CCDC58 is a potential biomarker for diagnosis, prognosis, immunity, and genomic heterogeneity in pan-cancer
Abstract Coiled-coil domain-containing 58 (CCDC58) is a member of the CCDC protein family. Similar to other members, CCDC58 exhibits potential tumorigenic roles in a variety of malignancies. However, there is no systematic and comprehensive pan-cancer analysis to investigate the diagnosis, prognosis...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-04-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-59154-9 |
| _version_ | 1797209440734150656 |
|---|---|
| author | Kai Yang Yan Ma Weigang Chen Lu Liu Zelong Yang Chaokui He Nanbei Zheng Xinyu Liu Xin Cheng Junbo Song Yong Chen Hongyu Qiao Ruohan Zhang |
| author_facet | Kai Yang Yan Ma Weigang Chen Lu Liu Zelong Yang Chaokui He Nanbei Zheng Xinyu Liu Xin Cheng Junbo Song Yong Chen Hongyu Qiao Ruohan Zhang |
| author_sort | Kai Yang |
| collection | DOAJ |
| description | Abstract Coiled-coil domain-containing 58 (CCDC58) is a member of the CCDC protein family. Similar to other members, CCDC58 exhibits potential tumorigenic roles in a variety of malignancies. However, there is no systematic and comprehensive pan-cancer analysis to investigate the diagnosis, prognosis, immune infiltration, and other related functions of CCDC58. We used several online websites and databases, such as TCGA, GTEx, UALCAN, HPA, CancerSEA, BioGRID, GEPIA 2.0, TIMER 2.0, and TISIDB, to extract CCDC58 expression data and clinical data of patients in pan-cancer. Then, the relationship between CCDC58 expression and diagnosis, prognosis, genetic alterations, DNA methylation, genomic heterogeneity, and immune infiltration level were determined. In addition, the biological function of CCDC58 in liver hepatocellular carcinoma (LIHC) was investigated. Pan-cancer analysis results showed that CCDC58 was differentially expressed in most tumors and showed excellent performance in diagnosis and prediction of prognosis. The expression of CCDC58 was highly correlated with genetic alterations, DNA methylation, and genomic heterogeneity in some tumors. In addition, the correlation analysis of CCDC58 with the level of immune infiltration and immune checkpoint marker genes indicated that CCDC58 might affect the composition of the tumor immune microenvironment. Enrichment analysis showed that CCDC58-related genes were mainly linked to mitosis, chromosome, and cell cycle. Finally, biological function experiments demonstrated that CCDC58 plays an important role in tumor cell proliferation and migration. CCDC58 was first identified as a pan-cancer biomarker. It may be used as a potential therapeutic target to improve the prognosis of patients in the future. |
| first_indexed | 2024-04-24T09:54:44Z |
| format | Article |
| id | doaj.art-d2442bc725de4ca599a953e48850d345 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T09:54:44Z |
| publishDate | 2024-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d2442bc725de4ca599a953e48850d3452024-04-14T11:14:23ZengNature PortfolioScientific Reports2045-23222024-04-0114111910.1038/s41598-024-59154-9CCDC58 is a potential biomarker for diagnosis, prognosis, immunity, and genomic heterogeneity in pan-cancerKai Yang0Yan Ma1Weigang Chen2Lu Liu3Zelong Yang4Chaokui He5Nanbei Zheng6Xinyu Liu7Xin Cheng8Junbo Song9Yong Chen10Hongyu Qiao11Ruohan Zhang12Department of Hepatobiliary Surgery, Xi Jing Hospital, Air Force Medical UniversityDepartment of Gynecology and Obstetrics, Xi Jing Hospital, Air Force Medical UniversityDepartment of Hepatobiliary Surgery, Xi Jing Hospital, Air Force Medical UniversityCollege of Life Sciences, Northwest UniversityDepartment of Hepatobiliary Surgery, Xi Jing Hospital, Air Force Medical UniversityDepartment of Oncology, The First Affiliated Hospital of Shanxi Medical UniversityDepartment of General Surgery, The First Affiliated Hospital of Jiamusi UniversityDepartment of Hepatobiliary Surgery, Xi Jing Hospital, Air Force Medical UniversityDepartment of Hepatobiliary Surgery, Xi Jing Hospital, Air Force Medical UniversityDepartment of Hepatobiliary Surgery, Xi Jing Hospital, Air Force Medical UniversityDepartment of Hepatobiliary Surgery, Xi Jing Hospital, Air Force Medical UniversityDepartment of Pediatrics, Xi Jing Hospital, Air Force Medical UniversityDepartment of Hepatobiliary Surgery, Xi Jing Hospital, Air Force Medical UniversityAbstract Coiled-coil domain-containing 58 (CCDC58) is a member of the CCDC protein family. Similar to other members, CCDC58 exhibits potential tumorigenic roles in a variety of malignancies. However, there is no systematic and comprehensive pan-cancer analysis to investigate the diagnosis, prognosis, immune infiltration, and other related functions of CCDC58. We used several online websites and databases, such as TCGA, GTEx, UALCAN, HPA, CancerSEA, BioGRID, GEPIA 2.0, TIMER 2.0, and TISIDB, to extract CCDC58 expression data and clinical data of patients in pan-cancer. Then, the relationship between CCDC58 expression and diagnosis, prognosis, genetic alterations, DNA methylation, genomic heterogeneity, and immune infiltration level were determined. In addition, the biological function of CCDC58 in liver hepatocellular carcinoma (LIHC) was investigated. Pan-cancer analysis results showed that CCDC58 was differentially expressed in most tumors and showed excellent performance in diagnosis and prediction of prognosis. The expression of CCDC58 was highly correlated with genetic alterations, DNA methylation, and genomic heterogeneity in some tumors. In addition, the correlation analysis of CCDC58 with the level of immune infiltration and immune checkpoint marker genes indicated that CCDC58 might affect the composition of the tumor immune microenvironment. Enrichment analysis showed that CCDC58-related genes were mainly linked to mitosis, chromosome, and cell cycle. Finally, biological function experiments demonstrated that CCDC58 plays an important role in tumor cell proliferation and migration. CCDC58 was first identified as a pan-cancer biomarker. It may be used as a potential therapeutic target to improve the prognosis of patients in the future.https://doi.org/10.1038/s41598-024-59154-9CCDC58Pan-cancerBiomarkerImmune infiltrationLIHC |
| spellingShingle | Kai Yang Yan Ma Weigang Chen Lu Liu Zelong Yang Chaokui He Nanbei Zheng Xinyu Liu Xin Cheng Junbo Song Yong Chen Hongyu Qiao Ruohan Zhang CCDC58 is a potential biomarker for diagnosis, prognosis, immunity, and genomic heterogeneity in pan-cancer Scientific Reports CCDC58 Pan-cancer Biomarker Immune infiltration LIHC |
| title | CCDC58 is a potential biomarker for diagnosis, prognosis, immunity, and genomic heterogeneity in pan-cancer |
| title_full | CCDC58 is a potential biomarker for diagnosis, prognosis, immunity, and genomic heterogeneity in pan-cancer |
| title_fullStr | CCDC58 is a potential biomarker for diagnosis, prognosis, immunity, and genomic heterogeneity in pan-cancer |
| title_full_unstemmed | CCDC58 is a potential biomarker for diagnosis, prognosis, immunity, and genomic heterogeneity in pan-cancer |
| title_short | CCDC58 is a potential biomarker for diagnosis, prognosis, immunity, and genomic heterogeneity in pan-cancer |
| title_sort | ccdc58 is a potential biomarker for diagnosis prognosis immunity and genomic heterogeneity in pan cancer |
| topic | CCDC58 Pan-cancer Biomarker Immune infiltration LIHC |
| url | https://doi.org/10.1038/s41598-024-59154-9 |
| work_keys_str_mv | AT kaiyang ccdc58isapotentialbiomarkerfordiagnosisprognosisimmunityandgenomicheterogeneityinpancancer AT yanma ccdc58isapotentialbiomarkerfordiagnosisprognosisimmunityandgenomicheterogeneityinpancancer AT weigangchen ccdc58isapotentialbiomarkerfordiagnosisprognosisimmunityandgenomicheterogeneityinpancancer AT luliu ccdc58isapotentialbiomarkerfordiagnosisprognosisimmunityandgenomicheterogeneityinpancancer AT zelongyang ccdc58isapotentialbiomarkerfordiagnosisprognosisimmunityandgenomicheterogeneityinpancancer AT chaokuihe ccdc58isapotentialbiomarkerfordiagnosisprognosisimmunityandgenomicheterogeneityinpancancer AT nanbeizheng ccdc58isapotentialbiomarkerfordiagnosisprognosisimmunityandgenomicheterogeneityinpancancer AT xinyuliu ccdc58isapotentialbiomarkerfordiagnosisprognosisimmunityandgenomicheterogeneityinpancancer AT xincheng ccdc58isapotentialbiomarkerfordiagnosisprognosisimmunityandgenomicheterogeneityinpancancer AT junbosong ccdc58isapotentialbiomarkerfordiagnosisprognosisimmunityandgenomicheterogeneityinpancancer AT yongchen ccdc58isapotentialbiomarkerfordiagnosisprognosisimmunityandgenomicheterogeneityinpancancer AT hongyuqiao ccdc58isapotentialbiomarkerfordiagnosisprognosisimmunityandgenomicheterogeneityinpancancer AT ruohanzhang ccdc58isapotentialbiomarkerfordiagnosisprognosisimmunityandgenomicheterogeneityinpancancer |