Tenogenic induction of human adipose-derived stem cells by soluble tendon extracellular matrix: composition and transcriptomic analyses

Tenogenic induction of human adipose-derived stem cells by soluble tendon extracellular matrix: composition and transcriptomic analyses

Abstract Background Tendon healing is clinically challenging largely due to its inferior regenerative capacity. We have previously prepared a soluble, DNA-free, urea-extracted bovine tendon-derived extracellular matrix (tECM) that exhibits strong pro-tenogenic bioactivity on human adipose-derived st...

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Bibliographic Details
Main Authors: Ying Rao, Chenxian Zhu, Hoi Ching Suen, Shuting Huang, Jinyue Liao, Dai Fei Elmer Ker, Rocky S. Tuan, Dan Wang
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Stem Cell Research & Therapy
Subjects:
Tendon
Extracellular matrix
Adipose-derived stem cells
Mass spectrometry
RNA sequencing
Bioinformatics
Online Access:https://doi.org/10.1186/s13287-022-03038-0

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