The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias
The MYC transcription factor is one of the best characterized PP2A substrates. Deregulation of the MYC oncogene, along with inactivation of PP2A, are two frequent events in cancer. Both proteins are essential regulators of cell proliferation, apoptosis, and differentiation, and they, directly and in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/3/544 |
| _version_ | 1797721884438036480 |
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| author | Raffaella Pippa Maria D. Odero |
| author_facet | Raffaella Pippa Maria D. Odero |
| author_sort | Raffaella Pippa |
| collection | DOAJ |
| description | The MYC transcription factor is one of the best characterized PP2A substrates. Deregulation of the MYC oncogene, along with inactivation of PP2A, are two frequent events in cancer. Both proteins are essential regulators of cell proliferation, apoptosis, and differentiation, and they, directly and indirectly, regulate each other’s activity. Studies in cancer suggest that targeting the MYC/PP2A network is an achievable strategy for the clinic. Here, we focus on and discuss the role of MYC and PP2A in myeloid leukemias. |
| first_indexed | 2024-03-12T09:39:33Z |
| format | Article |
| id | doaj.art-d23f955b5c02497a9b41b732a7d5ce3c |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T09:39:33Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-d23f955b5c02497a9b41b732a7d5ce3c2023-09-02T13:22:17ZengMDPI AGCells2073-44092020-02-019354410.3390/cells9030544cells9030544The Role of MYC and PP2A in the Initiation and Progression of Myeloid LeukemiasRaffaella Pippa0Maria D. Odero1Medical Oncology Department, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USACentro de Investigación Médica Aplicada (CIMA), University of Navarra, 31008 Pamplona, SpainThe MYC transcription factor is one of the best characterized PP2A substrates. Deregulation of the MYC oncogene, along with inactivation of PP2A, are two frequent events in cancer. Both proteins are essential regulators of cell proliferation, apoptosis, and differentiation, and they, directly and indirectly, regulate each other’s activity. Studies in cancer suggest that targeting the MYC/PP2A network is an achievable strategy for the clinic. Here, we focus on and discuss the role of MYC and PP2A in myeloid leukemias.https://www.mdpi.com/2073-4409/9/3/544pp2amycmyeloid leukemiaamlcml |
| spellingShingle | Raffaella Pippa Maria D. Odero The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias Cells pp2a myc myeloid leukemia aml cml |
| title | The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias |
| title_full | The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias |
| title_fullStr | The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias |
| title_full_unstemmed | The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias |
| title_short | The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias |
| title_sort | role of myc and pp2a in the initiation and progression of myeloid leukemias |
| topic | pp2a myc myeloid leukemia aml cml |
| url | https://www.mdpi.com/2073-4409/9/3/544 |
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