Synthesis, Characterization and Antitumor Mechanism Investigation of Heterometallic Ru(Ⅱ)-Re(Ⅰ) Complexes
The development of heteronuclear metal complexes as potent anticancer agents has received increasing attention in recent years. In this study, two new heteronuclear Ru(Ⅱ)-Re(Ⅰ) metal complexes, [Ru(bpy)2LRe(CO)3(DIP)](PF6)3 and [Ru(phen)2LRe(CO)3(DIP)](PF6)3 [RuRe-1 and RuRe-2, L = 2-(4-pyridinyl)im...
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.890925/full |
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| author | Xiurong Ma Junjian Lu Peixin Yang Bo Huang Rongtao Li Ruirong Ye |
| author_facet | Xiurong Ma Junjian Lu Peixin Yang Bo Huang Rongtao Li Ruirong Ye |
| author_sort | Xiurong Ma |
| collection | DOAJ |
| description | The development of heteronuclear metal complexes as potent anticancer agents has received increasing attention in recent years. In this study, two new heteronuclear Ru(Ⅱ)-Re(Ⅰ) metal complexes, [Ru(bpy)2LRe(CO)3(DIP)](PF6)3 and [Ru(phen)2LRe(CO)3(DIP)](PF6)3 [RuRe-1 and RuRe-2, L = 2-(4-pyridinyl)imidazolio[4,5-f][1,10]phenanthroline, bpy = 2,2′-bipyridine, DIP = 4,7-diphenyl-1,10-phenanthroline, phen = 1,10-phenanthroline], were synthesized and characterized. Cytotoxicity assay shows that RuRe-1 and RuRe-2 exhibit higher anticancer activity than cisplatin, and exist certain selectivity toward human cancer cells over normal cells. The anticancer mechanistic studies reveal that RuRe-1 and RuRe-2 can induce apoptosis through the regulation of cell cycle, depolarization of mitochondrial membrane potential (MMP), elevation of intracellular reactive oxygen species (ROS), and caspase cascade. Moreover, RuRe-1 and RuRe-2 can effectively inhibit cell migration and colony formation. Taken together, heteronuclear Ru(Ⅱ)-Re(Ⅰ) metal complexes possess the prospect of developing new anticancer agents with high efficacy. |
| first_indexed | 2024-04-12T11:21:27Z |
| format | Article |
| id | doaj.art-d243a84893414c089515c746a32532dc |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-12T11:21:27Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Chemistry |
| spelling | doaj.art-d243a84893414c089515c746a32532dc2022-12-22T03:35:21ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-05-011010.3389/fchem.2022.890925890925Synthesis, Characterization and Antitumor Mechanism Investigation of Heterometallic Ru(Ⅱ)-Re(Ⅰ) ComplexesXiurong Ma0Junjian Lu1Peixin Yang2Bo Huang3Rongtao Li4Ruirong Ye5Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, ChinaFaculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, ChinaFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, ChinaThe development of heteronuclear metal complexes as potent anticancer agents has received increasing attention in recent years. In this study, two new heteronuclear Ru(Ⅱ)-Re(Ⅰ) metal complexes, [Ru(bpy)2LRe(CO)3(DIP)](PF6)3 and [Ru(phen)2LRe(CO)3(DIP)](PF6)3 [RuRe-1 and RuRe-2, L = 2-(4-pyridinyl)imidazolio[4,5-f][1,10]phenanthroline, bpy = 2,2′-bipyridine, DIP = 4,7-diphenyl-1,10-phenanthroline, phen = 1,10-phenanthroline], were synthesized and characterized. Cytotoxicity assay shows that RuRe-1 and RuRe-2 exhibit higher anticancer activity than cisplatin, and exist certain selectivity toward human cancer cells over normal cells. The anticancer mechanistic studies reveal that RuRe-1 and RuRe-2 can induce apoptosis through the regulation of cell cycle, depolarization of mitochondrial membrane potential (MMP), elevation of intracellular reactive oxygen species (ROS), and caspase cascade. Moreover, RuRe-1 and RuRe-2 can effectively inhibit cell migration and colony formation. Taken together, heteronuclear Ru(Ⅱ)-Re(Ⅰ) metal complexes possess the prospect of developing new anticancer agents with high efficacy.https://www.frontiersin.org/articles/10.3389/fchem.2022.890925/fullheteronuclear metal complexesruthenium(II) complexesrhenium(I) complexesanticancer activityapoptosis |
| spellingShingle | Xiurong Ma Junjian Lu Peixin Yang Bo Huang Rongtao Li Ruirong Ye Synthesis, Characterization and Antitumor Mechanism Investigation of Heterometallic Ru(Ⅱ)-Re(Ⅰ) Complexes Frontiers in Chemistry heteronuclear metal complexes ruthenium(II) complexes rhenium(I) complexes anticancer activity apoptosis |
| title | Synthesis, Characterization and Antitumor Mechanism Investigation of Heterometallic Ru(Ⅱ)-Re(Ⅰ) Complexes |
| title_full | Synthesis, Characterization and Antitumor Mechanism Investigation of Heterometallic Ru(Ⅱ)-Re(Ⅰ) Complexes |
| title_fullStr | Synthesis, Characterization and Antitumor Mechanism Investigation of Heterometallic Ru(Ⅱ)-Re(Ⅰ) Complexes |
| title_full_unstemmed | Synthesis, Characterization and Antitumor Mechanism Investigation of Heterometallic Ru(Ⅱ)-Re(Ⅰ) Complexes |
| title_short | Synthesis, Characterization and Antitumor Mechanism Investigation of Heterometallic Ru(Ⅱ)-Re(Ⅰ) Complexes |
| title_sort | synthesis characterization and antitumor mechanism investigation of heterometallic ru ii re i complexes |
| topic | heteronuclear metal complexes ruthenium(II) complexes rhenium(I) complexes anticancer activity apoptosis |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.890925/full |
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