Modulation of G-protein activation, calcium currents and opioid receptor phosphorylation by the pH-dependent antinociceptive agonist NFEPP

Modulation of G-protein activation, calcium currents and opioid receptor phosphorylation by the pH-dependent antinociceptive agonist NFEPP

N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide is a newly-designed pain killer selectively activating G-protein-coupled mu-opioid receptors (MOR) in acidic injured tissues, and therefore devoid of central side effects which are typically elicited at normal pH values in healthy tissues...

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Bibliographic Details
Main Authors: Melih Özgür Celik, Viola Seitz, Fatih Yergöz, Sandeep Dembla, Nina Kathleen Blum, Stefan Schulz, Christoph Stein
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
NFEPP
mu opioid receptor (MOR)
VDCC
fentanyl
pain
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1171855/full

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