The Regulatory Roles of Cerebellar Glycosphingolipid Microdomains/Lipid Rafts
Lipid rafts are dynamic assemblies of glycosphingolipids, sphingomyelin, cholesterol, and specific proteins which are stabilized into platforms involved in the regulation of vital cellular processes. Cerebellar lipid rafts are cell surface ganglioside microdomains for the attachment of GPI-anchored...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/6/5566 |
| _version_ | 1797611270466174976 |
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| author | Keisuke Komatsuya Norihito Kikuchi Tetsuya Hirabayashi Kohji Kasahara |
| author_facet | Keisuke Komatsuya Norihito Kikuchi Tetsuya Hirabayashi Kohji Kasahara |
| author_sort | Keisuke Komatsuya |
| collection | DOAJ |
| description | Lipid rafts are dynamic assemblies of glycosphingolipids, sphingomyelin, cholesterol, and specific proteins which are stabilized into platforms involved in the regulation of vital cellular processes. Cerebellar lipid rafts are cell surface ganglioside microdomains for the attachment of GPI-anchored neural adhesion molecules and downstream signaling molecules such as Src-family kinases and heterotrimeric G proteins. In this review, we summarize our recent findings on signaling in ganglioside GD3 rafts of cerebellar granule cells and several findings by other groups on the roles of lipid rafts in the cerebellum. TAG-1, of the contactin group of immunoglobulin superfamily cell adhesion molecules, is a phosphacan receptor. Phosphacan regulates the radial migration signaling of cerebellar granule cells, via Src-family kinase Lyn, by binding to TAG-1 on ganglioside GD3 rafts. Chemokine SDF-1α, which induces the tangential migration of cerebellar granule cells, causes heterotrimeric G protein Goα translocation to GD3 rafts. Furthermore, the functional roles of cerebellar raft-binding proteins including cell adhesion molecule L1, heterotrimeric G protein Gsα, and L-type voltage-dependent calcium channels are discussed. |
| first_indexed | 2024-03-11T06:26:28Z |
| format | Article |
| id | doaj.art-d24fab0f8fda494589d552766439c267 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T06:26:28Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d24fab0f8fda494589d552766439c2672023-11-17T11:35:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01246556610.3390/ijms24065566The Regulatory Roles of Cerebellar Glycosphingolipid Microdomains/Lipid RaftsKeisuke Komatsuya0Norihito Kikuchi1Tetsuya Hirabayashi2Kohji Kasahara3Laboratory of Biomembrane, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, JapanLaboratory of Biomembrane, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, JapanLaboratory of Biomembrane, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, JapanLaboratory of Biomembrane, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, JapanLipid rafts are dynamic assemblies of glycosphingolipids, sphingomyelin, cholesterol, and specific proteins which are stabilized into platforms involved in the regulation of vital cellular processes. Cerebellar lipid rafts are cell surface ganglioside microdomains for the attachment of GPI-anchored neural adhesion molecules and downstream signaling molecules such as Src-family kinases and heterotrimeric G proteins. In this review, we summarize our recent findings on signaling in ganglioside GD3 rafts of cerebellar granule cells and several findings by other groups on the roles of lipid rafts in the cerebellum. TAG-1, of the contactin group of immunoglobulin superfamily cell adhesion molecules, is a phosphacan receptor. Phosphacan regulates the radial migration signaling of cerebellar granule cells, via Src-family kinase Lyn, by binding to TAG-1 on ganglioside GD3 rafts. Chemokine SDF-1α, which induces the tangential migration of cerebellar granule cells, causes heterotrimeric G protein Goα translocation to GD3 rafts. Furthermore, the functional roles of cerebellar raft-binding proteins including cell adhesion molecule L1, heterotrimeric G protein Gsα, and L-type voltage-dependent calcium channels are discussed.https://www.mdpi.com/1422-0067/24/6/5566lipid raftsgangliosidesGPI-anchored proteinsSrc-family kinasesheterotrimeric G proteins |
| spellingShingle | Keisuke Komatsuya Norihito Kikuchi Tetsuya Hirabayashi Kohji Kasahara The Regulatory Roles of Cerebellar Glycosphingolipid Microdomains/Lipid Rafts International Journal of Molecular Sciences lipid rafts gangliosides GPI-anchored proteins Src-family kinases heterotrimeric G proteins |
| title | The Regulatory Roles of Cerebellar Glycosphingolipid Microdomains/Lipid Rafts |
| title_full | The Regulatory Roles of Cerebellar Glycosphingolipid Microdomains/Lipid Rafts |
| title_fullStr | The Regulatory Roles of Cerebellar Glycosphingolipid Microdomains/Lipid Rafts |
| title_full_unstemmed | The Regulatory Roles of Cerebellar Glycosphingolipid Microdomains/Lipid Rafts |
| title_short | The Regulatory Roles of Cerebellar Glycosphingolipid Microdomains/Lipid Rafts |
| title_sort | regulatory roles of cerebellar glycosphingolipid microdomains lipid rafts |
| topic | lipid rafts gangliosides GPI-anchored proteins Src-family kinases heterotrimeric G proteins |
| url | https://www.mdpi.com/1422-0067/24/6/5566 |
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