Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide in patients with pulmonary tuberculosis
Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide were studied in healthy controls and patients with active pulmonary tuberculosis. A case-control study of 29 controls and 30 cases attending at the Health Center, July, 2004 to December, 2005 was conducted....
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| Format: | Article |
| Language: | English |
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Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300011&lng=en&tlng=en |
| _version_ | 1818838048937345024 |
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| author | Mônica C. Façanha Argina M.B. Gondim Valéria G.F. Pinheiro Elizabeth C. Barroso Charles A. Peloquin Richard L. Guerrant Aldo A.M. Lima |
| author_facet | Mônica C. Façanha Argina M.B. Gondim Valéria G.F. Pinheiro Elizabeth C. Barroso Charles A. Peloquin Richard L. Guerrant Aldo A.M. Lima |
| author_sort | Mônica C. Façanha |
| collection | DOAJ |
| description | Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide were studied in healthy controls and patients with active pulmonary tuberculosis. A case-control study of 29 controls and 30 cases attending at the Health Center, July, 2004 to December, 2005 was conducted. The body mass index was significantly reduced in cases compared to controls (p < 0.001). The intestinal paracellular transport of lactulose was significantly (p = 0.019) reduced in cases compared to controls. The transcellular transport of mannitol and the lactulose:mannitol ratio were not significantly (p = 0.0698) reduced in cases compared to controls. Low serum concentrations of rifampin, isoniazid and pyrazinamide were observed in 81% (48/59), 92% (54/59) and 28% (12/59), respectively, in all individuals. The results demonstrated a marked decrease on intestinal paracellular transport in patients with active pulmonary tuberculosis and reduced serum concentrations of rifampin and isoniazid in both groups. |
| first_indexed | 2024-12-19T03:32:12Z |
| format | Article |
| id | doaj.art-d2473e76864f430881e790294d44f713 |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-19T03:32:12Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-d2473e76864f430881e790294d44f7132022-12-21T20:37:28ZengElsevierBrazilian Journal of Infectious Diseases1678-439113321021710.1590/S1413-86702009000300011S1413-86702009000300011Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide in patients with pulmonary tuberculosisMônica C. Façanha0Argina M.B. Gondim1Valéria G.F. Pinheiro2Elizabeth C. Barroso3Charles A. Peloquin4Richard L. Guerrant5Aldo A.M. Lima6Universidade Federal do CearáHealth Center Carlos RibeiroUniversidade Federal do CearáUniversidade Federal do CearáInfectious Disease Pharmacokinetics LaboratoryUniversidade Federal do CearáUniversidade Federal do CearáIntestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide were studied in healthy controls and patients with active pulmonary tuberculosis. A case-control study of 29 controls and 30 cases attending at the Health Center, July, 2004 to December, 2005 was conducted. The body mass index was significantly reduced in cases compared to controls (p < 0.001). The intestinal paracellular transport of lactulose was significantly (p = 0.019) reduced in cases compared to controls. The transcellular transport of mannitol and the lactulose:mannitol ratio were not significantly (p = 0.0698) reduced in cases compared to controls. Low serum concentrations of rifampin, isoniazid and pyrazinamide were observed in 81% (48/59), 92% (54/59) and 28% (12/59), respectively, in all individuals. The results demonstrated a marked decrease on intestinal paracellular transport in patients with active pulmonary tuberculosis and reduced serum concentrations of rifampin and isoniazid in both groups.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300011&lng=en&tlng=enTuberculosisbioavailability of antimycobacterial drugsintestinal barrier functionrifampinisoniazid and pyrazinamide |
| spellingShingle | Mônica C. Façanha Argina M.B. Gondim Valéria G.F. Pinheiro Elizabeth C. Barroso Charles A. Peloquin Richard L. Guerrant Aldo A.M. Lima Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide in patients with pulmonary tuberculosis Brazilian Journal of Infectious Diseases Tuberculosis bioavailability of antimycobacterial drugs intestinal barrier function rifampin isoniazid and pyrazinamide |
| title | Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide in patients with pulmonary tuberculosis |
| title_full | Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide in patients with pulmonary tuberculosis |
| title_fullStr | Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide in patients with pulmonary tuberculosis |
| title_full_unstemmed | Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide in patients with pulmonary tuberculosis |
| title_short | Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide in patients with pulmonary tuberculosis |
| title_sort | intestinal barrier function and serum concentrations of rifampin isoniazid and pyrazinamide in patients with pulmonary tuberculosis |
| topic | Tuberculosis bioavailability of antimycobacterial drugs intestinal barrier function rifampin isoniazid and pyrazinamide |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300011&lng=en&tlng=en |
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