Oligometastasis of Gastric Cancer: A Review
The concept of oligometastasis is not yet fully established in the field of gastric cancer. However, metastatic lesions that are localized, technically resectable at diagnosis, present a certain response to preoperative chemotherapy, and present favorable survival outcomes with local treatments, som...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/16/3/673 |
| _version_ | 1797318966314532864 |
|---|---|
| author | Itaru Yasufuku Hiroshi Tsuchiya Seito Fujibayashi Naoki Okumura Yuki Sengoku Masahiro Fukada Ryuichi Asai Yuta Sato Jesse Yu Tajima Shigeru Kiyama Takazumi Kato Yoshihiro Tanaka Katsutoshi Murase Nobuhisa Matsuhashi |
| author_facet | Itaru Yasufuku Hiroshi Tsuchiya Seito Fujibayashi Naoki Okumura Yuki Sengoku Masahiro Fukada Ryuichi Asai Yuta Sato Jesse Yu Tajima Shigeru Kiyama Takazumi Kato Yoshihiro Tanaka Katsutoshi Murase Nobuhisa Matsuhashi |
| author_sort | Itaru Yasufuku |
| collection | DOAJ |
| description | The concept of oligometastasis is not yet fully established in the field of gastric cancer. However, metastatic lesions that are localized, technically resectable at diagnosis, present a certain response to preoperative chemotherapy, and present favorable survival outcomes with local treatments, sometimes in combination with chemotherapy, are recognized as oligometastasis in the field of gastric cancer. Oligometastasis is noted in European Society for Medical Oncology guidelines and Japanese gastric cancer treatment guidelines, and local treatment is mentioned as one of the pivotal treatment options for oligometastasis. Solitary liver metastasis or a small number of liver metastases; retroperitoneal lymph node metastasis, especially localized para-aortic lymph node metastasis; localized peritoneal dissemination; and Krukenberg tumor are representative types of oligometastasis in gastric cancer. The AIO-FLOT3 trial prospectively evaluated the efficacy of multimodal treatments for gastric cancer with oligometastasis, including surgical resection of primary and metastatic lesions combined with chemotherapy, confirming favorable survival outcomes. Two phase 3 studies are ongoing to investigate the efficacy of surgical resection combined with perioperative chemotherapy compared with palliative chemotherapy. Thus far, the evidence suggests that multimodal treatment for oligometastasis of gastric cancer is promising. |
| first_indexed | 2024-03-08T04:00:01Z |
| format | Article |
| id | doaj.art-d251bbcddcbd40cd8edad66001db8967 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-08T04:00:01Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-d251bbcddcbd40cd8edad66001db89672024-02-09T15:09:32ZengMDPI AGCancers2072-66942024-02-0116367310.3390/cancers16030673Oligometastasis of Gastric Cancer: A ReviewItaru Yasufuku0Hiroshi Tsuchiya1Seito Fujibayashi2Naoki Okumura3Yuki Sengoku4Masahiro Fukada5Ryuichi Asai6Yuta Sato7Jesse Yu Tajima8Shigeru Kiyama9Takazumi Kato10Yoshihiro Tanaka11Katsutoshi Murase12Nobuhisa Matsuhashi13Department of Clinical Anatomy Development Studies, Gifu University Graduate School of Medicine, Yanagito 1-1, Gifu City 501-1194, JapanDepartment of Gastroenterological and Pediatric Surgery, Gifu University Graduate School of Medicine, Yanagito 1-1, Gifu City 501-1194, JapanDepartment of Gastroenterological and Pediatric Surgery, Gifu University Graduate School of Medicine, Yanagito 1-1, Gifu City 501-1194, JapanDepartment of Gastroenterological and Pediatric Surgery, Gifu University Graduate School of Medicine, Yanagito 1-1, Gifu City 501-1194, JapanDepartment of Gastroenterological and Pediatric Surgery, Gifu University Graduate School of Medicine, Yanagito 1-1, Gifu City 501-1194, JapanDepartment of Gastroenterological and Pediatric Surgery, Gifu University Graduate School of Medicine, Yanagito 1-1, Gifu City 501-1194, JapanDepartment of Gastroenterological and Pediatric Surgery, Gifu University Graduate School of Medicine, Yanagito 1-1, Gifu City 501-1194, JapanDepartment of Gastroenterological and Pediatric Surgery, Gifu University Graduate School of Medicine, Yanagito 1-1, Gifu City 501-1194, JapanDepartment of Gastroenterological and Pediatric Surgery, Gifu University Graduate School of Medicine, Yanagito 1-1, Gifu City 501-1194, JapanDepartment of Gastroenterological and Pediatric Surgery, Gifu University Graduate School of Medicine, Yanagito 1-1, Gifu City 501-1194, JapanDepartment of Gastroenterological and Pediatric Surgery, Gifu University Graduate School of Medicine, Yanagito 1-1, Gifu City 501-1194, JapanDepartment of Gastroenterological and Pediatric Surgery, Gifu University Graduate School of Medicine, Yanagito 1-1, Gifu City 501-1194, JapanDepartment of Gastroenterological and Pediatric Surgery, Gifu University Graduate School of Medicine, Yanagito 1-1, Gifu City 501-1194, JapanDepartment of Gastroenterological and Pediatric Surgery, Gifu University Graduate School of Medicine, Yanagito 1-1, Gifu City 501-1194, JapanThe concept of oligometastasis is not yet fully established in the field of gastric cancer. However, metastatic lesions that are localized, technically resectable at diagnosis, present a certain response to preoperative chemotherapy, and present favorable survival outcomes with local treatments, sometimes in combination with chemotherapy, are recognized as oligometastasis in the field of gastric cancer. Oligometastasis is noted in European Society for Medical Oncology guidelines and Japanese gastric cancer treatment guidelines, and local treatment is mentioned as one of the pivotal treatment options for oligometastasis. Solitary liver metastasis or a small number of liver metastases; retroperitoneal lymph node metastasis, especially localized para-aortic lymph node metastasis; localized peritoneal dissemination; and Krukenberg tumor are representative types of oligometastasis in gastric cancer. The AIO-FLOT3 trial prospectively evaluated the efficacy of multimodal treatments for gastric cancer with oligometastasis, including surgical resection of primary and metastatic lesions combined with chemotherapy, confirming favorable survival outcomes. Two phase 3 studies are ongoing to investigate the efficacy of surgical resection combined with perioperative chemotherapy compared with palliative chemotherapy. Thus far, the evidence suggests that multimodal treatment for oligometastasis of gastric cancer is promising.https://www.mdpi.com/2072-6694/16/3/673oligo-recurrenceoligometastasissystemic therapylocal therapysurgerymultimodal therapy |
| spellingShingle | Itaru Yasufuku Hiroshi Tsuchiya Seito Fujibayashi Naoki Okumura Yuki Sengoku Masahiro Fukada Ryuichi Asai Yuta Sato Jesse Yu Tajima Shigeru Kiyama Takazumi Kato Yoshihiro Tanaka Katsutoshi Murase Nobuhisa Matsuhashi Oligometastasis of Gastric Cancer: A Review Cancers oligo-recurrence oligometastasis systemic therapy local therapy surgery multimodal therapy |
| title | Oligometastasis of Gastric Cancer: A Review |
| title_full | Oligometastasis of Gastric Cancer: A Review |
| title_fullStr | Oligometastasis of Gastric Cancer: A Review |
| title_full_unstemmed | Oligometastasis of Gastric Cancer: A Review |
| title_short | Oligometastasis of Gastric Cancer: A Review |
| title_sort | oligometastasis of gastric cancer a review |
| topic | oligo-recurrence oligometastasis systemic therapy local therapy surgery multimodal therapy |
| url | https://www.mdpi.com/2072-6694/16/3/673 |
| work_keys_str_mv | AT itaruyasufuku oligometastasisofgastriccancerareview AT hiroshitsuchiya oligometastasisofgastriccancerareview AT seitofujibayashi oligometastasisofgastriccancerareview AT naokiokumura oligometastasisofgastriccancerareview AT yukisengoku oligometastasisofgastriccancerareview AT masahirofukada oligometastasisofgastriccancerareview AT ryuichiasai oligometastasisofgastriccancerareview AT yutasato oligometastasisofgastriccancerareview AT jesseyutajima oligometastasisofgastriccancerareview AT shigerukiyama oligometastasisofgastriccancerareview AT takazumikato oligometastasisofgastriccancerareview AT yoshihirotanaka oligometastasisofgastriccancerareview AT katsutoshimurase oligometastasisofgastriccancerareview AT nobuhisamatsuhashi oligometastasisofgastriccancerareview |