A conjoint analysis of bulk RNA-seq and single-nucleus RNA-seq for revealing the role of ferroptosis and iron metabolism in ALS

A conjoint analysis of bulk RNA-seq and single-nucleus RNA-seq for revealing the role of ferroptosis and iron metabolism in ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive and selective degeneration of motor neurons in the motor cortex of brain and spinal cord. Ferroptosis is a newly discovered form of cell death and reported to mediate selective motor neuron death in the m...

Full description

Bibliographic Details
Main Authors: Xiujuan Fu, Yizi He, Yongzhi Xie, Zuneng Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Neuroscience
Subjects:
amyotrophic lateral sclerosis
ferroptosis
iron metabolism
single nuclear analysis
WGCNA
LASSO
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1113216/full

Similar Items

Similar Items