Effect of probiotic Enterococcus faecium SF68 on liver function in healthy dogs
Abstract Background Probiotics are widely used in dogs but can be associated with alterations in some serum biochemistry test results. Objective To assess the effect of Enterococcus faecium SF68 administration for 14 days on serum alanine transferase (ALT) and alkaline phosphatase (ALP) activity and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-11-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.15625 |
| _version_ | 1829498946254274560 |
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| author | Rosario Lucena Manuel Novales Beatriz Blanco Eduardo Hernández Pedro José Ginel |
| author_facet | Rosario Lucena Manuel Novales Beatriz Blanco Eduardo Hernández Pedro José Ginel |
| author_sort | Rosario Lucena |
| collection | DOAJ |
| description | Abstract Background Probiotics are widely used in dogs but can be associated with alterations in some serum biochemistry test results. Objective To assess the effect of Enterococcus faecium SF68 administration for 14 days on serum alanine transferase (ALT) and alkaline phosphatase (ALP) activity and total cholesterol and triglyceride concentrations in healthy dogs. Animals Thirty‐six healthy privately owned neutered dogs were randomly allocated, stratified by sex, to control or probiotic groups. Dogs were clinically healthy, with normal physical examination findings, blood, urine, and fecal analyses and ultrasonographic examinations. Method In this blinded, controlled study E. faecium SF68 was administered to the probiotic group for 14 days. Blood samples were taken from all dogs at days 0, 14, and 28. Serum ALT and ALP activity and total cholesterol and triglyceride concentrations were determined on these 3 days. Results The probiotic induced no significant changes in mean ALT and ALP activity. Mean cholesterol concentration did not change during probiotic administration but a significant decrease was seen on day 28 (P < .01). Mean triglyceride concentration increased progressively, becoming significant at day 28 (P < .05), with 1 dog developing hypertriglyceridemia. Conclusions and Clinical Importance E. faecium SF68 would not create confusion when monitoring dogs with hepatobiliary disease because ALT and ALP activity did not change significantly. A significant decrease in cholesterol and significant increase in triglyceride concentrations were seen at day 28 but were not clinically relevant, with 1 dog showing hypertriglyceridemia. A longer trial is warranted to assess if the probiotic effects could be clinically relevant and to assess its potential use in hypertriglyceridemic dogs. |
| first_indexed | 2024-12-16T08:23:55Z |
| format | Article |
| id | doaj.art-d2421bf6accf473097d6cc9c00f50948 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-12-16T08:23:55Z |
| publishDate | 2019-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-d2421bf6accf473097d6cc9c00f509482022-12-21T22:38:03ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762019-11-013362628263410.1111/jvim.15625Effect of probiotic Enterococcus faecium SF68 on liver function in healthy dogsRosario Lucena0Manuel Novales1Beatriz Blanco2Eduardo Hernández3Pedro José Ginel4Department of Animal Medicine and Surgery Faculty of Veterinary Medicine of Córdoba, Campus of Rabanales Córdoba SpainDepartment of Animal Medicine and Surgery Faculty of Veterinary Medicine of Córdoba, Campus of Rabanales Córdoba SpainDepartment of Animal Medicine and Surgery Faculty of Veterinary Medicine of Córdoba, Campus of Rabanales Córdoba SpainDepartment of Animal Medicine and Surgery Faculty of Veterinary Medicine of Córdoba, Campus of Rabanales Córdoba SpainDepartment of Animal Medicine and Surgery Faculty of Veterinary Medicine of Córdoba, Campus of Rabanales Córdoba SpainAbstract Background Probiotics are widely used in dogs but can be associated with alterations in some serum biochemistry test results. Objective To assess the effect of Enterococcus faecium SF68 administration for 14 days on serum alanine transferase (ALT) and alkaline phosphatase (ALP) activity and total cholesterol and triglyceride concentrations in healthy dogs. Animals Thirty‐six healthy privately owned neutered dogs were randomly allocated, stratified by sex, to control or probiotic groups. Dogs were clinically healthy, with normal physical examination findings, blood, urine, and fecal analyses and ultrasonographic examinations. Method In this blinded, controlled study E. faecium SF68 was administered to the probiotic group for 14 days. Blood samples were taken from all dogs at days 0, 14, and 28. Serum ALT and ALP activity and total cholesterol and triglyceride concentrations were determined on these 3 days. Results The probiotic induced no significant changes in mean ALT and ALP activity. Mean cholesterol concentration did not change during probiotic administration but a significant decrease was seen on day 28 (P < .01). Mean triglyceride concentration increased progressively, becoming significant at day 28 (P < .05), with 1 dog developing hypertriglyceridemia. Conclusions and Clinical Importance E. faecium SF68 would not create confusion when monitoring dogs with hepatobiliary disease because ALT and ALP activity did not change significantly. A significant decrease in cholesterol and significant increase in triglyceride concentrations were seen at day 28 but were not clinically relevant, with 1 dog showing hypertriglyceridemia. A longer trial is warranted to assess if the probiotic effects could be clinically relevant and to assess its potential use in hypertriglyceridemic dogs.https://doi.org/10.1111/jvim.15625dogenterococcusliver functionprobiotic |
| spellingShingle | Rosario Lucena Manuel Novales Beatriz Blanco Eduardo Hernández Pedro José Ginel Effect of probiotic Enterococcus faecium SF68 on liver function in healthy dogs Journal of Veterinary Internal Medicine dog enterococcus liver function probiotic |
| title | Effect of probiotic Enterococcus faecium SF68 on liver function in healthy dogs |
| title_full | Effect of probiotic Enterococcus faecium SF68 on liver function in healthy dogs |
| title_fullStr | Effect of probiotic Enterococcus faecium SF68 on liver function in healthy dogs |
| title_full_unstemmed | Effect of probiotic Enterococcus faecium SF68 on liver function in healthy dogs |
| title_short | Effect of probiotic Enterococcus faecium SF68 on liver function in healthy dogs |
| title_sort | effect of probiotic enterococcus faecium sf68 on liver function in healthy dogs |
| topic | dog enterococcus liver function probiotic |
| url | https://doi.org/10.1111/jvim.15625 |
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