Layer-by-layer modification strategies for electrochemical detection of biomarkers
In the last decades, the use of electrochemical and electrode modification-based biosensors has aroused great research interest in widely different applications such as medical diagnostics, drug analysis, environmental monitoring, food analysis, and biochemical analysis. Moreover, the use of various...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Biosensors and Bioelectronics: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590137022001637 |
| _version_ | 1811187550050582528 |
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| author | Cem Erkmen Ozge Selcuk Didem Nur Unal Sevinc Kurbanoglu Bengi Uslu |
| author_facet | Cem Erkmen Ozge Selcuk Didem Nur Unal Sevinc Kurbanoglu Bengi Uslu |
| author_sort | Cem Erkmen |
| collection | DOAJ |
| description | In the last decades, the use of electrochemical and electrode modification-based biosensors has aroused great research interest in widely different applications such as medical diagnostics, drug analysis, environmental monitoring, food analysis, and biochemical analysis. Moreover, the use of various nanomaterials for electrode modifications and the production of these modifications based on the layer-by-layer film deposition techniques have provided significant advantages in the production of stable and sensitive sensors that provide a large surface area. In this review, the applications of electrochemical methods developed for the determination of major biomarkers that are important in the diagnosis of different diseases are discussed. In three main categories, diseases and related biomarkers, electrochemical sensors and modification strategies, and applications of prepared electrodes according to the layer-by-layer strategy are described. Current biosensors, operating conditions, some validation characteristics, and applications reported to detect several biomarkers in the last four years are presented to the researchers in a table. Moreover, conclusions and future perspectives are presented, highlighting some ongoing challenges and some topics for improvement to maximize sensor sensitivity. |
| first_indexed | 2024-04-11T14:04:12Z |
| format | Article |
| id | doaj.art-d2416e28a9ca478485ab6903b7c0f17b |
| institution | Directory Open Access Journal |
| issn | 2590-1370 |
| language | English |
| last_indexed | 2024-04-11T14:04:12Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biosensors and Bioelectronics: X |
| spelling | doaj.art-d2416e28a9ca478485ab6903b7c0f17b2022-12-22T04:19:57ZengElsevierBiosensors and Bioelectronics: X2590-13702022-12-0112100270Layer-by-layer modification strategies for electrochemical detection of biomarkersCem Erkmen0Ozge Selcuk1Didem Nur Unal2Sevinc Kurbanoglu3Bengi Uslu4Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06560, Ankara, Turkey; Ankara University, The Graduate School of Health Sciences, 06110, Ankara, TurkeyAnkara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06560, Ankara, Turkey; Ankara University, The Graduate School of Health Sciences, 06110, Ankara, TurkeyAnkara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06560, Ankara, Turkey; Ankara University, The Graduate School of Health Sciences, 06110, Ankara, TurkeyAnkara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06560, Ankara, TurkeyAnkara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06560, Ankara, Turkey; Corresponding author.In the last decades, the use of electrochemical and electrode modification-based biosensors has aroused great research interest in widely different applications such as medical diagnostics, drug analysis, environmental monitoring, food analysis, and biochemical analysis. Moreover, the use of various nanomaterials for electrode modifications and the production of these modifications based on the layer-by-layer film deposition techniques have provided significant advantages in the production of stable and sensitive sensors that provide a large surface area. In this review, the applications of electrochemical methods developed for the determination of major biomarkers that are important in the diagnosis of different diseases are discussed. In three main categories, diseases and related biomarkers, electrochemical sensors and modification strategies, and applications of prepared electrodes according to the layer-by-layer strategy are described. Current biosensors, operating conditions, some validation characteristics, and applications reported to detect several biomarkers in the last four years are presented to the researchers in a table. Moreover, conclusions and future perspectives are presented, highlighting some ongoing challenges and some topics for improvement to maximize sensor sensitivity.http://www.sciencedirect.com/science/article/pii/S2590137022001637BiomarkerBiosensorDeterminationElectrochemistryLayer-by-layer |
| spellingShingle | Cem Erkmen Ozge Selcuk Didem Nur Unal Sevinc Kurbanoglu Bengi Uslu Layer-by-layer modification strategies for electrochemical detection of biomarkers Biosensors and Bioelectronics: X Biomarker Biosensor Determination Electrochemistry Layer-by-layer |
| title | Layer-by-layer modification strategies for electrochemical detection of biomarkers |
| title_full | Layer-by-layer modification strategies for electrochemical detection of biomarkers |
| title_fullStr | Layer-by-layer modification strategies for electrochemical detection of biomarkers |
| title_full_unstemmed | Layer-by-layer modification strategies for electrochemical detection of biomarkers |
| title_short | Layer-by-layer modification strategies for electrochemical detection of biomarkers |
| title_sort | layer by layer modification strategies for electrochemical detection of biomarkers |
| topic | Biomarker Biosensor Determination Electrochemistry Layer-by-layer |
| url | http://www.sciencedirect.com/science/article/pii/S2590137022001637 |
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