Lymphatic system and adipose tissue: Crosstalk in health and disease
The lymphatic system (LS) is one of the main integrative systems of the body, providing protective and transport functions. In recent years, interactions between LS and adipose tissue (AT) have been of particular interest. Lymphatic vessels play an important role in metabolic and regulatory function...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2021-10-01
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| Series: | Ожирение и метаболизм |
| Subjects: | |
| Online Access: | https://www.omet-endojournals.ru/jour/article/view/12776 |
| _version_ | 1797204562644303872 |
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| author | V. V. Klimontov D. M. Bulumbaeva |
| author_facet | V. V. Klimontov D. M. Bulumbaeva |
| author_sort | V. V. Klimontov |
| collection | DOAJ |
| description | The lymphatic system (LS) is one of the main integrative systems of the body, providing protective and transport functions. In recent years, interactions between LS and adipose tissue (AT) have been of particular interest. Lymphatic vessels play an important role in metabolic and regulatory functions of AT, acting as a collector of lipolysis products and adipokines. In its turn, hormones and adipocytokines that produced in adipocytes (including leptin, adiponectin, IL-6, TNF-α, etc.) affect the function of lymphatic endothelial cells and control the growth of lymphatic vessels. Cooperation between LS and AT becomes pathogenetically and clinically important in lymphedema and obesity. It is known that both primary and secondary lymphedema are characterized by increased fat accumulation which is associated with the severity of lymphostasis and inflammation. Similarly, in obesity, the drainage function of LS is impaired, which is accompanied by perilymphatic mononuclear infiltration in the AT. The development of these changes is facilitated by endocrine dysfunction of adipocytes and impaired production of adipocytokines. The increase in the production of inflammatory mediators and the disruption of the traffic of inflammatory cells causes a further deterioration in the outflow of interstitial fluid and exacerbates the inflammation of the AT, thereby forming a vicious circle. The role of lymphangiogenesis in AT remodeling in obesity needs further research. Another promising area of research is the study of the role of intestinal LS in the development of obesity and related disorders. It has been shown that the transport of chylomicrons from the intestine depends on the expression of a number of molecular mediators (VEGF-C, DLL-4, neuropilin-1, VEGFR-1, CD36/FAT, etc.)in the endotheliocytes of the intestinal lymphatic vessels, as well as the functioning of «push-button» and “zippering” junctions between endothelial cells. New approach to the treatment of obesity based on blockade of lymphatic chylomicrontransport has been experimentally substantiated. Further identification of the molecular mechanisms and signaling pathways that determine the remodeling of AT in lymphedema and obesity are likely to provide new approaches to the treatment of these diseases. |
| first_indexed | 2024-03-08T09:12:36Z |
| format | Article |
| id | doaj.art-d2425ea0efb949e8b381abd7058daa71 |
| institution | Directory Open Access Journal |
| issn | 2071-8713 2306-5524 |
| language | English |
| last_indexed | 2024-04-24T08:37:12Z |
| publishDate | 2021-10-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Ожирение и метаболизм |
| spelling | doaj.art-d2425ea0efb949e8b381abd7058daa712024-04-16T16:16:13ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242021-10-0118333634410.14341/omet1277610889Lymphatic system and adipose tissue: Crosstalk in health and diseaseV. V. Klimontov0D. M. Bulumbaeva1Research Institute of Clinical and Experimental Lymphology — Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of SciencesResearch Institute of Clinical and Experimental Lymphology — Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of SciencesThe lymphatic system (LS) is one of the main integrative systems of the body, providing protective and transport functions. In recent years, interactions between LS and adipose tissue (AT) have been of particular interest. Lymphatic vessels play an important role in metabolic and regulatory functions of AT, acting as a collector of lipolysis products and adipokines. In its turn, hormones and adipocytokines that produced in adipocytes (including leptin, adiponectin, IL-6, TNF-α, etc.) affect the function of lymphatic endothelial cells and control the growth of lymphatic vessels. Cooperation between LS and AT becomes pathogenetically and clinically important in lymphedema and obesity. It is known that both primary and secondary lymphedema are characterized by increased fat accumulation which is associated with the severity of lymphostasis and inflammation. Similarly, in obesity, the drainage function of LS is impaired, which is accompanied by perilymphatic mononuclear infiltration in the AT. The development of these changes is facilitated by endocrine dysfunction of adipocytes and impaired production of adipocytokines. The increase in the production of inflammatory mediators and the disruption of the traffic of inflammatory cells causes a further deterioration in the outflow of interstitial fluid and exacerbates the inflammation of the AT, thereby forming a vicious circle. The role of lymphangiogenesis in AT remodeling in obesity needs further research. Another promising area of research is the study of the role of intestinal LS in the development of obesity and related disorders. It has been shown that the transport of chylomicrons from the intestine depends on the expression of a number of molecular mediators (VEGF-C, DLL-4, neuropilin-1, VEGFR-1, CD36/FAT, etc.)in the endotheliocytes of the intestinal lymphatic vessels, as well as the functioning of «push-button» and “zippering” junctions between endothelial cells. New approach to the treatment of obesity based on blockade of lymphatic chylomicrontransport has been experimentally substantiated. Further identification of the molecular mechanisms and signaling pathways that determine the remodeling of AT in lymphedema and obesity are likely to provide new approaches to the treatment of these diseases.https://www.omet-endojournals.ru/jour/article/view/12776lymphatic systemadipose tissuelymphangiogenesislymphedemaobesity |
| spellingShingle | V. V. Klimontov D. M. Bulumbaeva Lymphatic system and adipose tissue: Crosstalk in health and disease Ожирение и метаболизм lymphatic system adipose tissue lymphangiogenesis lymphedema obesity |
| title | Lymphatic system and adipose tissue: Crosstalk in health and disease |
| title_full | Lymphatic system and adipose tissue: Crosstalk in health and disease |
| title_fullStr | Lymphatic system and adipose tissue: Crosstalk in health and disease |
| title_full_unstemmed | Lymphatic system and adipose tissue: Crosstalk in health and disease |
| title_short | Lymphatic system and adipose tissue: Crosstalk in health and disease |
| title_sort | lymphatic system and adipose tissue crosstalk in health and disease |
| topic | lymphatic system adipose tissue lymphangiogenesis lymphedema obesity |
| url | https://www.omet-endojournals.ru/jour/article/view/12776 |
| work_keys_str_mv | AT vvklimontov lymphaticsystemandadiposetissuecrosstalkinhealthanddisease AT dmbulumbaeva lymphaticsystemandadiposetissuecrosstalkinhealthanddisease |