Effects of DNA damage on oocyte meiotic maturation and early embryonic development
DNA damage is one of the most common threats to meiotic cells. It has the potential to induce infertility and genetic abnormalities that may be passed to the embryo. Here, we reviewed exogenous factors which could induce DNA damage. Specially, we addressed the different effects of DNA damage on mous...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Higher Education Press
2014-09-01
|
| Series: | Frontiers of Agricultural Science and Engineering |
| Subjects: | |
| Online Access: | http://academic.hep.com.cn/fase/fileup/2095-7505/PDF/2095-7505-2014-3-185.pdf |
| _version_ | 1818153403821326336 |
|---|---|
| author | Shen YIN,Junyu MA,Wei SHEN |
| author_facet | Shen YIN,Junyu MA,Wei SHEN |
| author_sort | Shen YIN,Junyu MA,Wei SHEN |
| collection | DOAJ |
| description | DNA damage is one of the most common threats to meiotic cells. It has the potential to induce infertility and genetic abnormalities that may be passed to the embryo. Here, we reviewed exogenous factors which could induce DNA damage. Specially, we addressed the different effects of DNA damage on mouse oocytes and embryonic development. Complex DNA damage, double-strand breaks, represents a more difficult repair process and involves various repair pathways. Understanding the mechanisms involved in DNA damage responses may improve therapeutic strategies for ovarian cancer and fertility preservation. |
| first_indexed | 2024-12-11T14:10:04Z |
| format | Article |
| id | doaj.art-d2407200bacb485fbd19d12abb0355f4 |
| institution | Directory Open Access Journal |
| issn | 2095-7505 |
| language | English |
| last_indexed | 2024-12-11T14:10:04Z |
| publishDate | 2014-09-01 |
| publisher | Higher Education Press |
| record_format | Article |
| series | Frontiers of Agricultural Science and Engineering |
| spelling | doaj.art-d2407200bacb485fbd19d12abb0355f42022-12-22T01:03:29ZengHigher Education PressFrontiers of Agricultural Science and Engineering2095-75052014-09-011318519010.15302/J-FASE-2014035Effects of DNA damage on oocyte meiotic maturation and early embryonic developmentShen YIN,Junyu MA,Wei SHEN0Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, ChinaDNA damage is one of the most common threats to meiotic cells. It has the potential to induce infertility and genetic abnormalities that may be passed to the embryo. Here, we reviewed exogenous factors which could induce DNA damage. Specially, we addressed the different effects of DNA damage on mouse oocytes and embryonic development. Complex DNA damage, double-strand breaks, represents a more difficult repair process and involves various repair pathways. Understanding the mechanisms involved in DNA damage responses may improve therapeutic strategies for ovarian cancer and fertility preservation.http://academic.hep.com.cn/fase/fileup/2095-7505/PDF/2095-7505-2014-3-185.pdfDNA damage|double-strand breaks (DSBs)|oocyte|embryo |
| spellingShingle | Shen YIN,Junyu MA,Wei SHEN Effects of DNA damage on oocyte meiotic maturation and early embryonic development Frontiers of Agricultural Science and Engineering DNA damage|double-strand breaks (DSBs)|oocyte|embryo |
| title | Effects of DNA damage on oocyte meiotic maturation and early embryonic development |
| title_full | Effects of DNA damage on oocyte meiotic maturation and early embryonic development |
| title_fullStr | Effects of DNA damage on oocyte meiotic maturation and early embryonic development |
| title_full_unstemmed | Effects of DNA damage on oocyte meiotic maturation and early embryonic development |
| title_short | Effects of DNA damage on oocyte meiotic maturation and early embryonic development |
| title_sort | effects of dna damage on oocyte meiotic maturation and early embryonic development |
| topic | DNA damage|double-strand breaks (DSBs)|oocyte|embryo |
| url | http://academic.hep.com.cn/fase/fileup/2095-7505/PDF/2095-7505-2014-3-185.pdf |
| work_keys_str_mv | AT shenyinjunyumaweishen effectsofdnadamageonoocytemeioticmaturationandearlyembryonicdevelopment |