Microstate Changes Associated With Alzheimer’s Disease in Persons With Down Syndrome
Down syndrome (DS) is associated with development of dementia due to Alzheimer’s disease (AD). However, due to considerable heterogeneity in intellectual function among persons with DS, it is difficult to assess whether a person with DS has developed dementia due to AD (DS-AD). EEG spectral power ha...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.01251/full |
| _version_ | 1811285394631688192 |
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| author | Christian Sandøe Musaeus Lise Cronberg Salem Troels Wesenberg Kjaer Troels Wesenberg Kjaer Gunhild Waldemar Gunhild Waldemar |
| author_facet | Christian Sandøe Musaeus Lise Cronberg Salem Troels Wesenberg Kjaer Troels Wesenberg Kjaer Gunhild Waldemar Gunhild Waldemar |
| author_sort | Christian Sandøe Musaeus |
| collection | DOAJ |
| description | Down syndrome (DS) is associated with development of dementia due to Alzheimer’s disease (AD). However, due to considerable heterogeneity in intellectual function among persons with DS, it is difficult to assess whether a person with DS has developed dementia due to AD (DS-AD). EEG spectral power has previously shown very promising results with increased slowing in DS-AD compared to DS. However, another technique called microstates may be used to assess whole-brain dynamics and has to our knowledge not previously been investigated in either DS or DS-AD. The aim of the current study was to assess whether microstates could be used to differentiate between adults with DS, and DS-AD. We included EEGs from 10 persons with DS and 15 persons with DS-AD in the analysis. For the microstate analyses, we calculated four global maps, which were then back-fitted to all the EEGs. Lastly, we extracted the duration, occurrence, and coverage for each of the microstates. Here, we found the four archetypical maps as has previously been reported in the literature. We did not find any significant difference between DS and DS-AD but the largest difference in microstate duration between DS and DS-AD was found in microstate A and D. These findings are in line with structural MR studies showing that both the frontal and temporal lobes are affected in persons with DS-AD. Microstates may potentially serve as a diagnostic marker, but larger studies are needed to confirm these findings. |
| first_indexed | 2024-04-13T02:43:27Z |
| format | Article |
| id | doaj.art-d24a3e9cbb4342119af4030c3e3f0719 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-13T02:43:27Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-d24a3e9cbb4342119af4030c3e3f07192022-12-22T03:06:07ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-11-011310.3389/fnins.2019.01251481904Microstate Changes Associated With Alzheimer’s Disease in Persons With Down SyndromeChristian Sandøe Musaeus0Lise Cronberg Salem1Troels Wesenberg Kjaer2Troels Wesenberg Kjaer3Gunhild Waldemar4Gunhild Waldemar5Danish Dementia Research Centre, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, DenmarkDanish Dementia Research Centre, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, DenmarkDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, DenmarkNeurophysiology Center, Zealand University Hospital, Roskilde, DenmarkDanish Dementia Research Centre, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, DenmarkDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, DenmarkDown syndrome (DS) is associated with development of dementia due to Alzheimer’s disease (AD). However, due to considerable heterogeneity in intellectual function among persons with DS, it is difficult to assess whether a person with DS has developed dementia due to AD (DS-AD). EEG spectral power has previously shown very promising results with increased slowing in DS-AD compared to DS. However, another technique called microstates may be used to assess whole-brain dynamics and has to our knowledge not previously been investigated in either DS or DS-AD. The aim of the current study was to assess whether microstates could be used to differentiate between adults with DS, and DS-AD. We included EEGs from 10 persons with DS and 15 persons with DS-AD in the analysis. For the microstate analyses, we calculated four global maps, which were then back-fitted to all the EEGs. Lastly, we extracted the duration, occurrence, and coverage for each of the microstates. Here, we found the four archetypical maps as has previously been reported in the literature. We did not find any significant difference between DS and DS-AD but the largest difference in microstate duration between DS and DS-AD was found in microstate A and D. These findings are in line with structural MR studies showing that both the frontal and temporal lobes are affected in persons with DS-AD. Microstates may potentially serve as a diagnostic marker, but larger studies are needed to confirm these findings.https://www.frontiersin.org/article/10.3389/fnins.2019.01251/fullDown syndromeEEGAlzheimer’s diseasemicrostatesdiagnostic |
| spellingShingle | Christian Sandøe Musaeus Lise Cronberg Salem Troels Wesenberg Kjaer Troels Wesenberg Kjaer Gunhild Waldemar Gunhild Waldemar Microstate Changes Associated With Alzheimer’s Disease in Persons With Down Syndrome Frontiers in Neuroscience Down syndrome EEG Alzheimer’s disease microstates diagnostic |
| title | Microstate Changes Associated With Alzheimer’s Disease in Persons With Down Syndrome |
| title_full | Microstate Changes Associated With Alzheimer’s Disease in Persons With Down Syndrome |
| title_fullStr | Microstate Changes Associated With Alzheimer’s Disease in Persons With Down Syndrome |
| title_full_unstemmed | Microstate Changes Associated With Alzheimer’s Disease in Persons With Down Syndrome |
| title_short | Microstate Changes Associated With Alzheimer’s Disease in Persons With Down Syndrome |
| title_sort | microstate changes associated with alzheimer s disease in persons with down syndrome |
| topic | Down syndrome EEG Alzheimer’s disease microstates diagnostic |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.01251/full |
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