A Study on Acetylglutamine Pharmacokinetics in Rat Blood and Brain Based on Liquid Chromatography-Tandem Mass Spectrometry and Microdialysis Technique

A Study on Acetylglutamine Pharmacokinetics in Rat Blood and Brain Based on Liquid Chromatography-Tandem Mass Spectrometry and Microdialysis Technique

Acetylglutamine (NAG) is the derivative of glutamine, which is the richest free amino acid in the human body. In this work, a novel reliable method of the combination of liquid chromatography-tandem mass spectrometry (LC-MS/MS) and microdialysis (MD) technique for the evaluation of NAG and its metab...

Full description

Bibliographic Details
Main Authors:	Shouchao Xu, Chang Li, Huifen Zhou, Li Yu, Ling Deng, Jiazhen Zhu, Haitong Wan, Yu He
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-04-01
Series:	Frontiers in Pharmacology
Subjects:	liquid chromatography-tandem mass spectrometry acetylglutamine glutamic acid γ-aminobutyric acid microdialysis blood-brain barrier
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2020.00508/full

Similar Items

Acetylglutamine facilitates motor recovery and alleviates neuropathic pain after brachial plexus root avulsion in rats
by: Lin Wu, et al.
Published: (2023-08-01)

Characterization of three glutamate decarboxylases from Bacillus spp. for efficient γ-aminobutyric acid production
by: Lei Sun, et al.
Published: (2021-08-01)

Methanol extract of Nigella sativa seed induces changes in the levels of neurotransmitter amino acids in male rat brain regions
by: Tarek El-Naggar, et al.
Published: (2017-01-01)

Evaluation of commercial soy sauce koji strains of Aspergillus oryzae for γ-aminobutyric acid (GABA) production
by: Ab Kadir, Safuan, et al.
Published: (2016)

GABA transaminase deficiency. Case report and literature review
by: Amira Oshi, et al.
Published: (2021-03-01)

Vitexin Possesses Anticonvulsant and Anxiolytic-Like Effects in Murine Animal Models
by: Denise Dias de Oliveira, et al.
Published: (2020-08-01)

Optimization of ultra-performance liquid chromatography (UPLC) with fluorescence detector (FLD) method for the quantitative determination of selected neurotransmitters in rat brain
by: Joanna Stragierowicz, et al.
Published: (2017-10-01)

The use of deuterium-labeled gamma-aminobutyric (D6-GABA) to study uptake, translocation, and metabolism of exogenous GABA in plants
by: Faraj Hijaz, et al.
Published: (2020-02-01)

On-line near-infrared spectroscopy optimizing and monitoring biotransformation process of γ-aminobutyric acid
by: Guoyu Ding, et al.
Published: (2016-06-01)

Sex Differences and Role of Gonadal Hormones on Glutamate Level After Spinal Cord Injury in Rats: A Microdialysis Study
by: Razieh Samandari, et al.
Published: (2019-05-01)

Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue
by: N.M. Jadavji, et al.
Published: (2015-06-01)

Effect and Process Conditions of Cold Plasma Combined withL-Glutamic Acid and Salt Stress on Germination and Enrichment ofγ-Aminobutyric Acid in Adzuki Bean
by: Qingpeng XU, et al.
Published: (2023-11-01)

Optimization of Conditions for γ-Aminobutyric Acid Yield by Co-fermentation of Enterococcus faecium with Saccharomyces cerevisiae and Mechanism Research
by: Xiangyang SUN, et al.
Published: (2022-08-01)

The Effect of Microdialysis Catheter Insertion on Glutamate and Serotonin Levels in Masseter Muscle in Patients with Myofascial Temporomandibular Disorders and Healthy Controls
by: Ermira Bajramaj, et al.
Published: (2019-01-01)

A Novel Method for γ-Aminobutyric Acid Biosynthesis Using Glutamate Decarboxylase Entrapped in Polyvinyl Alcohol–Sodium Alginate Capsules
by: Fei Zhu, et al.
Published: (2023-09-01)

Site‐directed mutagenesis improves the practical application of L‐glutamic acid decarboxylase in Escherichia coli
by: Liu Fengmin, et al.
Published: (2023-04-01)

High-level production of γ-aminobutyric acid via efficient co-expression of the key genes of glutamate decarboxylase system in Escherichia coli
by: Lili Yao, et al.
Published: (2023-06-01)

Identification of new glutamate decarboxylases from Streptomyces for efficient production of γ-aminobutyric acid in engineered Escherichia coli
by: Haina Yuan, et al.
Published: (2019-03-01)

Modelling a microdialysis probe for analysis of skin wound metabolism /
by: Nuraini Mohd. Isa, 1987-, author, et al.
Published: (2011)

Modelling a microdialysis probe for analysis of skin wound metabolism /
by: Nuraini Mohd. Isa, 1987-, author, et al.
Published: (2011)

KangPiLao decoction modulates cognitive and emotional disorders in rats with central fatigue through the GABA/Glu pathway
by: Yifei Xu, et al.
Published: (2022-09-01)

Partial Cloning and Nucleotide Sequencing of Glutamate Decarboxylase Gene Isoform 65 from Human Brain
by: Abolghasem Esmaeili, et al.
Published: (2015-04-01)

The γ-Aminobutyric Acid (GABA) Synthesis Gene Regulates the Resistance to Water Core-Induced Hypoxia Stress for Pear Fruits
by: Xiao Liu, et al.
Published: (2023-04-01)

Muscimol Directly Activates the TREK-2 Channel Expressed in GABAergic Neurons through Its N-Terminus
by: Eun-Jin Kim, et al.
Published: (2021-08-01)

Lilium davidii extract alleviates p‑chlorophenylalanine‑induced insomnia in rats through modification of the hypothalamic-related neurotransmitters, melatonin and homeostasis of the hypothalamic-pituitary-adrenal axis
by: Yanpo Si, et al.
Published: (2020-01-01)

Microdialysis Determination of Cefquinome Pharmacokinetics in Murine Thigh From Healthy, Neutropenic, and Actinobacillus pleuropneumoniae-Infected Mice
by: Longfei Zhang, et al.
Published: (2019-03-01)

Effects of tandem fermentation of edible mushroom and L. plantarum on sensory, polysaccharide, vitamin C, and γ-aminobutyric acid of Rosa roxburghii Tratt and coix seed beverage
by: Mengqi Liu, et al.
Published: (2023-12-01)

Sleep and Microdialysis: An Experiment and a Systematic Review of Histamine and Several Amino Acids
by: Cathalijn H. C. Leenaars, et al.
Published: (2019-07-01)

Probiotic Ameliorating Effects of Altered GABA/Glutamate Signaling in a Rodent Model of Autism
by: Rawan M. Bin-Khattaf, et al.
Published: (2022-08-01)

Examining the Role of GLU/GABA to GLN Metabolic Cycle in the Pathogenesis of Post-Stroke Depressive Disorder and Insomnia
by: Zhang XH, et al.
Published: (2023-12-01)

Calcium Involved in the Enrichment of γ-Aminobutyric Acid (GABA) in Broccoli Sprouts under Fructose Treatment
by: Qinling Wei, et al.
Published: (2023-01-01)

High hydrostatic pressure increases the biosynthesis of γ-aminobutyric acid using bee pollen as a novel and eco-friendly catalyst
by: Tuhanguli Tuoheti, et al.
Published: (2020-07-01)

Excitatory and inhibitory responses in the brain to experimental pain: A systematic review of MR spectroscopy studies
by: Jessica Archibald, et al.
Published: (2020-07-01)

Effects of γ-aminobutyric acid on feed intake, growth performance and expression of related genes in growing lambs
by: D.M. Wang, et al.
Published: (2015-01-01)

A Systematic Search and Mapping Review of Studies on Intracerebral Microdialysis of Amino Acids, and Systematized Review of Studies on Circadian Rhythms
by: Cathalijn H. C. Leenaars, et al.
Published: (2018-10-01)

Effects of Germination on the Content of Amino Acids and Anti-nutritional Factors of Sorghum Grain
by: Jun ZHANG, et al.
Published: (2022-01-01)

γ-aminobutyric acid alleviates LPS-induced acute lung injury in mice through upregulating type B receptors
by: Jing Yang, et al.
Published: (2019-11-01)

Glutamate Decarboxylase from Lactic Acid Bacteria—A Key Enzyme in GABA Synthesis
by: Ida Bagus Agung Yogeswara, et al.
Published: (2020-12-01)

Optimization of γ-Aminobutyric Acid Production by Lactobacillus plantarum Taj-Apis362 from Honeybees
by: Naser Tajabadi, et al.
Published: (2015-04-01)

Cloning and Expression Vector Construction of Glutamate Decarboxylase Gene from Lactobacillus Plantarum
by: B Arabpour, et al.
Published: (2016-06-01)