CHROMATIN STRUCTURE AND DNA DAMAGE RESPONSE
Genomic integrity is constantly exposed to the products of metabolic activities and environmental processes that can induce DNA damage. A well-organized network of signaling cascade, designated as DNA damage response (DDR), encompasses systems of damage detection, cell-cycle check-point activation a...
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| Format: | Article |
| Language: | English |
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Avicenna Tajik State Medical University
2017-04-01
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| Series: | Паёми Сино |
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| Online Access: | https://doi.org/10.25005/2074-0581-2017-19-1-120-124 |
| _version_ | 1797796624240476160 |
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| author | M.A. NORMATOVA |
| author_facet | M.A. NORMATOVA |
| author_sort | M.A. NORMATOVA |
| collection | DOAJ |
| description | Genomic integrity is constantly exposed to the products of metabolic activities and environmental processes that can induce DNA damage. A well-organized network of signaling cascade, designated as DNA damage response (DDR), encompasses systems of damage detection, cell-cycle check-point activation and repair mechanisms. The DNA damage pathways involve not only naked DNA strands but also higherorder chromatin components, such as histone variants and heterochromatin proteins. Any impediment of this regulation process may cause extensive damage and trigger the growth of tumours. The alterations in chromatin architecture occur during transcription and replication and are required to provide the accessibility of proteins to DNA strands. There is increasing evidence that DNA repair is also accompanied by the chromatin remodeling, particularly in the case of efficient detection and repair of DSBs where chromatin structure and nucleosome organization represent a significant barrier. |
| first_indexed | 2024-03-13T03:35:50Z |
| format | Article |
| id | doaj.art-d247f70932464c71a0363ab819da0aca |
| institution | Directory Open Access Journal |
| issn | 2074-0581 2959-6327 |
| language | English |
| last_indexed | 2024-03-13T03:35:50Z |
| publishDate | 2017-04-01 |
| publisher | Avicenna Tajik State Medical University |
| record_format | Article |
| series | Паёми Сино |
| spelling | doaj.art-d247f70932464c71a0363ab819da0aca2023-06-23T20:06:38ZengAvicenna Tajik State Medical UniversityПаёми Сино2074-05812959-63272017-04-0119112012410.25005/2074-0581-2017-19-1-120-124CHROMATIN STRUCTURE AND DNA DAMAGE RESPONSEM.A. NORMATOVA0Avicenna Tajik State Medical University, Dushanbe, TajikistanGenomic integrity is constantly exposed to the products of metabolic activities and environmental processes that can induce DNA damage. A well-organized network of signaling cascade, designated as DNA damage response (DDR), encompasses systems of damage detection, cell-cycle check-point activation and repair mechanisms. The DNA damage pathways involve not only naked DNA strands but also higherorder chromatin components, such as histone variants and heterochromatin proteins. Any impediment of this regulation process may cause extensive damage and trigger the growth of tumours. The alterations in chromatin architecture occur during transcription and replication and are required to provide the accessibility of proteins to DNA strands. There is increasing evidence that DNA repair is also accompanied by the chromatin remodeling, particularly in the case of efficient detection and repair of DSBs where chromatin structure and nucleosome organization represent a significant barrier.https://doi.org/10.25005/2074-0581-2017-19-1-120-124dna damageatmatrchromatindsbsddr. |
| spellingShingle | M.A. NORMATOVA CHROMATIN STRUCTURE AND DNA DAMAGE RESPONSE Паёми Сино dna damage atm atr chromatin dsbs ddr. |
| title | CHROMATIN STRUCTURE AND DNA DAMAGE RESPONSE |
| title_full | CHROMATIN STRUCTURE AND DNA DAMAGE RESPONSE |
| title_fullStr | CHROMATIN STRUCTURE AND DNA DAMAGE RESPONSE |
| title_full_unstemmed | CHROMATIN STRUCTURE AND DNA DAMAGE RESPONSE |
| title_short | CHROMATIN STRUCTURE AND DNA DAMAGE RESPONSE |
| title_sort | chromatin structure and dna damage response |
| topic | dna damage atm atr chromatin dsbs ddr. |
| url | https://doi.org/10.25005/2074-0581-2017-19-1-120-124 |
| work_keys_str_mv | AT manormatova chromatinstructureanddnadamageresponse |