Additional diagnostic capabilities in the practice of a PAP-test using liquid-based cytology
The role of oncogenic strains of human papillomavirus in the development of cervical cancer is currently not in doubt. In cervical cancer screening, a co-testing strategy is used, in which cytology and HPV testing are performed. When performing a cytological examination by liquid-based cytology, it...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Eco-vector
2021-03-01
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| Series: | Клиническая практика |
| Subjects: | |
| Online Access: | https://journals.eco-vector.com/clinpractice/article/viewFile/64982/pdf |
| _version_ | 1797717497602899968 |
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| author | Artem K. Aksamentov Nadezhda V. Melnikova Nadezhda A. Kolyshkina Olga N. Kucherova Vladimir P. Baklaushev |
| author_facet | Artem K. Aksamentov Nadezhda V. Melnikova Nadezhda A. Kolyshkina Olga N. Kucherova Vladimir P. Baklaushev |
| author_sort | Artem K. Aksamentov |
| collection | DOAJ |
| description | The role of oncogenic strains of human papillomavirus in the development of cervical cancer is currently not in doubt. In cervical cancer screening, a co-testing strategy is used, in which cytology and HPV testing are performed. When performing a cytological examination by liquid-based cytology, it is possible to conduct additional diagnostic studies that can be used to more effectively sort patients in order to optimize the volume of diagnostic and therapeutic measures. The article highlights the possibilities of diagnostic tests based on the assessment of microRNA and mRNA expression, as well as tests based on the analysis of DNA methylation from the cytological material. The introduction of new molecular genetic predictors of the cervical cancer development into clinical practice can increase the effectiveness of currently used screening programs. |
| first_indexed | 2024-03-12T08:38:11Z |
| format | Article |
| id | doaj.art-d24bf8e2667b41de82f65687df9e9e6e |
| institution | Directory Open Access Journal |
| issn | 2220-3095 2618-8627 |
| language | English |
| last_indexed | 2024-03-12T08:38:11Z |
| publishDate | 2021-03-01 |
| publisher | Eco-vector |
| record_format | Article |
| series | Клиническая практика |
| spelling | doaj.art-d24bf8e2667b41de82f65687df9e9e6e2023-09-02T17:09:08ZengEco-vectorКлиническая практика2220-30952618-86272021-03-01121828910.17816/clinpract6498264471Additional diagnostic capabilities in the practice of a PAP-test using liquid-based cytologyArtem K. Aksamentov0https://orcid.org/0000-0002-7980-2537Nadezhda V. Melnikova1https://orcid.org/0000-0003-1193-352XNadezhda A. Kolyshkina2https://orcid.org/0000-0003-4486-5412Olga N. Kucherova3https://orcid.org/0000-0003-3773-9629Vladimir P. Baklaushev4https://orcid.org/0000-0003-1039-4245Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of RussiaFederal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of RussiaFederal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of RussiaCity Clinical Hospital named after V.V. Vinogradov of the Department of Health of the city of MoscowFederal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of RussiaThe role of oncogenic strains of human papillomavirus in the development of cervical cancer is currently not in doubt. In cervical cancer screening, a co-testing strategy is used, in which cytology and HPV testing are performed. When performing a cytological examination by liquid-based cytology, it is possible to conduct additional diagnostic studies that can be used to more effectively sort patients in order to optimize the volume of diagnostic and therapeutic measures. The article highlights the possibilities of diagnostic tests based on the assessment of microRNA and mRNA expression, as well as tests based on the analysis of DNA methylation from the cytological material. The introduction of new molecular genetic predictors of the cervical cancer development into clinical practice can increase the effectiveness of currently used screening programs.https://journals.eco-vector.com/clinpractice/article/viewFile/64982/pdfpap-testscreeningcervical cancermirnamrnaliquid-based cytologydna methylation |
| spellingShingle | Artem K. Aksamentov Nadezhda V. Melnikova Nadezhda A. Kolyshkina Olga N. Kucherova Vladimir P. Baklaushev Additional diagnostic capabilities in the practice of a PAP-test using liquid-based cytology Клиническая практика pap-test screening cervical cancer mirna mrna liquid-based cytology dna methylation |
| title | Additional diagnostic capabilities in the practice of a PAP-test using liquid-based cytology |
| title_full | Additional diagnostic capabilities in the practice of a PAP-test using liquid-based cytology |
| title_fullStr | Additional diagnostic capabilities in the practice of a PAP-test using liquid-based cytology |
| title_full_unstemmed | Additional diagnostic capabilities in the practice of a PAP-test using liquid-based cytology |
| title_short | Additional diagnostic capabilities in the practice of a PAP-test using liquid-based cytology |
| title_sort | additional diagnostic capabilities in the practice of a pap test using liquid based cytology |
| topic | pap-test screening cervical cancer mirna mrna liquid-based cytology dna methylation |
| url | https://journals.eco-vector.com/clinpractice/article/viewFile/64982/pdf |
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