Hepatitis B virus (HBV) serological patterns among the HBsAg negative hospital attendees screened for immunization
Abstract The Hepatitis B virus (HBV) is a highly infectious virus and is endemic in Uganda. It is one of the major etiological agents for liver diseases including liver cancer. In this work, we evaluated the prevalence of the HBV serological markers and the associated socio-demographic factors among...
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| Format: | Article |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-11535-8 |
| _version_ | 1818251255212933120 |
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| author | Hussein Mukasa Kafeero Dorothy Ndagire Ponsiano Ocama Charles Drago Kato Eddie Wampande Abdul Walusansa Henry Kajumbula David Kateete Hakim Sendagire |
| author_facet | Hussein Mukasa Kafeero Dorothy Ndagire Ponsiano Ocama Charles Drago Kato Eddie Wampande Abdul Walusansa Henry Kajumbula David Kateete Hakim Sendagire |
| author_sort | Hussein Mukasa Kafeero |
| collection | DOAJ |
| description | Abstract The Hepatitis B virus (HBV) is a highly infectious virus and is endemic in Uganda. It is one of the major etiological agents for liver diseases including liver cancer. In this work, we evaluated the prevalence of the HBV serological markers and the associated socio-demographic factors among hepatitis B surface antigen (HBsAg) seronegative persons screened during routine immunization against the virus in eastern Uganda. Data on the socio-demographic characteristics were collected using a structured questionnaire, while that on the serological markers were obtained from serum samples and evaluated by using the 5-panel HBV One Step Hepatitis B Virus Combo Test Device (FastepR, HBV-P43M). The following markers were evaluated by the panel: HBsAg, HBsAb, HBcAb, and HBeAb. Data were analyzed using SPSS (version 26), and multinomial logistic regression was used to elicit the adjusted odds ratio. All the analysis were performed at a 95% confidence limit, and a P value ≤ 0.05 was considered significant. The 424 participants included in this study were mainly female (62.3%), married (55.4%) and aged 30 years and above (54.2%). The seropositivity of the HBsAb, HBeAb, HBcAb marker prevalence rates was 48(11.3%), 73(17.2%) and 45(10.6%) respectively. The majority of the participants (327, 77.1%) did not present with any marker. Married paricipants were significantly associated with reduced HBsAb seropositvity rate, whereas young people aged 18–29 years were associated the with increased odds of HBsAb seropositivity (p < 0.05). Male participants were significantly associated with the HBeAb and HBcAb seropositivity (p < 0.05). Similarly, contact with an HBV infected person was significantly associated with HBeAb and HBcAb seropositivity (p < 0.05). Further still, blood transfusion was significantly associated with the increased risk of HBcAb seropositivity (P < 0.05). This study has revealed a prevalence of HBV serological markers among the HBsAg seronegative persons in this community and an increased risk of transmission of the virus in the community. Our findings have key consequences pertaining the interventions that are pertinent in the control and prevention of the spread of the virus among apparently health persons. |
| first_indexed | 2024-12-12T16:05:22Z |
| format | Article |
| id | doaj.art-d24dbadfd8a64037b0549e25edb95ba3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-12T16:05:22Z |
| publishDate | 2022-05-01 |
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| spelling | doaj.art-d24dbadfd8a64037b0549e25edb95ba32022-12-22T00:19:20ZengNature PortfolioScientific Reports2045-23222022-05-0112111010.1038/s41598-022-11535-8Hepatitis B virus (HBV) serological patterns among the HBsAg negative hospital attendees screened for immunizationHussein Mukasa Kafeero0Dorothy Ndagire1Ponsiano Ocama2Charles Drago Kato3Eddie Wampande4Abdul Walusansa5Henry Kajumbula6David Kateete7Hakim Sendagire8Department of Medical Microbiology, College of Health Sciences, Makerere UniversityDepartment of Plant Sciences, Microbiology and Biotechnology, College of Natural Sciences, Makerere UniversityDepartment of Medicine, College of Health Sciences, Makerere UniversityDepartment of Molecular Biology and Immunology, College of Health Sciences, Makerere UniversityDepartment of Biomolecular Resources and Biolab Sciences, College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere UniversityDepartment of Medical Microbiology, Habib Medical School, Faculty of Health Sciences, Islamic University in UgandaDepartment of Medical Microbiology, College of Health Sciences, Makerere UniversityDepartment of Biomolecular Resources and Biolab Sciences, College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere UniversityDepartment of Medical Microbiology, College of Health Sciences, Makerere UniversityAbstract The Hepatitis B virus (HBV) is a highly infectious virus and is endemic in Uganda. It is one of the major etiological agents for liver diseases including liver cancer. In this work, we evaluated the prevalence of the HBV serological markers and the associated socio-demographic factors among hepatitis B surface antigen (HBsAg) seronegative persons screened during routine immunization against the virus in eastern Uganda. Data on the socio-demographic characteristics were collected using a structured questionnaire, while that on the serological markers were obtained from serum samples and evaluated by using the 5-panel HBV One Step Hepatitis B Virus Combo Test Device (FastepR, HBV-P43M). The following markers were evaluated by the panel: HBsAg, HBsAb, HBcAb, and HBeAb. Data were analyzed using SPSS (version 26), and multinomial logistic regression was used to elicit the adjusted odds ratio. All the analysis were performed at a 95% confidence limit, and a P value ≤ 0.05 was considered significant. The 424 participants included in this study were mainly female (62.3%), married (55.4%) and aged 30 years and above (54.2%). The seropositivity of the HBsAb, HBeAb, HBcAb marker prevalence rates was 48(11.3%), 73(17.2%) and 45(10.6%) respectively. The majority of the participants (327, 77.1%) did not present with any marker. Married paricipants were significantly associated with reduced HBsAb seropositvity rate, whereas young people aged 18–29 years were associated the with increased odds of HBsAb seropositivity (p < 0.05). Male participants were significantly associated with the HBeAb and HBcAb seropositivity (p < 0.05). Similarly, contact with an HBV infected person was significantly associated with HBeAb and HBcAb seropositivity (p < 0.05). Further still, blood transfusion was significantly associated with the increased risk of HBcAb seropositivity (P < 0.05). This study has revealed a prevalence of HBV serological markers among the HBsAg seronegative persons in this community and an increased risk of transmission of the virus in the community. Our findings have key consequences pertaining the interventions that are pertinent in the control and prevention of the spread of the virus among apparently health persons.https://doi.org/10.1038/s41598-022-11535-8 |
| spellingShingle | Hussein Mukasa Kafeero Dorothy Ndagire Ponsiano Ocama Charles Drago Kato Eddie Wampande Abdul Walusansa Henry Kajumbula David Kateete Hakim Sendagire Hepatitis B virus (HBV) serological patterns among the HBsAg negative hospital attendees screened for immunization Scientific Reports |
| title | Hepatitis B virus (HBV) serological patterns among the HBsAg negative hospital attendees screened for immunization |
| title_full | Hepatitis B virus (HBV) serological patterns among the HBsAg negative hospital attendees screened for immunization |
| title_fullStr | Hepatitis B virus (HBV) serological patterns among the HBsAg negative hospital attendees screened for immunization |
| title_full_unstemmed | Hepatitis B virus (HBV) serological patterns among the HBsAg negative hospital attendees screened for immunization |
| title_short | Hepatitis B virus (HBV) serological patterns among the HBsAg negative hospital attendees screened for immunization |
| title_sort | hepatitis b virus hbv serological patterns among the hbsag negative hospital attendees screened for immunization |
| url | https://doi.org/10.1038/s41598-022-11535-8 |
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