery Gasem M. Abu-Taweel Wail Al Zoubi Ahmed A. Allam Mostafa R. Abukhadra Stefano Bellucci |
| author_facet | Hassan Ahmed Rudayni Abdelrahman M. Rabie Malak Aladwani Lina M. Alneghery Gasem M. Abu-Taweel Wail Al Zoubi Ahmed A. Allam Mostafa R. Abukhadra Stefano Bellucci |
| author_sort | Hassan Ahmed Rudayni |
| collection | DOAJ |
| description | Brown macroalgae (BMG) were used as carriers for ZnO (ZnO/BMG) and cobalt-doped ZnO (Co-ZnO/BMG) via facile microwave-assisted hydrothermal synthesis. The multifunctional structures of synthesized composites were evaluated as enhanced antioxidant and anti-diabetic agents based on the synergistic effects of ZnO, Co-ZnO, and BMG. BMG substrate incorporation and cobalt doping notably enhanced the bioactivity of the synthesized ZnO nanoparticles. As an antioxidant, the Co-ZnO/BMG composite exhibited highly effective scavenging properties for the common free reactive oxygen radicals (DPPH [89.6 ± 1.5%], nitric oxide [90.2 ± 1.3%], ABTS [87.7 ± 1.8%], and O<sub>2</sub><sup>●−</sup> [46.7 ± 1.9%]) as compared to ascorbic acid. Additionally, its anti-diabetic activity was enhanced significantly and strongly inhibited essential oxidative enzymes (porcine α-amylase (90.6 ± 1.5%), crude α-amylase (84.3 ± 1.8%), pancreatic α-glucosidase (95.7 ± 1.4%), crude intestinal α-glucosidase (93.4 ± 1.8%), and amyloglucosidase (96.2 ± 1.4%)). Co-ZnO/BMG inhibitory activity was higher than that of miglitol, and in some cases, higher than or close to that of acarbose. Therefore, the synthetic Co-ZnO/BMG composite can be used as a commercial anti-diabetic and antioxidant agent, considering the cost and adverse side effects of current drugs. The results also demonstrate the impact of cobalt doping and BMG integration on the biological activity of ZnO. |
| first_indexed | 2024-03-11T04:12:32Z |
| format | Article |
| id | doaj.art-d23eb16169ad4dd2b1c12e8a97b4f8c9 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T04:12:32Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d23eb16169ad4dd2b1c12e8a97b4f8c92023-11-17T23:22:10ZengMDPI AGMolecules1420-30492023-04-01289369210.3390/molecules28093692Biological Activities of <i>Sargassum</i> Algae Mediated ZnO and Co Doped ZnO Nanoparticles as Enhanced Antioxidant and Anti-Diabetic AgentsHassan Ahmed Rudayni0Abdelrahman M. Rabie1Malak Aladwani2Lina M. Alneghery3Gasem M. Abu-Taweel4Wail Al Zoubi5Ahmed A. Allam6Mostafa R. Abukhadra7Stefano Bellucci8Department of Biology, College of Science, Imam Muhammad bin Saud Islamic University, Riyadh 11623, Saudi ArabiaPetrochemicals Department, Egyptian Petroleum Research Institute, Nasr City, Cairo 11727, EgyptDepartment of Biology, College of Science, Imam Muhammad bin Saud Islamic University, Riyadh 11623, Saudi ArabiaDepartment of Biology, College of Science, Imam Muhammad bin Saud Islamic University, Riyadh 11623, Saudi ArabiaDepartment of Biology, College of Science, Jazan University, P.O. Box 2079, Jazan 45142, Saudi ArabiaMaterials Electrochemistry Laboratory, School of Materials Science and Engineering, Yeungnam University, Gyeongsan 38541, Republic of KoreaZoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 65214, EgyptMaterials Technologies and Their Applications Lab, Geology Department, Faculty of Science, Beni-Suef University, Beni-Suef 65214, EgyptINFN, Laboratori Nazionali di Frascati, E. Fermi 54, 00044 Frascati, ItalyBrown macroalgae (BMG) were used as carriers for ZnO (ZnO/BMG) and cobalt-doped ZnO (Co-ZnO/BMG) via facile microwave-assisted hydrothermal synthesis. The multifunctional structures of synthesized composites were evaluated as enhanced antioxidant and anti-diabetic agents based on the synergistic effects of ZnO, Co-ZnO, and BMG. BMG substrate incorporation and cobalt doping notably enhanced the bioactivity of the synthesized ZnO nanoparticles. As an antioxidant, the Co-ZnO/BMG composite exhibited highly effective scavenging properties for the common free reactive oxygen radicals (DPPH [89.6 ± 1.5%], nitric oxide [90.2 ± 1.3%], ABTS [87.7 ± 1.8%], and O<sub>2</sub><sup>●−</sup> [46.7 ± 1.9%]) as compared to ascorbic acid. Additionally, its anti-diabetic activity was enhanced significantly and strongly inhibited essential oxidative enzymes (porcine α-amylase (90.6 ± 1.5%), crude α-amylase (84.3 ± 1.8%), pancreatic α-glucosidase (95.7 ± 1.4%), crude intestinal α-glucosidase (93.4 ± 1.8%), and amyloglucosidase (96.2 ± 1.4%)). Co-ZnO/BMG inhibitory activity was higher than that of miglitol, and in some cases, higher than or close to that of acarbose. Therefore, the synthetic Co-ZnO/BMG composite can be used as a commercial anti-diabetic and antioxidant agent, considering the cost and adverse side effects of current drugs. The results also demonstrate the impact of cobalt doping and BMG integration on the biological activity of ZnO.https://www.mdpi.com/1420-3049/28/9/3692seaweedZnOcobalt dopingantioxidantantidiabetes |
| spellingShingle | Hassan Ahmed Rudayni Abdelrahman M. Rabie Malak Aladwani Lina M. Alneghery Gasem M. Abu-Taweel Wail Al Zoubi Ahmed A. Allam Mostafa R. Abukhadra Stefano Bellucci Biological Activities of <i>Sargassum</i> Algae Mediated ZnO and Co Doped ZnO Nanoparticles as Enhanced Antioxidant and Anti-Diabetic Agents Molecules seaweed ZnO cobalt doping antioxidant antidiabetes |
| title | Biological Activities of <i>Sargassum</i> Algae Mediated ZnO and Co Doped ZnO Nanoparticles as Enhanced Antioxidant and Anti-Diabetic Agents |
| title_full | Biological Activities of <i>Sargassum</i> Algae Mediated ZnO and Co Doped ZnO Nanoparticles as Enhanced Antioxidant and Anti-Diabetic Agents |
| title_fullStr | Biological Activities of <i>Sargassum</i> Algae Mediated ZnO and Co Doped ZnO Nanoparticles as Enhanced Antioxidant and Anti-Diabetic Agents |
| title_full_unstemmed | Biological Activities of <i>Sargassum</i> Algae Mediated ZnO and Co Doped ZnO Nanoparticles as Enhanced Antioxidant and Anti-Diabetic Agents |
| title_short | Biological Activities of <i>Sargassum</i> Algae Mediated ZnO and Co Doped ZnO Nanoparticles as Enhanced Antioxidant and Anti-Diabetic Agents |
| title_sort | biological activities of i sargassum i algae mediated zno and co doped zno nanoparticles as enhanced antioxidant and anti diabetic agents |
| topic | seaweed ZnO cobalt doping antioxidant antidiabetes |
| url | https://www.mdpi.com/1420-3049/28/9/3692 |
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